N-(4'-carboxyphenyl)-3,6-dinitro-1,8-naphthalimide | 330590-40-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4'-carboxyphenyl)-3,6-dinitro-1,8-naphthalimide
• 英文别名: 4-(5,8-dinitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzoic acid；4-(5,8-dinitro-1,3-dioxobenzo[de]isoquinolin-2-yl)benzoic acid
• CAS: 330590-40-4
• 化学式: C₁₉H₉N₃O₈
• mdl: MFCD00339190
• 分子量: 407.296
• InChiKey: FDRBLHSYBLXGRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  166
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-(4'-carboxyphenyl)-3,6-dinitro-1,8-naphthalimide 在 palladium 10% on activated carbon 、 氢气 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 25.0 ℃ 、100.0 kPa 条件下， 反应 16.0h， 生成 4-(5,8-Diamino-1,3-dioxobenzo[de]isoquinolin-2-yl)benzoic acid
  参考文献：
  名称：

  The synthesis and fluorescence properties of macromolecular components based on 1,8-naphthalimide derivatives and dimers

  摘要：

  A series of novel 1,8-naphthalimide derivatives and dimers possessing reactive carboxylic acid, nitro, amine, or bromide functionality is prepared and their photophysical properties are studied. Those derivatives that contain amine substituents attached directly to the 1,8-naphthalimide unit display intense yellow-green fluorescence. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.009
• 作为产物：
  描述：

  3,6-dinitro-1,8-naphthalic anhydride 、 对氨基苯甲酸 在 sodium acetate 、 溶剂黄146 作用下， 以93%的产率得到N-(4'-carboxyphenyl)-3,6-dinitro-1,8-naphthalimide
  参考文献：
  名称：

  The synthesis and fluorescence properties of macromolecular components based on 1,8-naphthalimide derivatives and dimers

  摘要：

  A series of novel 1,8-naphthalimide derivatives and dimers possessing reactive carboxylic acid, nitro, amine, or bromide functionality is prepared and their photophysical properties are studied. Those derivatives that contain amine substituents attached directly to the 1,8-naphthalimide unit display intense yellow-green fluorescence. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.009

文献信息

• Methods of modulating neurotrophin-mediated activity
  申请人：Babinski Kazimierz

  公开号：US20070123514A1

  公开（公告）日：2007-05-31

  Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

  本发明揭示了一种调节神经生长因子及其前体与神经营养因子受体相互作用的组合物。本发明还揭示了使用该组合物的方法，包括给药方法。
• [EN] METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY<br/>[FR] METHODES DE MODULATION DE L'ACTIVITE INDUITE PAR LA NEUROTROPHINE
  申请人：PAINCEPTOR PHARMA CORP

  公开号：WO2007030939A2

  公开（公告）日：2007-03-22

  [EN] Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.
  [FR] La présente invention concerne des compositions qui modulent l'interaction avec le facteur de croissance nerveuse et des précurseurs de celui-ci au moyen de récepteurs neurotrophiques. Cette invention concerne également des méthodes d'utilisation des compositions de cette invention, y compris des méthodes d'administration.