N-phenyl-N-isopropylacrylamide | 15315-38-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-N-isopropylacrylamide
• 英文别名: N-Phenyl-N-isopropyl-acrylamid；N-phenyl-N-propan-2-ylprop-2-enamide
• CAS: 15315-38-5
• 化学式: C₁₂H₁₅NO
• 分子量: 189.257
• InChiKey: IPIMLSRKICZJAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 N-phenyl-N-isopropylacrylamide 在 三乙烯二胺 、 苯酚 作用下， 以 水 、 叔丁醇 为溶剂， 生成
  参考文献：
  名称：

  Cascade synthesis of spirooxindole δ-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates

  摘要：

  A novel and highly efficient cascade synthesis of spirooxindole delta-lactone derivatives from N-aryl hydroxymethylacrylamides and xanthates in good yields is described. The reaction proceeds through a radical addition/cyclization and ester exchange, in which two new C-C bonds and one C-O bond were formed. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.08.039
• 作为产物：
  描述：

  N-异丙基苯胺 、 丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-phenyl-N-isopropylacrylamide
  参考文献：
  名称：

  Cascade synthesis of spirooxindole δ-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates

  摘要：

  A novel and highly efficient cascade synthesis of spirooxindole delta-lactone derivatives from N-aryl hydroxymethylacrylamides and xanthates in good yields is described. The reaction proceeds through a radical addition/cyclization and ester exchange, in which two new C-C bonds and one C-O bond were formed. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.08.039

文献信息

• Kinetics and Mechanism of the Nucleophilic Displacement Reactions of Chloroacetanilide Herbicides:  Investigation of α-Substituent Effects
  作者：Katrice A. Lippa、Sandra Demel、Irvin H. Lau、A. Lynn Roberts

  DOI：10.1021/jf030290d

  日期：2004.5.1

  ease with which alpha-chloroacetanilide herbicides undergo displacement reactions with strong nucleophiles, and their recalcitrance toward weak ones, is intimately related to their herbicidal properties and environmental chemistry. In this study, we investigate the kinetics and mechanisms of nucleophilic substitution reactions of propachlor and alachlor in aqueous solution. The role played by the alpha-amide

  α-氯代乙酰苯胺除草剂与强亲核体发生取代反应的难易程度以及对弱亲核体的拒服性与它们的除草特性和环境化学密切相关。在这项研究中，我们研究了水溶液中丙草胺和甲草胺的亲核取代反应的动力学和机理。通过包括具有修饰的α取代基的几种丙草胺的结构上相关的类似物，检查了α-酰胺基团所起的作用。反应的整体二级性质，负DeltaS（双匕首）值，离子强度对反应性的弱影响，结构反应性趋势共同支持分子间的S（N）2机理，而不是丙氯的α-氯代乙酰苯胺以及α-氯代硫代乙酰苯胺类似物的分子内反应。相反，α-亚甲基类似物表现出动力学和盐效应，与苯胺氮的邻氨基苯甲酸酯辅助相一致。可以推断出与α-苯胺取代基的电子相互作用，而不是与邻近基团的参与，可以控制α-氯乙酰苯胺对亲核试剂的反应性。
• COSMETIC COMPOSITION BASED ON A SUPRAMOLECULAR POLYMER AND A SILICONE COMPOUND
  申请人：L'Oréal

  公开号：EP2575970A2

  公开（公告）日：2013-04-10
• [EN] COSMETIC COMPOSITION BASED ON A SUPRAMOLECULAR POLYMER AND A SILICONE COMPOUND<br/>[FR] COMPOSITION COSMÉTIQUE BASÉE SUR UN POLYMÈRE SUPRAMOLÉCULAIRE ET UN COMPOSÉ DE SILICONE
  申请人：OREAL

  公开号：WO2011148324A2

  公开（公告）日：2011-12-01

  The present invention relates to a process for making up and/or caring for the skin and/or the lips, comprising the application to the skin and/or the lips of a cosmetic composition and in particular a composition for making up and/or caring for the skin and/or the lips, comprising at least one supramolecular polymer and a silicone compoirad with a viscosity of less than 10 000 000 cSt at 25°C,
• Cascade synthesis of spirooxindole δ-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates
  作者：Shucheng Wang、Xuhu Huang、Yanzhao Wen、Zemei Ge、Xin Wang、Runtao Li

  DOI：10.1016/j.tet.2015.08.039

  日期：2015.10

  A novel and highly efficient cascade synthesis of spirooxindole delta-lactone derivatives from N-aryl hydroxymethylacrylamides and xanthates in good yields is described. The reaction proceeds through a radical addition/cyclization and ester exchange, in which two new C-C bonds and one C-O bond were formed. (C) 2015 Elsevier Ltd. All rights reserved.