N-(2-nitropyridin-3-yl)formamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-nitropyridin-3-yl)formamide
• 英文别名: 2-nitro-3-formamido pyridine
• 化学式: C₆H₅N₃O₃
• 分子量: 167.124
• InChiKey: NQWLOINFSUNPLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-nitropyridin-3-yl)formamide 在 甲醇 、 potassium carbonate 、 copper(II) sulfate 、 sodium ascorbate 作用下， 以 水 、 丙酮 、 甲苯 、 乙腈 为溶剂， 反应 0.58h， 生成 C₁₀H₁₁⁽¹⁸⁾FN₆O₂
  参考文献：
  名称：

  A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

  摘要：

  Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with short-lived radionuclides (e. g., F-18 for PET). A significant drawback of radiopharmaceuticals development is the difficulty to access radiolabeled molecule libraries for initial in vitro evaluation, as radiolabeling has to be optimized for each individual molecule. The present paper discloses a method for preparing libraries of F-18-labeled radiopharmaceuticals using both the fluorous-based F-18-radiochemistry and the Huisgen 1,3-dipolar (click) conjugation reaction. As a proof of concept, this approach allowed us to obtain a series of readily accessible F-18-radiolabeled nitroaromatic molecules, for exploring their structure-activity relationship and further in vitro evaluation of their hypoxic selectivity. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.084
• 作为产物：
  描述：

  3-氨基-2-硝基吡啶 、 甲乙酐 以 乙醚 为溶剂， 以623 mg的产率得到N-(2-nitropyridin-3-yl)formamide
  参考文献：
  名称：

  A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

  摘要：

  Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with short-lived radionuclides (e. g., F-18 for PET). A significant drawback of radiopharmaceuticals development is the difficulty to access radiolabeled molecule libraries for initial in vitro evaluation, as radiolabeling has to be optimized for each individual molecule. The present paper discloses a method for preparing libraries of F-18-labeled radiopharmaceuticals using both the fluorous-based F-18-radiochemistry and the Huisgen 1,3-dipolar (click) conjugation reaction. As a proof of concept, this approach allowed us to obtain a series of readily accessible F-18-radiolabeled nitroaromatic molecules, for exploring their structure-activity relationship and further in vitro evaluation of their hypoxic selectivity. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.084

文献信息

• Azahydroxybenzotriazoles and derivatives thereof for peptide coupling
  申请人：Research Corporation Technologies, Inc.

  公开号：US05580981A1

  公开（公告）日：1996-12-03

  This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: ##STR1## and N-oxides thereof and salts thereof.

  这项发明涉及一种从氨基或醇分别与羧酸的酰化衍生物在有效量的化合物存在下反应形成酰胺或酯的过程，所述化合物具有以下结构式：##STR1##以及其N-氧化物和盐。
• REAGENTS FOR PEPTIDE COUPLINGS
  申请人：RESEARCH CORPORATION TECHNOLOGIES, INC.

  公开号：EP0662078B1

  公开（公告）日：2003-05-02
• NEW REAGENTS FOR PEPTIDE COUPLINGS
  申请人：Research Corporation Technologies, Inc.

  公开号：EP0662078A1

  公开（公告）日：1995-07-12
• US5580981A
  申请人：——

  公开号：US5580981A

  公开（公告）日：1996-12-03
• US5644029A
  申请人：——

  公开号：US5644029A

  公开（公告）日：1997-07-01