2-thioanisyldichlorophosphine | 253686-37-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-thioanisyldichlorophosphine
• 英文别名: Dichloro-(2-methylsulfanylphenyl)phosphane
• CAS: 253686-37-2
• 化学式: C₇H₇Cl₂PS
• 分子量: 225.078
• InChiKey: RTQVEQLURZZWRP-UHFFFAOYSA-N

物化性质

• 沸点：
  281.1±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-thioanisyldichlorophosphine 以 乙醚 、 正己烷 、 甲苯 为溶剂， 反应 72.0h， 生成 (3aR,7aR)-1,3-dimethyl-2-o-methylthiophenyl-2,3,3a,4,5,6,7,7a-octahydro-1H-1,3,2-benzodiazaphosphole
  参考文献：
  名称：

  一系列单重氮和双重氮磷吡啶配体的合成及其在不对称催化中的应用

  摘要：

  一系列紧密相关的单和双（二氮杂磷腈）的合成 配体 通过使用 二胺与双（二甲基氨基）芳基膦。所结果的配体 取得了优异的成绩 钯-催化的烯丙基取代反应，形成C–C键（高达ee的89％）和C–N键（高达ee的78％）。

  DOI：

  10.1039/b106399p
• 作为产物：
  描述：

  2-溴茴香硫醚 在 正丁基锂 、 zinc(II) chloride 、 三氯化磷 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 1.0h， 生成 2-thioanisyldichlorophosphine
  参考文献：
  名称：

  一系列单重氮和双重氮磷吡啶配体的合成及其在不对称催化中的应用

  摘要：

  一系列紧密相关的单和双（二氮杂磷腈）的合成 配体 通过使用 二胺与双（二甲基氨基）芳基膦。所结果的配体 取得了优异的成绩 钯-催化的烯丙基取代反应，形成C–C键（高达ee的89％）和C–N键（高达ee的78％）。

  DOI：

  10.1039/b106399p

文献信息

• 2-Thioanisyldichlorophosphine, new starting material for the preparation of multidentate phosphine ligands: syntheses and characterization of derivatives of 2-anisyl- and 2-thioanisyldichlorophosphines
  作者：Riitta H. Laitinen、Ville Heikkinen、Matti Haukka、Ari M.P. Koskinen、Jouni Pursiainen

  DOI：10.1016/s0022-328x(99)00711-1

  日期：2000.4

  A new aryldichlorophosphine, 2-thioanisyldichlorophosphine, and its anisyl analogue, 2-anisyldichlorophosphine, were prepared by using an organozinc halide reagent of 2-thioanisole or 2-anisole with ethereal solution of PCl3 in refluxing conditions. From these aryldichlorophosphines, eight new multidentate phosphine ligands containing 2-thioanisyl, 4-thioanisyl, 2-anisyl, 1-naphthyl and 9-anthracenyl groups were synthesized and characterized. Characterization was based mainly on NMR spectroscopy and X-ray crystallography. The crystal structures of six ligands are reported. The electronic effects on basicity of ligands are discussed. (C) 2000 Elsevier Science S.A. All rights reserved.
• [EN] HYDROFORMYLATION PROCESS<br/>[FR] PROCEDE D'HYDROFORMYLATION
  申请人：NESTE CHEMICALS OY

  公开号：WO2000002890A1

  公开（公告）日：2000-01-20

  The present invention concerns a process for preparing substituted arylhalophosphines and derivatives thereof. According to the invention a substituted haloaryl is lithiated to form a substituted lithiumaryl which is subjected to metal exchange to provide a metal exchanged organometal compound. After reaction with a halophosphine compound a substituted aryl halophosphine is obtained. The present invention also provides a novel process for hydroformylation of olefinic compounds. The hydroformylation is carried out in the presence of a catalyst system based on a rhodium precursor and heterodonor ligands of the formula (I): YX1X2X3, wherein Y is phosphorus or arsenic and X1, X2 and X3 are each independently selected from aromatic groups comprising substituted phenyl and pyridyl groups, the substituents being hydrocarbyl groups attached to the aromatic ring at ortho-position via a heteroatom. With the various ligands of the present invention, i/n-ratios in range of 5 to 30 are obtainable. In the case of hydroformylation of methyl methacrylate, the selectivity of the methyl α-formylisobutyrate is 80 - 90 % and the amount of byproducts, such as methyl isobutyrate, is small.