氯西尼嗪 | 298-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氯西尼嗪
• 中文别名: 氯苯桂嗪；氯西尼嗪-D8
• 英文名称: 1-Cinnamyl-4-(4-chlor-benzhydryl)-piperazin
• 英文别名: 1-<4-Chlor-benzhydryl>-4-cinnamyl-piperazin；1-Cinnamyl-4-<4-chlor-benzhydryl>-piperazin；N-(α-Phenyl-p-chlor-benzyl)-N'-cinnamyl-piperazin；1-[(4-chlorophenyl)(phenyl)methyl]-4-cinnamylpiperazine；1-[(4-chlorophenyl)phenylmethyl]-4-(3-phenyl-2-propenyl)piperazine；1-(4-chloro-benzhydryl)-4-(3-phenyl-allyl)-piperazine；clocinizine；1-(p-Chloro-alpha-phenylbenzyl)-4-cinnamylpiperazine；1-[(4-chlorophenyl)-phenylmethyl]-4-(3-phenylprop-2-enyl)piperazine
• CAS: 298-55-5
• 化学式: C₂₆H₂₇ClN₂
• 分子量: 402.967
• InChiKey: ZSQANMZWGKYDER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯二苯氯甲烷 在 四丁基碘化铵 、 potassium carbonate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 10.25h， 生成 氯西尼嗪
  参考文献：
  名称：

  Efficient synthesis of antihistamines clocinizine and chlorcyclizine

  摘要：

  A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine (8), is prepared from (4-chlorophenyl) (phenyl)-methanone (5), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily.

  DOI：

  10.1007/s00044-011-9556-x

文献信息

• Efficient synthesis of antihistamines clocinizine and chlorcyclizine
  作者：A. Venkat Narsaiah、P. Narsimha

  DOI：10.1007/s00044-011-9556-x

  日期：2012.4

  A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine (8), is prepared from (4-chlorophenyl) (phenyl)-methanone (5), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily.