1-Benzyl-4-N,N-diethylaminomethyl-pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Benzyl-4-N,N-diethylaminomethyl-pyrrolidin-2-one
• 英文别名: 1-Benzyl-4-diethylaminomethyl-pyrrolidin-2-one；1-benzyl-4-(diethylaminomethyl)pyrrolidin-2-one
• 化学式: C₁₆H₂₄N₂O
• 分子量: 260.379
• InChiKey: ZHUVCTXJJNLPAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3'-二硝基联苯基-2,4'-二醇 、 乙醛 在 盐酸 作用下， 以 水 为溶剂， 生成 1-Benzyl-4-N,N-diethylaminomethyl-pyrrolidin-2-one
  参考文献：
  名称：

  Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants

  摘要：

  这项发明涉及将1-苄基-氨基烷基-吡咯烷酮用作抗抑郁药。

  公开号：

  US04812453A1

文献信息

• N-heterocyclic substituted -pyrrolidin-2-ones
  申请人：Boehringer Ingelheim KG

  公开号：US05149808A1

  公开（公告）日：1992-09-22

  Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di-substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; and R.sub.3 and R.sub.4 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; or R.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form an unsubstituted or methyl-substituted, saturated 5- or 6-membered heterocycle which may contain an additional oxygen or nitrogen heteroatom, or form an imidazole ring; where the aminomethyl substituent is attached to the 4- or 5-position or the pyrrolidine ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as nootropics and antihypoxics.

  化合物的公式为##STR1##其中R.sub.1是氢或1至4个碳原子的烷基；R.sub.2是2-、3-或4-吡啶基、苯基或单取代或双取代苯基，其中取代基分别为1至2个碳原子的烷氧基、氟、氯、溴、三氟甲基、1至4个碳原子的烷基、羟基或硝基；R.sub.3和R.sub.4各自独立地是氢或1至4个碳原子的烷基；或R.sub.3和R.sub.4与它们附着的氮原子一起形成一个未取代或甲基取代的饱和5-或6-成员杂环，该杂环可能包含一个额外的氧或氮杂原子，或形成咪唑环；其中氨甲基取代基附着于4-或5-位置或吡咯烷环上，以及其非毒性、药理学上可接受的酸盐。这些化合物及其盐可用作智力增强药和抗缺氧药。
• Piperazinyl and morpholinyl substituted 1-(benzyl or
  申请人：Boehringer Ingelheim KG

  公开号：US04767759A1

  公开（公告）日：1988-08-30

  Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di- substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; and R.sub.3 and R.sub.4 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; or R.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form an unsubstituted or methyl-substituted, saturated 5- or 6-membered heterocycle which may contain an additional oxygen or nitrogen heteroatom, or form an imidazole ring; where the aminomethyl substituent is attached to the 4- or 5-position or the pyrrolidine ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as nootropics and antihypoxics.

  化合物的化学式为##STR1##其中R.sub.1是氢或1至4个碳原子的烷基; R.sub.2是2-、3-或4-吡啶基、苯基或单取代或双取代苯基，其中取代基分别为1至2个碳原子的烷氧基、氟、氯、溴、三氟甲基、1至4个碳原子的烷基、羟基或硝基; R.sub.3和R.sub.4各自独立地是氢或1至4个碳原子的烷基; 或者R.sub.3和R.sub.4连同它们所附着的氮原子一起，形成一个未取代或甲基取代的饱和5-或6-成员杂环，该杂环可能含有额外的氧或氮杂原子，或形成咪唑环; 其中氨甲基取代基附着于4-或5-位置或吡咯烷环，以及其无毒、药理学上可接受的酸盐。这些化合物及其盐在智力增强和抗缺氧方面有用。
• 1-(benzyl or pyridylmethyl)-4 or 5-aminomethyl-pyrrolidin-2-ones
  申请人：Boehringer Ingelheim KG

  公开号：US04833140A1

  公开（公告）日：1989-05-23

  Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or disubstituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; and R.sub.3 and R.sub.4 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; or R.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form an unsubstituted or methyl-substituted, saturated 5- or 6-membered heterocycle which may contain an additional oxygen or nitrogen heteroatom, or form an imidazole ring; where the aminomethyl substituent is attached to the 4- or 5-position or the pyrrolidine ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as nootropics and antihypoxics.

  化合物的结构式为## STR1 ##，其中R.sub.1是氢或1至4个碳原子的烷基; R.sub.2是2-，3-或4-吡啶基，苯基或单取代或双取代苯基，其中取代基分别是1至2个碳原子的烷氧基，氟，氯，溴，三氟甲基，1至4个碳原子的烷基，羟基或硝基; R.sub.3和R.sub.4各自独立地是氢或1至4个碳原子的烷基; 或者R.sub.3和R.sub.4与它们附着的氮原子一起形成未取代或取代甲基的饱和5-或6-成员杂环，该杂环可以包含额外的氧或氮杂原子，或形成咪唑环; 其中氨甲基取代基附着于4-或5-位置或吡咯烷环，以及其非毒性、药理学上可接受的酸盐。这些化合物以及盐对于改善认知和抗缺氧作用有用。
• Verwendung von 1-Benzyl-amino-alkyl-pyrrolidinonen als Antidepressiva
  申请人：BOEHRINGER INGELHEIM KG

  公开号：EP0266563A2

  公开（公告）日：1988-05-11

  Die Erfindung betrifft die Verwendung von 1-Benzyl-aminoalkyl-pyrrolidinonen als Antidepressiva.

  本发明涉及 1-苄基-氨基烷基吡咯烷酮作为抗抑郁剂的用途。
• 1-Benzyl-aminoalkyl-pyrrolidinone und ihre Säureadditionssalze, Verfahren zu ihrer Herstellung und Arzneimittel
  申请人：BOEHRINGER INGELHEIM KG

  公开号：EP0136658B1

  公开（公告）日：1989-04-26