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(4-Oxo-1,3-dioxolan-5-ylidene)diacetyl chloride | 81505-61-5

中文名称
——
中文别名
——
英文名称
(4-Oxo-1,3-dioxolan-5-ylidene)diacetyl chloride
英文别名
4-oxo-1.3-dioxolane-5,5-bis(acetylchloride);anhydromethylenecitryl chloride;methylenecitryl chloride;5,5-bis-chlorocarbonylmethyl-[1,3]dioxolan-4-one;5,5-Bis-chlorcarbonylmethyl-[1,3]dioxolan-4-on;Methylencitronensaeure-dichlorid;2-[4-(2-chloro-2-oxoethyl)-5-oxo-1,3-dioxolan-4-yl]acetyl chloride
(4-Oxo-1,3-dioxolan-5-ylidene)diacetyl chloride化学式
CAS
81505-61-5
化学式
C7H6Cl2O5
mdl
——
分子量
241.028
InChiKey
OYXNKSBWMFELAT-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    364.4±17.0 °C(Predicted)
  • 密度:
    1.526±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    0.57
  • 重原子数:
    14.0
  • 可旋转键数:
    4.0
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.57
  • 拓扑面积:
    69.67
  • 氢给体数:
    0.0
  • 氢受体数:
    5.0

SDS

SDS:fa16620f120c0a869dfea2432fd8c5a8
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上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    (4-Oxo-1,3-dioxolan-5-ylidene)diacetyl chloride 在 palladium on activated charcoal 氢气三乙胺 作用下, 以 四氢呋喃氯仿 为溶剂, 25.0 ℃ 、101.33 kPa 条件下, 反应 3.08h, 生成 Arthrobactin A
    参考文献:
    名称:
    Synthesis of novel citrate-based siderophores and siderophore-.beta.-lactam conjugates. Iron transport-mediated drug delivery systems
    摘要:
    The synthesis of analogs of arthrobactin (5), a microbial iron chelator, and its imide 8 are described. The differentially protected citric acid residue 31 served as the key intermediate in making conjugates having a generalized structure 14 with two representative carbacephalosporin units, 15 and 16. Both conjugates, 49 and 51, showed antibiotic activity, while conjugate 51 obtained from beta-lactam 16 bearing a phenylglycyl side chain was shown to be more effective.
    DOI:
    10.1021/jo00079a007
  • 作为产物:
    描述:
    brucine; salt of/the/ (5-oxo-[1,3]dioxolane-4,4-diyl)-di-acetic acid 在 五氯化磷 作用下, 生成 (4-Oxo-1,3-dioxolan-5-ylidene)diacetyl chloride
    参考文献:
    名称:
    DE186659
    摘要:
    公开号:
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文献信息

  • Diaspirins of Methylenecitric Acid
    作者:Solomon E. Massil、Guey-Yueh Shi、Irving M. Klotz
    DOI:10.1002/jps.2600730338
    日期:1984.3
    A series of bissalicylic esters of methylenecitric acid have been prepared and, as a probe of their potential as antisickling agents, tested for their ability to modify hemoglobin. Substantial acylation of hemoglobin was obtained with these dicarboxylate esters at 1-5 mM concentrations.
    已经制备了一系列的亚甲基柠檬酸水杨酸酯,并作为其作为抗溶血剂的潜力的探针,测试了它们修饰血红蛋白的能力。用这些二羧酸酯以1-5mM的浓度获得了血红蛋白的大量酰化。
  • DE193114
    申请人:——
    公开号:——
    公开(公告)日:——
  • Prevalence and etiology of vertigo in adult rural population
    作者:Raman Abrol、Vikas I. Nehru、Y. Venkatramana
    DOI:10.1007/bf02910976
    日期:2001.1
    A survey on 10.000 adults between the age of 20 and 79 years out of a total population of 66.186 persons in rural settlements under the inrisduction of Union Territory of Chandigarh between June 1993 to June 1995 was conducted to find out the prevalence and various causes of vertigo. In general community, in rural population, we found that more people suffer from non-otologic vertigo rather than otologic vertigo. We found overall prevalence of vertigo in rural adult community to be 0.71%. Vertigo secondary to cardiovascular disease was most common and prevalent in 0.32% of population. Neurologic disease accounted for vertigo in 0.14%, metabolic disease in 0.09% and otologic disease 0.08%. Miscellaneous disorders were present in remaining 0.08% of population studied. To the best of our knowledge this study represents the first population based survey of prevalence of various causes of vertigo in general community in adult rural population.
  • Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N6-acetyl-N6-hydroxylysine
    作者:Peter J. Maurer、Marvin J. Miller
    DOI:10.1021/ja00375a025
    日期:1982.6
  • Natural ferric ionophores: total synthesis of schizokinen, schizokinen A, and arthrobactin
    作者:Byung Hyun Lee、Marvin J. Miller
    DOI:10.1021/jo00149a005
    日期:1983.1
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