(4-methoxy-phenyl)-[4-(3,4,5-tris-octadecyloxy-cyclohexylmethoxy)-phenyl]-methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-methoxy-phenyl)-[4-(3,4,5-tris-octadecyloxy-cyclohexylmethoxy)-phenyl]-methanol
• 英文别名: (4-methoxyphenyl)-[4-[(3,4,5-trioctadecoxycyclohexyl)methoxy]phenyl]methanol
• 化学式: C₇₅H₁₃₄O₆
• 分子量: 1131.89
• InChiKey: JYUUKUXILOBOLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  29.7
• 重原子数：
  81
• 可旋转键数：
  60
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4-methoxy-phenyl)-[4-(3,4,5-tris-octadecyloxy-cyclohexylmethoxy)-phenyl]-methanol 在 甲烷磺酸 、 乙醇 、 sodium hydroxide 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 {(4-methoxy-phenyl)-[4-(3,4,5-tris-octadecyloxy-cyclohexylmethoxy)-phenyl]-methyl}-amine
  参考文献：
  名称：

  EP2415745

  摘要：

  公开号：
• 作为产物：
  描述：

  3,4,5-tris(octadecyloxy)cyclohexylmethyl alcohol 在 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 (4-methoxy-phenyl)-[4-(3,4,5-tris-octadecyloxy-cyclohexylmethoxy)-phenyl]-methanol
  参考文献：
  名称：

  EP2415745

  摘要：

  公开号：

文献信息

• DIPHENYLMETHANE COMPOUND
  申请人：TAKAHASHI Daisuke

  公开号：US20100249374A1

  公开（公告）日：2010-09-30

  Compounds having a diphenylmethane skeleton are superior in broad utility and stability, and are useful as a protecting reagent (anchor) of amino acid and/or peptide in the liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide(-CONHR)-type, and in organic synthetic reaction methods (particularly peptide liquid phase synthetic methods), and may be contained in a kit for peptide liquid phase synthesis.

  具有二苯甲烷骨架的化合物在广泛的用途和稳定性方面表现优越，可用作液相合成中氨基酸和/或肽的保护试剂（锚点），例如具有C-末端等的肽的合成，其为羧酰胺（-CONHR）类型，并且在有机合成反应方法（特别是肽液相合成方法）中有用，可包含在用于肽液相合成的试剂盒中。
• METHOD FOR REMOVING FMOC GROUP
  申请人：Ajinomoto Co., Inc.

  公开号：US20140296483A1

  公开（公告）日：2014-10-02

  The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I): HS-L-COOH  (I) wherein L is a C 1-8 alkylene group optionally having substituent(s), an amino group-containing compound protected by an Fmoc group, and a base to give a reaction mixture containing a compound represented by the formula (II): Fm-S-L-COOH  (II) wherein Fm is a 9-fluorenylmethyl group, and L is as mentioned above, and an amino group-containing compound, and a step of removing the compound represented by the formula (II) by washing the obtained reaction mixture with a basic aqueous solution. According to the present invention, a removal method of Fmoc group, which can remove a dibenzofulvene derivative as a byproduct with ease, can be provided.

  本发明涉及一种去除Fmoc基团的方法，包括混合式化合物（I）的步骤：HS-L-COOH（I），其中L是一个C1-8烷基链，可选地具有取代基，一种被Fmoc基团保护的氨基化合物和一种碱，以得到一种反应混合物，其中包含一种化合物，其由式（II）表示：Fm-S-L-COOH（II），其中Fm是9-芴甲基基团，L如上所述，还包括一种氨基化合物，以及通过用碱性水溶液洗涤所得到的反应混合物，去除由式（II）表示的化合物。根据本发明，可以提供一种可以轻松去除二苯并富烯衍生物作为副产物的Fmoc基团去除方法。
• Diphenylmethane compound
  申请人：Takahashi Daisuke

  公开号：US08722934B2

  公开（公告）日：2014-05-13

  Compounds having a diphenylmethane skeleton are superior in broad utility and stability, and are useful as a protecting reagent (anchor) of amino acid and/or peptide in the liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide(-CONHR)-type, and in organic synthetic reaction methods (particularly peptide liquid phase synthetic methods), and may be contained in a kit for peptide liquid phase synthesis.

  具有二苯甲烷骨架的化合物在广泛的实用性和稳定性方面优于其他化合物，并且可用作氨基酸和/或肽的保护试剂（锚）在液相合成中的C-末端等具有羧酰胺（-CONHR）类型的肽以及有机合成反应方法（特别是肽液相合成方法）中使用，并且可以包含在肽液相合成试剂盒中。
• Method of making peptides using diphenylmethane compound
  申请人：AJINOMOTO CO., INC.

  公开号：US09169187B2

  公开（公告）日：2015-10-27

  The present invention aims to provide a compound superior in broad utility and stability, which is useful as a protecting reagent (anchor) of amino acid and/or peptide in liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide (—CONHR)-type, an organic synthesis reaction method (particularly peptide liquid phase synthesis method) using the compound, and a kit for peptide liquid phase synthesis containing the compound, and has found that the object can be achieved by a particular compound having a diphenylmethane skeleton.

  本发明旨在提供一种具有广泛实用性和稳定性的化合物，该化合物可用作肽液相合成等具有C-末端的羧酰胺（—CONHR）类型的氨基酸和/或肽的保护试剂（锚点），以及使用该化合物的有机合成反应方法（特别是肽液相合成方法）和包含该化合物的肽液相合成试剂盒。本发明发现，通过具有二苯甲烷骨架的特定化合物可以实现该目的。
• BLOCK-COPOLYMER HYDRIDE HAVING ACID ANHYDRIDE GROUP AND USE THEREOF
  申请人：Zeon Corporation

  公开号：EP3412689A1

  公开（公告）日：2018-12-12

  The present invention pertains to a laminated glass obtained by: interposing, between glass plates, a resin sheet comprising a resin composition obtained by blending 100 parts by weight of a specific modified hydrogenated block-copolymer having an introduced acid anhydride group, and a total of 0.001 to 2.0 parts by weight of a near infrared ray-absorbing pigment and/or a metal oxide particulate having a function of shielding infrared ray, to obtain a laminate; and integrally bonding the laminate including the glass plates and the resin sheet. The aspects of the invention provide a novel hydrogenated block copolymer having an acid anhydride group; a resin composition that includes the hydrogenated block copolymer, has excellent heat insulating function, and is suitable as a laminated glass intermediate film-forming material excellent in moisture resistance and durability; a resin sheet made of the resin composition; and a laminated glass in which the resin sheet is interposed between glass plates through an adhesive and the laminate including the glass plates and the resin sheet is adhesively integrated.

  本发明涉及一种夹层玻璃，其制备方法是：在玻璃板之间夹入一种树脂薄片，该树脂薄片包含一种树脂组合物，该树脂组合物是通过混合100份（重量）具有引入酸酐基团的特定改性氢化嵌段共聚物和总计0.001至2.0份（重量）具有屏蔽红外线功能的近红外射线吸收颜料和/或金属氧化物微粒而获得的一种层压板；以及整体粘合包括玻璃板和树脂薄片在内的层压板。本发明的各个方面提供了一种具有酸酐基团的新型氢化嵌段共聚物；一种包括该氢化嵌段共聚物的树脂组合物，该树脂组合物具有优异的隔热功能，并且适合用作防潮性和耐久性优异的夹层玻璃中间成膜材料；一种由该树脂组合物制成的树脂片；以及一种夹层玻璃，其中该树脂片通过粘合剂夹在玻璃板之间，并且包括玻璃板和树脂片的层压板被粘合为一体。