3-phenylamino-N-phenyl-benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenylamino-N-phenyl-benzamide
• 英文别名: 3-anilino-N-phenylbenzamide
• 化学式: C₁₉H₁₆N₂O
• 分子量: 288.349
• InChiKey: SYAJJFXDXYXJLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氨基苯甲酰苯胺 、 三苯基铋 在 copper diacetate 盐酸 、 三乙胺 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 生成 3-phenylamino-N-phenyl-benzamide
  参考文献：
  名称：

  Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis

  摘要：

  本发明提供了化合物的结构式（I）。本发明还提供了治疗或预防炎症或动脉粥样硬化的方法，以及含有结构式（I）化合物的药物组合物。

  公开号：

  US06268387B1

文献信息

• Palladium- and Nickel-Catalyzed Amination of Aryl Fluorosulfonates
  作者：Patrick S. Hanley、Thomas P. Clark、Arkady L. Krasovskiy、Matthias S. Ober、John P. O’Brien、Tina S. Staton

  DOI：10.1021/acscatal.6b00865

  日期：2016.6.3

  nickel-catalyzed amination of aryl fluorosulfonates with aromatic and alkyl amines are described. Aniline is coupled to a diverse series of aryl fluorosulfonates catalyzed by the combination of CpPd(cinammyl) and Xantphos, and the relative reactivity of aryl fluorosulfonates to undergo Pd-catalyzed amination was compared with other common aryl electrophiles. In addition, we report the direct amination of a phenol

  描述了芳族氟磺酸与芳族和烷基胺的钯和镍催化的胺化的实例。苯胺与CpPd（肉桂醛）和Xantphos的组合催化的一系列芳基氟磺酸盐偶联，并与其他常见的芳基亲电试剂比较了芳基氟磺酸盐进行Pd催化胺化反应的相对反应性。另外，我们报道了通过与硫酰氟和碱反应原位形成氟代磺酸芳基酯而直接胺化苯酚，随后胺化以形成新的C–N键的方法。最后，我们报告了镍（COD）2的组合镍催化的氟代芳基磺酸盐的胺化反应的实例。和在MeCN存在下的DPPF。氟磺酸芳基酯亲电试剂与普通的钯和镍催化剂体系的高反应活性，再加上由硫磺酰氟的简单制备方法，将能够实现丰富的酚醛原料的工业化胺化反应。
• [EN] METHOD FOR COUPLING A FLUOROSULFONATE COMPOUND WITH AN AMINE COMPOUND<br/>[FR] PROCÉDÉ DE COUPLAGE D'UN FLUOROSULFONATE AVEC UNE AMINE
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2016057770A1

  公开（公告）日：2016-04-14

  The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and reacting the first compound and the second compound in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture under conditions effective to couple the first compound to the second compound. The present disclosure further describes a one-pot method for coupling a first compound to a second compound.

  本公开说明描述了一种将第一化合物与第二化合物偶联的方法，该方法包括：提供具有氟磺酸酯取代基的第一化合物；提供包含胺基的第二化合物；在反应混合物中反应第一化合物和第二化合物，反应混合物包括至少一个第10族元素的催化剂，在有效偶联第一化合物和第二化合物的条件下进行反应。本公开说明还描述了一种一锅法将第一化合物与第二化合物偶联的方法。
• Selective <i>N</i>-Arylation of Aminobenzanilides under Mild Conditions Using Triarylbismuthanes
  作者：Roderick J. Sorenson

  DOI：10.1021/jo000614m

  日期：2000.11.1

  Diarylamines are prepared selectively in good yields under mild conditions by treatment of aminobenzanilides with triarylbismuthanes in the presence of copper(II) acetate and triethylamine. Arylation under these conditions occurs preferentially at the amino- rather than the amide-nitrogen of the benzanilide. Thus, heating an aminobenzanilide in dichloromethane under reflux in the presence of 1 equiv each of a triarylbismuthane, triethylamine, and copper(II) acetate affords the diarylamine in good yields. This method thereby provides a mild and expeditious route to functionalized diarylamines.
• THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1042276A1

  公开（公告）日：2000-10-11
• METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND
  申请人：Dow Global Technologies LLC

  公开号：US20170210695A1

  公开（公告）日：2017-07-27

  The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and reacting the first compound and the second compound in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture under conditions effective to couple the first compound to the second compound. The present disclosure further describes a one-pot method for coupling a first compound to a second compound.