4,4'-二甲基八氟联苯 | 26475-18-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4'-二甲基八氟联苯
• 中文别名: 4,4-二甲基八氟联苯
• 英文名称: 2,2',3,3',5,5',6,6'-octafluoro-4,4'-dimethyl-1,1'-biphenyl
• 英文别名: 4,4'-dimethyloctafluorobiphenyl；4,4'-Dimethyloctafluorbiphenyl；1,2,4,5-tetrafluoro-3-methyl-6-(2,3,5,6-tetrafluoro-4-methylphenyl)benzene
• CAS: 26475-18-3
• 化学式: C₁₄H₆F₈
• mdl: MFCD00000314
• 分子量: 326.189
• InChiKey: IMAVLXWSVGAOCU-UHFFFAOYSA-N

物化性质

• 熔点：
  144-148 °C
• 沸点：
  302.05°C (rough estimate)
• 密度：
  1.1737 (rough estimate)
• 稳定性/保质期：
  避免接触强氧化剂。

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  8

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2903999090
• 储存条件：
  将物品存放在紧密封装的容器中，并储存在阴凉、干燥的地方。

SDS

Name:	4 4 -Dimethyloctafluorobiphenyl 97% Material Safety Data Sheet
Synonym:	D-Pyroglutamic acid ethyl este
CAS:	26475-18-3

Section 1 - Chemical Product MSDS Name:4 4 -Dimethyloctafluorobiphenyl 97% Material Safety Data Sheet
Synonym:D-Pyroglutamic acid ethyl este

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
26475-18-3	4,4'-Dimethyloctafluorobiphenyl	97	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation.
Chronic:
No information found.

---

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 26475-18-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 149 - 151 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C14H6F8
Molecular Weight: 326.19

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride gas.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 26475-18-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4,4'-Dimethyloctafluorobiphenyl - Not listed by ACGIH, IARC, or NTP.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 26475-18-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 26475-18-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 26475-18-3 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4,4'-二甲基八氟联苯 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 96.0h， 生成 4,4'-bis(diethoxyphosphonomethyl)octafluorobiphenyl
  参考文献：
  名称：

  分子结构对亚苯基亚乙烯基共轭低聚物的抗菌功能的影响†

  摘要：

  已知具有亚苯基亚乙烯基（PV）重复单元的共轭低聚物（COE）可自发插入细胞膜中。研究了十二种COE（包括在此首次报道的七个结构）的膜破坏特性与结构修饰之间的关系，包括PV主链的长度和四烷基铵或吡啶鎓离子侧基的存在。光学特性和与细胞膜的相互作用使用紫外-可见吸收和光致发光光谱学和共聚焦显微镜确定。上代表革兰氏阳性（毒性试验粪肠球菌）和革兰氏阴性（大肠杆菌）细菌通常揭示更大的毒性，以粪肠球菌与对大肠杆菌的抗性相比，表明较短的分子具有优异的抗菌活性。在附有吡啶鎓离子基团的三环COE中观察到了抗菌效力的提高，但具有四个或五个PV重复单元的COE则未见到。对具有细胞被膜修饰的突变体的研究表明，与吡啶鎓附加的化合物之间可能存在基于电荷的相互作用。COE骨架上的氟取代导致对大肠杆菌毒性较小的结构，而在COE骨架上添加苯并噻二唑对增加抗菌功能没有影响。仅具有两个PV重复单元的弱膜插入COE允许我们确定在水

  DOI：

  10.1039/c6sc00630b
• 作为产物：
  描述：

  1,2,4,5-四氟-3-碘-6-甲基苯 生成 4,4'-二甲基八氟联苯
  参考文献：
  名称：

  聚氟苯基乙炔及相关化合物

  摘要：

  由五氟和4-取代的四氟碘苯（取代基R为CF 3-，H-，CH 3-或CH 3 O-）与铜（I）3-（2'-四氢吡喃氧基）丙-1的反应已获得相应的3-（聚氟苯基）丙-2-炔醇衍生物。其中R = N（CH 3）2-和NH 2-未获得炔属醇；这些是通过二甲胺和氨与3-（五氟苯基）丙-2-炔醇本身的反应合成的。通过在二恶烷/ NaOH水溶液中的过氧化镍将炔醇转化为相应的多氟苯基乙炔。用60℃的苯作为溶剂，将3-（五氟苯基）丙-2-炔醇氧化成醛和酸，在回流的苯中，得到1-4双（多氟苯基）丁二炔和多氟苯基乙炔。已经讨论了一些反应的机理。

  DOI：

  10.1016/0040-4020(76)85181-2

文献信息

• P ACTIVE MATERIALS FOR ORGANIC PHOTOELECTRIC CONVERSION LAYERS IN ORGANIC PHOTODIODES
  申请人：Sony Corporation

  公开号：US20210193935A1

  公开（公告）日：2021-06-24

  The present disclosure relates to transparent P materials and their use in absorption layer(s), photoelectric conversion layer(s) and/or an organic image sensor and methods for their synthesis.

  本公开涉及透明P材料及其在吸收层、光电转换层和/或有机图像传感器中的使用，以及它们的合成方法。
• [EN] IONOMERS WITH MACROCYCLIC MOIETIES FOR ION CONDUCTIVITY AND PERMSELECTIVITY<br/>[FR] IONOMÈRES À FRACTIONS MACROCYCLIQUES DESTINÉS À LA CONDUCTIVITÉ IONIQUE ET À LA PERMSÉLECTIVITÉ
  申请人：NUTECH VENTURES

  公开号：WO2021217175A1

  公开（公告）日：2021-10-28

  Provided here are ion conducting materials including one or more macrocycles, and either one or more pendant groups or one or more backbone repeat units. The ion conducting materials exhibit distinctly high ion conductivity in thin film and bulk membrane applications, and further exhibit one or more of ion permselectivity, mechanical strength, self-assembly, stacking, and gating behavior. Further provided are methods for preparation and methods for use of the ion conducting materials.

  这里提供了包括一个或多个大环、一个或多个挂链基团或一个或多个主链重复单元的离子导电材料。这些离子导电材料在薄膜和块体膜应用中表现出明显高的离子导电性，并且进一步表现出一个或多个离子选择透过性、机械强度、自组装、堆积和门控行为。此外，还提供了用于制备和使用离子导电材料的方法。
• 一种含有氟取代联苯的二苯乙烯衍生物及其制备方法、应用
  申请人：闽都创新实验室

  公开号：CN114230509A

  公开（公告）日：2022-03-25

  本发明提供了一种含有氟取代联苯的二苯乙烯衍生物及其制备方法、应用，选自具有式I所示结构式的化合物中的任一种。本发明在著名有机蓝光材料4,4’‑二[4‑(9‑咔唑基)苯乙烯基]联苯(BSBCz)的联苯位置引入氟原子从而获得了一种含有氟取代联苯的二苯乙烯衍生物，旨在利用引入的氟取代联苯结构增加材料的稳定性，调控材料的电子结构和光电性能。
• Perfluoro-1,1′-biphenyl and perfluoronaphthalene and their derivatives as π-acceptors for anions
  作者：Hai Yi、Markus Albrecht、Arto Valkonen、Kari Rissanen

  DOI：10.1039/c4nj01654h

  日期：——

  Addition of anions to perfluorinated 1,1′-biphenyl 1 or naphthalene 2 results in a shift of the 19F NMR signals. However, any specific interaction cannot be assigned to this effect. In order to study the interaction in more detail, the salt derivatives 3 and 4 were prepared and studied by single crystal X-ray diffraction revealing weak anion–π interactions in the solid state.

  将阴离子添加到全氟1,1'-联苯1或萘2中会导致19 F NMR信号偏移。但是，不能将任何特定的交互分配给该效果。为了更详细地研究相互作用，制备了盐衍生物3和4，并通过单晶X射线衍射进行了研究，揭示了固态中弱的阴离子-π相互作用。
• [EN] PEPTIDE OLIGONUCLEOTIDE CONJUGATES<br/>[FR] CONJUGUÉS PEPTIDES/OLIGONUCLÉOTIDES
  申请人：SAREPTA THERAPEUTICS INC

  公开号：WO2016187425A1

  公开（公告）日：2016-11-24

  Provided herein are oligonucleotides, peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.

  本文提供寡核苷酸、肽和肽-寡核苷酸共轭物。本文还提供了治疗肌肉疾病、病毒感染或细菌感染的方法，包括向需要治疗的受试者注射本文所描述的寡核苷酸、肽和肽-寡核苷酸共轭物。