N-butyl-N-methyl-(pyridin-3-yl)amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-butyl-N-methyl-(pyridin-3-yl)amine
• 英文别名: N-3-pyridyl-N-methyl-n-butylamine；N-butyl-N-methylpyridin-3-amine；N-methyl-3-pyridine butanamine
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: IMHOPBFSMNLAPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-溴吡啶 、 甲基丁胺 在 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 22.0h， 生成 N-butyl-N-methyl-(pyridin-3-yl)amine
  参考文献：
  名称：

  Efficient catalytic aryl amination of bromoarenes using 3-iminophosphine palladium(II) chloride

  摘要：

  While pursuing the development of new hydroamination catalysts, a 3-iminophosphine palladium(II) chloride complex [(3IP)PdCl2] was synthesized that has subsequently proven to be an effective precatalyst for the aryl amination of bromoarenes. This (3IP)PdCl2 complex has been utilized in the catalytic aryl amination of both bromobenzene and bromopyridine derivatives, specifically yielding excellent activity in coupling reactions involving bromobenzene, 4-bromotoluene, and 2-bromopyridine. Using a standard set of catalytic conditions, many alkyl and aryl amines have been investigated as coupling partners in the aryl amination of bromoarenes. In general, secondary alkyl amines and ortho-substituted anilines proved to be the best substrates for this reaction, commonly giving quantitative conversion to products, while primary amines and other anilines gave only poor to moderate results. Catalytic screening data, product yields, and full characterization of isolated products are included. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.08.027

文献信息

• Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite
  作者：Jia Hao Pang、Atsushi Kaga、Shunsuke Chiba

  DOI：10.1039/c8cc05979a

  日期：——

  A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

  在碘化锂（LiI）存在下，使用氢化钠（NaH）开发了甲氧基吡啶及其衍生物亲核胺化的新方案。该方法提供了对可能具有医学意义的各种氨基吡啶的简洁途径。
• An Efficient Silane-Promoted Nickel-Catalyzed Amination of Aryl and Heteroaryl Chlorides
  作者：Georg Manolikakes、Andrei Gavryushin、Paul Knochel

  DOI：10.1021/jo702219f

  日期：2008.2.1

  A new silane-promoted nickel-catalyzed amination of aryl chlorides with 0.5 mol % of Ni(acac)2, 1 mol% of 3,5,6,8-tetrabromo-1, 10-phenanthroline, and polymethythydrosiloxane was developed. A broad range of aryl and heteroaryl chlorides can be coupled with secondary amines and anilines to give the desired (het)arylamines in good to excellent yields. The reaction is sensitive to the nature and amount of the silane promoter.
• Pyrido(2,1-b)chinazolinderivate
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0094080B1

  公开（公告）日：1987-09-09