N-(2,2-diethoxyethyl)-2-phenylacetamide | 722479-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,2-diethoxyethyl)-2-phenylacetamide
• 英文别名: phenyl-acetic acid-(2,2-diethoxy-ethylamide)；Phenyl-essigsaeure-(2,2-diaethoxy-aethylamid)
• CAS: 722479-69-8
• 化学式: C₁₄H₂₁NO₃
• mdl: MFCD27666317
• 分子量: 251.326
• InChiKey: UCXFKPKVZQCZQV-UHFFFAOYSA-N

物化性质

• 熔点：
  37 °C
• 沸点：
  419.6±45.0 °C(Predicted)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2,2-diethoxyethyl)-2-phenylacetamide 在 盐酸 作用下， 以 乙醚 、 苯 为溶剂， 反应 28.0h， 生成 N-(2-氧乙基)-2-苯基乙酰胺
  参考文献：
  名称：

  Design, synthesis, and evaluation of α-ketoheterocycles as class C β-lactamase inhibitors

  摘要：

  A series of specific alpha -ketoheterocycles (benzoxazole, thiazole, imidazole, tetrazole, and thiazole-4-carboxylate) has been synthesized in order to assess their potential as beta -lactamase inhibitors. The syntheses were achieved either by construction of the heterocycle (benzoxazole) from an appropriate alpha -hydroxyimidate, followed by oxidation of the alcohol, or by direct reaction of methyl phenaceturate with a lithiated heterocycle. The properties of these compounds in aqueous solution are described and their inhibitory activity against beta -lactamases assessed. They did inhibit the class C beta -lactamase of Enterobacter cloacae P99 but not the TEM beta -lactamase. The most effective inhibitor of the former enzyme (K-i = 0.11 mM) was 5-(phenylacetylglycyl) tetrazole, probably because it is an anion at neutral pH, Interpretation of the results was aided by computational models of the tetrahedral adducts. Most of the compounds also inhibited a-chymotrypsin but not porcine pancreatic elastase. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00107-9
• 作为产物：
  描述：

  2-苯乙酰胺 在 氢化钾 、 xylene 作用下， 生成 N-(2,2-diethoxyethyl)-2-phenylacetamide
  参考文献：
  名称：

  Brown, Chemistry of Penicillin

  摘要：

  DOI：

文献信息

• Iodide-umpolung catalytic system for non-traditional amide coupling from nitroalkanes and amines
  作者：Chun-Lin Chen、Tian-Sih Huang、Po-Hsiang Chang、Che-Sheng Hsu

  DOI：10.1039/d4ob00184b

  日期：——

  from nitroalkanes and amines. In contrast to traditional oxidative catalysis, this catalytic system involves reversing the polarities of two catalytic components (umpolung) by means of a hypervalent iodine reagent. A variety of functional groups were tolerated in the reaction, suggesting that they have the potential for use in other types of oxidative catalytic reactions.

  开发了一种N-碘代琥珀酰亚胺 (NIS) 催化剂，用于以硝基烷烃和胺为原料非传统合成酰胺衍生物。与传统的氧化催化相反，该催化系统涉及通过高价碘试剂反转两种催化组分的极性（umpolung）。该反应中可以耐受多种官能团，这表明它们具有用于其他类型氧化催化反应的潜力。
• Mozingo; Folkers, Chemistry of Penicillin
  作者：Mozingo、Folkers

  DOI：——

  日期：——
• Cook, Chemistry of Penicillin
  作者：Cook

  DOI：——

  日期：——
• CRYSTALLINE PHENYLISOCYANATE DERIVATIVES FROM BENZYLPENICILLOIC ACID AND α-METHYL BENZYLPENICILLOATE
  作者：SELBY B. DAVIS、STUART D. WILLSON、R. BRUCE VAN ORDER

  DOI：10.1021/jo01163a011

  日期：1948.9