(E)-1-(4-hydroxy-3-methoxyphenyl)undec-4-en-3-one | 99742-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-1-(4-hydroxy-3-methoxyphenyl)undec-4-en-3-one
• 英文别名: 1-(4-hydroxy-3-methoxy-phenyl)-undec-4-en-3-one；1-(4-Hydroxy-3-methoxy-phenyl)-undec-4-en-3-on
• CAS: 99742-07-1
• 化学式: C₁₈H₂₆O₃
• 分子量: 290.403
• InChiKey: GHBAGMWSYWCUGX-CMDGGOBGSA-N

物化性质

• 沸点：
  439.9±35.0 °C(Predicted)
• 密度：
  1.022±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  姜酮 在 4-甲基苯磺酸吡啶 、 对甲苯磺酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 苯 为溶剂， 反应 2.0h， 生成 (E)-1-(4-hydroxy-3-methoxyphenyl)undec-4-en-3-one
  参考文献：
  名称：

  Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult

  摘要：

  Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.041

文献信息

• Nomura; Tsurumi, Proceedings of the Imperial Academy (Tokyo), vol. 2, p. 231
  作者：Nomura、Tsurumi

  DOI：——

  日期：——
• Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult
  作者：Darrick S.H.L Kim、Jin Yung Kim

  DOI：10.1016/j.bmcl.2003.12.041

  日期：2004.3

  Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase. (C) 2003 Elsevier Ltd. All rights reserved.