胆固醇丙醚 | 10322-02-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 胆固醇丙醚
• 中文别名: 5-胆甾烯-3Β-醇3-丙醚；3Β-丙氧基-5-胆甾烯；3Β-羟基-5-胆甾烯3-丙醚
• 英文名称: cholesterol propyl ether
• 英文别名: O-propyl-cholesterol；3β-Propyloxy-cholesten-(5)；O-Propyl-cholesterin；Propyl-cholesteryl-aether；Cholesterylpropylether；Cholesteryl propyl ether；(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-3-propoxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 10322-02-8
• 化学式: C₃₀H₅₂O
• 分子量: 428.742
• InChiKey: BBQNHGBERIULCP-OCBUSCMESA-N

物化性质

• 熔点：
  99.5-100.5 °C(Solv: acetone (67-64-1))
• 沸点：
  495.3±24.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  O-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] propanethioate 在 偶氮二异丁腈 、 三苯基氢化锡 作用下， 以 甲苯 为溶剂， 反应 0.33h， 以93%的产率得到胆固醇丙醚
  参考文献：
  名称：

  Conversion of thionoesters and thionolactones to ethers; a general and efficient radical desulfurisation

  摘要：

  三苯锡氢将硫代酯和硫代内酯高效还原为其相应的醚。

  DOI：

  10.1039/c39950001583

文献信息

• Reactions of relevance to the chemistry of aminoglycoside antibiotics. Part 8. Synthesis and properties of O-alkyl selenoesters
  作者：Derek H. R. Barton、Per-Egil Hansen、Kelvin Picker

  DOI：10.1039/p19770001723

  日期：——

  from the appropriate di-N-substituted imidoyl chloride with use of sodium hydrogen selenide to introduce selenium. The reduction of selenoesters to ethers has been demonstrated, as well as the ready reaction of these compounds with the methylene Wittig reagent.

  由适当的二-N-取代的亚氨基酰氯，利用硒化氢钠引入硒，已经合成了多种脂族和芳族的O-烷基硒酸酯。已经证明了硒酸酯还原成醚，以及这些化合物与亚甲基维蒂希试剂的现成反应。
• Studies of organophosphorochloridates. Part VI. Reactions of steroid phosphorochloridates with amines and some alcohols
  作者：R. J. W. Cremlyn、B. B. Dewhurst、D. H. Wakeford、R. A. Raja

  DOI：10.1039/p19720001171

  日期：——

  Cholesteryl phosphorodichloridate is best prepared by the action of phosphoryl chloride on cholesterol in the presence of triethylamine. Chromatography and thermal decomposition of the phosphorodichloridate are briefly discussed. Cholesteryl, lanosteryl, and ergosteryl phosphorodichloridates have been treated with selected primary and secondary amines. In all cases nucleophilic substitution at the

  最好在三乙胺存在下，通过磷酰氯对胆固醇的作用来制备磷酸二氯胆固醇酯。简要讨论了二氯化磷的色谱和热分解。胆固醇，羊毛甾醇和麦角甾二磷酸二氯酯已用选定的伯胺和仲胺进行了处理。在所有情况下，磷原子上都发生了亲核取代；仅具有麦角甾醇衍生物的在C-3处被消除。
• A mild procedure for etherification of alcohols with primary alkyl halides in the presence of silver triflate
  作者：Robert M. Burk、Todd S. Gac、Michael B. Roof

  DOI：10.1016/0040-4039(94)88256-8

  日期：1994.10

  Alcohols were alkylated in good to excellent yield with primary alkyl halides by a method employing silver triflate and a non-nucleophilic amine base.

  通过使用三氟甲磺酸银和非亲核胺碱的方法，用伯烷基卤化物将醇以良好或极好的收率烷基化。
• LIPID-BASED PLATINUM COMPOUNDS AND NANOPARTICLES
  申请人：INVICTUS ONCOLOGY PVT. LTD.

  公开号：US20160145284A1

  公开（公告）日：2016-05-26

  The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

  本公开涉及纳米技术和癌症治疗领域。特别地，本公开涉及包含铂基团、链接基团和脂质基团的铂基化合物及其相应的纳米粒子。本公开还涉及所述铂基化合物、纳米粒子的合成和包含所述铂基化合物/纳米粒子的组合物。本公开还涉及使用上述卡宾化合物、铂基化合物、纳米粒子和其组合物治疗癌症的方法。
• Implants for localized drug delivery and methods of use thereof
  申请人：The Regents of the University of California

  公开号：US10912933B2

  公开（公告）日：2021-02-09

  Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.

  本文提供了一种向目标组织输送疏水活性剂的植入物。该植入物可包括界定第一表面和与第一表面相对的第二表面的支架，其中支架基本上不渗透疏水活性剂，以及具有可渗透活性剂壁的硅胶管，其中硅胶管的第一长度贴在支架的第一表面上，其中硅胶管的两端从第一表面延伸，并且第一长度内的第二长度的硅胶管所勾勒的路径是迂回的。此外，还提供了一种使用植入物向目标组织局部递送疏水活性剂的方法，以及可用于实施本方法的试剂盒。