4-氨基苯甲酸盐酸盐 | 22669-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基苯甲酸盐酸盐
• 英文名称: p-aminobenzoic acid hydrochloride
• 英文别名: 4-aminobenzoic acid hydrochloride；4-Carboxyanilinium chloride；(4-carboxyphenyl)azanium;chloride
• CAS: 22669-27-8
• 化学式: C₇H₇NO₂*ClH
• 分子量: 173.599
• InChiKey: KBCPMQUSOLSAQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温，惰性气体

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : 4-AMINOBENZOIC ACID HYDROCHLORIDE
CAS-No. : 22669-27-8
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Skin irritation (Category 2)
Eye irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Irritating to eyes, respiratory system and skin.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s)
P261 Avoid breathing dust.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R36/37/38 Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C7H8ClNO2
Molecular Weight : 173,6 g/mol
Component Concentration
4-AMINOBENZOIC ACID HYDROCHLORIDE
CAS-No. 22669-27-8 -

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIRE-FIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at
the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the
standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use
respirators and components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-氨基苯甲酸盐酸盐 在 亚硝酸乙酯 、 ammonium persulfate 、 溴 作用下， 以 乙醇 、 四氯化碳 、 乙醚 为溶剂， 反应 0.75h， 生成 4-溴苯甲酸
  参考文献：
  名称：

  A Novel Synthesis of Bromobenzenes Using Molecular Bromine

  摘要：

  某些取代溴苯在可接受的产率下通过一种新型的桑德迈尔反应合成。这些反应相对较快，并可能通过自由基机制进行。

  DOI：

  10.3390/12112478
• 作为产物：
  描述：

  对硝基苯甲酸 在 iron(III) acetylacetonate 、 1,1,3,3-四甲基二硅氧烷 、 盐酸 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 24.08h， 以73%的产率得到4-氨基苯甲酸盐酸盐
  参考文献：
  名称：

  使用TMDS-铁催化剂体系将芳族硝基还原为胺的替代方法

  摘要：

  本文报道了系统1,1,3,3-四甲基二硅氧烷（TMDS）/ Fe（acac）3作为从芳族硝基化合物获得胺的新方法。胺可通过简单的步骤进行合成，并以良好或极好的收率分离为盐酸盐形式。该系统显示出对芳基氯化物，芳基溴化物，酯，羧酸和氰基的良好选择性。 不幸的是，使用该方法无法还原烷基硝基化合物，仅获得了单和二烷基化胺的混合物。

  DOI：

  10.1016/j.tet.2010.12.070
• 作为试剂：
  描述：

  4-(1-methyl-2-oxo-propylamino)-benzoic acid ethyl ester 在 4-氨基苯甲酸盐酸盐 作用下， 生成 2,3-二甲基-1H-吲哚-5-羧酸乙酯
  参考文献：
  名称：

  Verkade; Lieste, Recueil des Travaux Chimiques des Pays-Bas, 1946, vol. 65, p. 912,918

  摘要：

  DOI：

文献信息

• [EN] PHOTOALIGNING MATERIAL<br/>[FR] MATÉRIAU DE PHOTOALIGNEMENT
  申请人：ROLIC AG

  公开号：WO2013017467A1

  公开（公告）日：2013-02-07

  The present invention relates to a copolymer for the photoalignment of liquid crystals comprising a photoreactive group as given below in formula (I), compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).

  本发明涉及一种共聚物，用于液晶的光调向，包括如下所示的具有光反应性基团的化合物（I）的公式，以及其组合物，以及其在光学和电光设备，特别是液晶设备（LCD）中的使用。
• 一种阻燃剂双-(对-羧基苯氨基)苯基氧化膦 的合成方法
  申请人：湖北省兴发磷化工研究院有限公司

  公开号：CN109320551B

  公开（公告）日：2022-03-18

  本发明涉及到一种阻燃剂双‑（对‑羧基苯氨基）苯基氧化膦的改进合成方法。该方法包括下述步骤：将对氨基苯甲酸溶解于1,4‑二氧六环溶剂中，搅拌，缓慢滴加苯基磷酰二氯的1,4‑二氧六环溶液，滴加完后升温至40~60℃反应6~16小时，冷却过滤，固体依次用稀盐酸溶液和纯水搅拌洗涤、过滤，真空干燥即得目标产品，产率为76~82%。
• PHOTOREACTIVE COMPOUNDS
  申请人：Lincker Frederic

  公开号：US20140192305A1

  公开（公告）日：2014-07-10

  The present invention relates to photoreactive compounds that are particularly useful in materials for the alignment of liquid crystals.

  本发明涉及光反应性化合物，特别适用于液晶对准材料的制作。
• High graphite N content in nitrogen-doped graphene as an efficient metal-free catalyst for reduction of nitroarenes in water
  作者：Fan Yang、Cheng Chi、Chunxia Wang、Ying Wang、Yongfeng Li

  DOI：10.1039/c6gc00222f

  日期：——

  High graphite N content in nitrogen-doped graphene is synthesized by a one-step hydrothermal reaction, which can catalyze the reduction of nitroarenes by using a small amount of NaBH4 in water with high yield.

  一步法水热反应合成了氮掺杂石墨烯中较高的石墨N含量，通过在水中少量使用NaBH 4可以高产率地催化硝基芳烃的还原。
• PHOTOALIGNING MATERIAL
  申请人：Eckert Jean-Francois

  公开号：US20130035446A1

  公开（公告）日：2013-02-07

  The present invention relates to polymer, homo- or copolymer or oligomer for the photoalignment of liquid crystals comprising a main chain and a side chain, wherein the side chain comprises a difluoromethylene group, compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).

  本发明涉及用于液晶光调向的聚合物、同聚物或寡聚物，包括主链和侧链，其中侧链包括二氟甲亚甲基基团，以及其组合物，以及其在光学和电光设备，特别是液晶设备（LCD）中的应用。