双(2,4-二氯苯基)甲酮 | 25187-08-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双(2,4-二氯苯基)甲酮
• 英文名称: 2,4,2',4'-Tetrachlor-benzophenon
• 英文别名: Bis(2,4-dichlorophenyl)methanone
• CAS: 25187-08-0
• 化学式: C₁₃H₆Cl₄O
• mdl: MFCD00051925
• 分子量: 320.002
• InChiKey: SCBBVCPZAKTFJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  双(2,4-二氯苯基)甲酮 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 bis(2,4-dichlorophenyl)methanol
  参考文献：
  名称：

  联苯苄唑衍生物的合成、抗菌和抗真菌活性

  摘要：

  合成了两个系列的氯化二苯甲基咪唑和三唑衍生物，并针对强致病菌的代表性菌株（金黄色葡萄球菌 CIP 4.83、伊氏埃希氏菌 CIP 5855、铜绿假单胞菌 CIP 82118、大肠杆菌CIP 和真菌 IP 53126）进行了体外测试白色念珠菌 IP 48.72、克柔念珠菌 IP 208.52、红色毛癣菌 IP 1657.86)。这些化合物中的大多数没有任何抗菌活性，但其中一些抑制红色毛癣菌的 MIC 值在 0.125 至 32 µg/mL 范围内，类似于或优于联苯苄唑和克霉唑，用作标准对照。在这些化合物中用三唑部分取代咪唑环导致抗真菌活性较低的衍生物。

  DOI：

  10.1002/ardp.201000304
• 作为产物：
  描述：

  dichloro-bis-(2,4-dichloro-phenyl)-methane 在 硫酸 、 溶剂黄146 作用下， 反应 1.0h， 生成 双(2,4-二氯苯基)甲酮
  参考文献：
  名称：

  1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, New Imidazoles with Potent Activity againstCandida albicansand Dermatophytes. Synthesis, Structure−Activity Relationship, and Molecular Modeling Studies

  摘要：

  New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 mu g/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC <= 5 mu g/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.

  DOI：

  10.1021/jm800009r

文献信息

• Quinazoline derivatives useful in cancer treatment
  申请人：Mallams K. Alan

  公开号：US20070015774A1

  公开（公告）日：2007-01-18

  The present invention provides compounds of Formula I (wherein R 1 , R 2 , R 3 , L, and X are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.

  本发明提供了式I的化合物（其中R1、R2、R3、L和X如本文所定义）。或其药用可接受的盐、溶剂或酯。本发明还提供了包含这些化合物的组合物，用于治疗细胞增殖性疾病、与p53突变体活性有关的疾病，或导致癌细胞凋亡。
• Analgesic imidazolemethanols
  申请人：Gist-Brocades N.V.

  公开号：US04152441A1

  公开（公告）日：1979-05-01

  .alpha.,.alpha.-Diarylimidazole-2-methanols of the general formula ##STR1## wherein R.sub.1 -R.sub.10 are the same or different and each represents a hydrogen or halogen atom or a trifluoromethyl or tertiary butyl group, with at least one of said R.sub.1 -R.sub.10 being halogen, trifluoromethyl or tertiary butyl; R.sub.11 and R.sub.12 are the same or different and each represents a hydrogen atom, an alkyl group, a phenyl group or a halogen-or trifluoromethyl-substituted phenyl group; and R.sub.13 represents a hydrogen atom or a lower alkyl group, a lower alkoxymethyl group, a phenylalkyl group (optionally substituted in the phenyl moiety by one or more halogen atoms or alkyl or trifluoromethyl groups), an alkenyl group, a phenyl(lower)alkoxymethyl group (optionally substituted in the phenyl moiety by one or more halogen atoms or alkyl or trifluoromethyl groups) or a benzenesulfonyl group (in which the phenyl moiety is optionally substituted by one or more alkyl groups) are described. These compounds and their non-toxic acid addition salts have anorexient activity. Certain of these compounds have analgesic activity comparable to morphine but without its serious side effects. Processes for their manufacture and compositions for their use are described.

  通用公式##STR1##中的.alpha.，.alpha.-二日记亚咪唑-2-甲醇，其中R.sub.1 -R.sub.10相同或不同，每个代表氢或卤素原子或三氟甲基或叔丁基基团，其中至少一个R.sub.1 -R.sub.10为卤素、三氟甲基或叔丁基；R.sub.11和R.sub.12相同或不同，每个代表氢原子、烷基、苯基或卤素或三氟甲基取代的苯基；R.sub.13代表氢原子或较低烷基基团、较低烷氧甲基基团、苯基烷基基团（苯基部分可由一个或多个卤素原子或烷基或三氟甲基基团取代）、烯基基团、苯基（较低）烷氧甲基基团（苯基部分可由一个或多个卤素原子或烷基或三氟甲基基团取代）或苯磺酰基团（其中苯基部分可由一个或多个烷基基团取代）的描述。这些化合物及其无毒酸盐具有厌食活性。其中某些化合物具有与吗啡相当的镇痛活性，但没有其严重的副作用。描述了其制造过程和用途组成。
• A palladium-catalyzed C–H functionalization route to ketones <i>via</i> the oxidative coupling of arenes with carbon monoxide
  作者：Taleah M. Levesque、R. Garrison Kinney、Bruce A. Arndtsen

  DOI：10.1039/d0sc00085j

  日期：——

  development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes.

  我们描述了一种新的钯催化方法的发展，该方法通过两个芳烃和一氧化碳的氧化偶联生成酮。这种转化是由简单的钯盐催化的，并且被认为是通过将芳烃转化为高能的芳基三氟甲磺酸酯亲电子试剂来进行的。利用后者还可以从两个不同的芳烃合成不对称的酮。
• Poly(arylene thioether-ketone) fibers and production process thereof
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0293114A2

  公开（公告）日：1988-11-30

  Disclosed herein are poly(arylene thioether-­ketone) fibers obtained by melt-spinning a thermo­plastic material which comprises 100 parts by weight of a melt-stable poly(arylene thioether-ketone) (PTK) and optionally, up to 50 parts by weight of at least one of thermoplastic resins. The PTK has predominant recurring units of the formula, wherein the -CO- and -S- are in the para position to each other, and has a melting point, Tm of 310-380°C, a residual melt crystallization enthalpy, ΔHmc (420°C/10 min) of at least 10 J/g, a melt crystalliza­tion temperature, Tmc (420°C/10 min) of at least 210°C, and a reduced viscosity of 0.3-2 dℓ/g as determined by viscosity measurement at 25°C and a polymer concentration of 0.5 g/dℓ in 98 percent by weight sulfuric acid. The PTK fibers of this invention have high heat resistance and strength.

  本发明公开了通过熔融纺丝热塑性材料获得的聚（芳基硫醚酮）纤维，该热塑性材料由 100 重量份的熔融稳定的聚（芳基硫醚酮）（PTK）和最多 50 重量份的至少一种热塑性树脂组成。PTK 的主要重复单元式为 其中 -CO- 和 -S- 互为对位，熔点 Tm 为 310-380°C，残余熔融结晶焓 ΔHmc (420°C/10 min) 至少为 10 J/g，熔融结晶温度 Tmc (420°C/10 min) 至少为 210°C，还原粘度为 0.3-2 dℓ/g，该粘度是在 25°C 和聚合物浓度为 0.5 g/dℓ 的 98% 重量百分比的硫酸中通过粘度测量确定的。本发明的 PTK 纤维具有较高的耐热性和强度。
• Aromatic polycarbonate resins and process for the preparation thereof
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0584801A2

  公开（公告）日：1994-03-02

  Disclosed herein is an aromatic polycarbonate resin containing benzophenone and benzoate ester derivatives which have a molecular weight less than 1,000, each in an amount of 100 ppm or less. Also disclosed is a process for preparing an aromatic polycarbonate resin from an aromatic dihydroxy compound and a carbonate diester in which the benzophenone derivative content is 100 ppm or less by transesterification, comprising preparing a polycarbonate prepolymer having a viscosity average molecular weight of 5,000 to 20,000 using an iminocarboxylic acid or salt thereof as a transesterification catalyst and polymerizing the prepolymer in an extruder. Phosphoric acid mono- or diesters, phosphorous acid diesters or phosphorous acid are optionally added as stabilizers during the preparation process. The aromatic polycarbonate is colorless and transparent and is suitable for extrusion molding.

  本发明公开了一种芳香族聚碳酸酯树脂，其中含有二苯甲酮和苯甲酸酯衍生物，这两种衍生物的分子量小于 1,000，含量均为 100 ppm 或更少。本发明还公开了一种通过酯交换反应从芳香族二羟基化合物和碳酸酯二酯制备芳香族聚碳酸酯树脂的工艺，其中二苯甲酮衍生物含量为 100 ppm 或更少，该工艺包括使用亚氨基甲酸酯或其盐作为酯交换反应催化剂制备粘度平均分子量为 5,000 至 20,000 的聚碳酸酯预聚物，并在挤压机中聚合该预聚物。在制备过程中，可选择添加磷酸单酯或磷酸二酯、磷酸二酯或磷酸作为稳定剂。 芳香族聚碳酸酯无色透明，适合挤出成型。