O-isobutyl-cholesterol | 25092-66-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: O-isobutyl-cholesterol
• 英文别名: 3β-Isobutyloxy-cholesten-(5)；O-Isobutyl-cholesterin；Isobutyl-cholesteryl-aether；(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-3-(2-methylpropoxy)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 25092-66-4
• 化学式: C₃₁H₅₄O
• 分子量: 442.769
• InChiKey: SDAPTPABRDENQQ-BWVDWJPHSA-N

物化性质

• 沸点：
  504.3±29.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异丁醇 、 cholesterol 在 Fuller's Earth 、 甲苯 作用下， 生成 O-isobutyl-cholesterol
  参考文献：
  名称：

  Relationship between Body Mass Index and the Use of Healthcare Services in Australia

  摘要：

  AbstractObjective: To examine the relationship between body mass index (BMI) and the use of medical and preventive health services.Research Methods and Procedures: This study involved secondary analysis of weighted data from the Australian 1995 National Health Survey. The study was a population survey designed to obtain national benchmark information about a range of health‐related issues. Data were available from 17,033 men and 17,174 women, ≥20 years or age. BMI, based on self‐reported weight and height, was analyzed in relation to the use of medical services and preventive health services.Results: A positive relationship was found between BMI and medical service use, such as medication use, visits to hospital accident and emergency departments (for women only); doctor visits, visits to a hospital outpatient clinics; and visits to other health professionals (for women only). A negative relationship was found in women between BMI and preventive health services. Underweight women were found to be significantly less likely to have Papanicolaou smear tests, breast examinations, and mammograms.Discussion: This research shows that people who fall outside the healthy weight range are more likely to use a range of medical services. Given that the BMI of industrialized populations appears to be increasing, this has important ramifications for health service planning and reinforces the need for obesity prevention strategies at a population level.

  DOI：

  10.1038/oby.2002.71

文献信息

• Implants for localized drug delivery and methods of use thereof
  申请人：The Regents of the University of California

  公开号：US10912933B2

  公开（公告）日：2021-02-09

  Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.

  本文提供了一种向目标组织输送疏水活性剂的植入物。该植入物可包括界定第一表面和与第一表面相对的第二表面的支架，其中支架基本上不渗透疏水活性剂，以及具有可渗透活性剂壁的硅胶管，其中硅胶管的第一长度贴在支架的第一表面上，其中硅胶管的两端从第一表面延伸，并且第一长度内的第二长度的硅胶管所勾勒的路径是迂回的。此外，还提供了一种使用植入物向目标组织局部递送疏水活性剂的方法，以及可用于实施本方法的试剂盒。
• A facile etherification procedure for 3β-hydroxy-Δ5-steroids
  作者：John P. Dasza、Joseph P. Joseph、Seymour Bernstein

  DOI：10.1016/0039-128x(66)90045-6

  日期：1966.10
• Cremlyn,R.J.W. et al., Phosphorus and the Related Group V Elements, 1976, vol. 6, p. 201 - 205
  作者：Cremlyn,R.J.W. et al.

  DOI：——

  日期：——
• IMPLANTS FOR LOCALIZED DRUG DELIVERY AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：EP3183026A1

  公开（公告）日：2017-06-28
• Implants for Localized Drug Delivery and Methods of Use Thereof
  申请人：KIRIAKIS Jim

  公开号：US20170224970A1

  公开（公告）日：2017-08-10

  Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.