N-[5-(1,3-dioxoisoindol-2-yl)-1-[oxido(diphenoxy)phosphaniumyl]pentyl]formamide | 901773-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-[5-(1,3-dioxoisoindol-2-yl)-1-[oxido(diphenoxy)phosphaniumyl]pentyl]formamide
• CAS: 901773-74-8
• 化学式: C₂₆H₂₅N₂O₆P
• 分子量: 492.468
• InChiKey: XGOWNTNPPRWABB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[5-(1,3-dioxoisoindol-2-yl)-1-[oxido(diphenoxy)phosphaniumyl]pentyl]formamide 在 三乙胺 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以94%的产率得到2-[5-Isocyano-5-[oxido(diphenoxy)phosphaniumyl]pentyl]isoindole-1,3-dione
  参考文献：
  名称：

  Synthesis of isocyanide derivatives of α-aminoalkylphosphonate diphenyl esters

  摘要：

  This letter describes the first example of the synthesis of isocyanide derivatives of alpha-aminoalkylphosphonate diphenyl esters. This method produces the title compounds in high purity and in very good yields. It also permits the generation of an alpha-aminophosphonate-based library of biologically active phosphonopeptides. Preliminary experiments demonstrate their application as substrates for the Ugi-type multicomponent condensation. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.058
• 作为产物：
  描述：

  5-phthalimido-1-pentanal 在 氢溴酸 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 溶剂黄146 为溶剂， 反应 0.5h， 生成 N-[5-(1,3-dioxoisoindol-2-yl)-1-[oxido(diphenoxy)phosphaniumyl]pentyl]formamide
  参考文献：
  名称：

  Synthesis of isocyanide derivatives of α-aminoalkylphosphonate diphenyl esters

  摘要：

  This letter describes the first example of the synthesis of isocyanide derivatives of alpha-aminoalkylphosphonate diphenyl esters. This method produces the title compounds in high purity and in very good yields. It also permits the generation of an alpha-aminophosphonate-based library of biologically active phosphonopeptides. Preliminary experiments demonstrate their application as substrates for the Ugi-type multicomponent condensation. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.058

文献信息

• Synthesis of isocyanide derivatives of α-aminoalkylphosphonate diphenyl esters
  作者：Marcin Sieńczyk、Maciej Kliszczak、Józef Oleksyszyn

  DOI：10.1016/j.tetlet.2006.04.058

  日期：2006.6

  This letter describes the first example of the synthesis of isocyanide derivatives of alpha-aminoalkylphosphonate diphenyl esters. This method produces the title compounds in high purity and in very good yields. It also permits the generation of an alpha-aminophosphonate-based library of biologically active phosphonopeptides. Preliminary experiments demonstrate their application as substrates for the Ugi-type multicomponent condensation. (c) 2006 Elsevier Ltd. All rights reserved.