bis(ethoxycarbonyl) disulphide | 6365-90-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 英文名称: bis(ethoxycarbonyl) disulphide
• 英文别名: bis(ethoxycarbonyl)disulfane；bis-ethoxycarbonyl-disulfane；Bis-aethoxycarbonyl-disulfan；'Aethylformiatdisulfid'；O-Aethyl-kohlensaeure-persulfid；Dicarbaethoxy-disulfid；Bis-carbethoxy-disulphide；ethyl (ethoxycarbonyldisulfanyl)formate
• CAS: 6365-90-8
• 化学式: C₆H₁₀O₄S₂
• 分子量: 210.275
• InChiKey: RSBGPXXZTFSQAA-UHFFFAOYSA-N

物化性质

• 沸点：
  108 °C(Press: 2 Torr)
• 密度：
  1.265 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  bis(ethoxycarbonyl) disulphide 生成 碳酸二乙酯
  参考文献：
  名称：

  Twiss, Journal of the American Chemical Society, 1927, vol. 49, p. 493

  摘要：

  DOI：
• 作为产物：
  描述：

  ethoxy(potassiosulfanyl)methanethione 在 碘 作用下， 以 氯仿 、 水 为溶剂， 生成 bis(ethoxycarbonyl) disulphide
  参考文献：
  名称：

  A general strategy for elaboration of the dithiocarbonyl functionality, -(C:O)SS-: application to the synthesis of bis(chlorocarbonyl)disulfane and related derivatives of thiocarbonic acids

  摘要：

  DOI：

  10.1021/jo00172a056

文献信息

• [EN] BIOREVERSABLE PROMOIETIES FOR NITROGEN-CONTAINING AND HYDROXYL-CONTAINING DRUGS<br/>[FR] PRO-FRAGMENTS BIORÉVERSIBLES POUR MÉDICAMENTS CONTENANT DE L'AZOTE ET DE L'HYDROXYLE
  申请人：BAIKANG SUZHOU CO LTD

  公开号：WO2015081891A1

  公开（公告）日：2015-06-11

  Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent: (I) and pharmaceutical compositions comprising the prodrugs.

  披露了以下公式的促销性质，它们可用于形成含有氮或羟基的药物或药物活性剂的的前药：(I)以及包含这些前药的药物组合物。
• Oligomer Extended Insulin-FC Conjugates
  申请人：Novo Nordisk A/S

  公开号：US20200261595A1

  公开（公告）日：2020-08-20

  This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.

  这项发明属于蛋白共轭物领域。更具体地，该发明涉及具有共价连接的Fc单体多肽的寡聚体延伸胰岛素，用于治疗代谢紊乱或疾病，并涉及制备这种寡聚体延伸胰岛素-Fc共轭物的方法。该发明还涉及新颖的Fc片段，中间产物，以及在合成该发明的寡聚体延伸胰岛素-Fc共轭物的过程中使用这种中间产物。最后，该发明提供了包括该发明的寡聚体延伸胰岛素-Fc共轭物的药物组合物，并涉及使用这种组合物治疗或预防与代谢紊乱或疾病相关的医疗状况。
• Insertion of α-Phosphorylcarbene Moiety into S-S and Se-Se Bonds: Synthesis of Dithio- and Diselenoacetals of Formylphosphonates
  作者：M. Mikołajczyk、M. Mikina、P. P. Graczyk、P. Bałczewski

  DOI：10.1055/s-1996-4355

  日期：1996.10

  Reaction between diazomethanephosphonates and disulfides or diselenides catalyzed by boron trifluoride - diethyl ether complex leads to insertion of the (RO)2P(O)-CH(:) moiety into S-S and Se-Se bonds, respectively. The proposed method makes it possible to synthesize 2-phosphoryl-substituted 1,3-diselenanes, not available by other means. The yield depends on the reaction conditions. Stereoselectivity of insertion into cyclic systems is discussed. Reactions catalyzed by rhodium(II) acetate or anhydrous copper(II) sulfate afford the relevant sulfides, (RO)2P(O)-CH2SR. The possible ionic and free radical mechanistic pathways are presented.

  二氟肥基磷酸酯与二硫化物或二硒化物在三氟化硼-二乙醚复合物催化下发生反应，导致 (RO)2P(O)-CH(:) 基团插入 S-S 和 Se-Se 键。所提出的方法使得能够合成其他方法无法获得的 2-磷酸基取代的 1,3-二硒烷。产率取决于反应条件。还讨论了在环状体系中插入的立体选择性。由二价铑乙 acetate 或无水二价铜硫酸盐催化的反应产生相关的硫化物 (RO)2P(O)-CH2SR。提出了可能的离子和自由基机制途径。
• Stereoselective Synthesis of (<i>E</i>)- or (<i>Z</i>)-α-Alkylidene-γ-butyrolactone from γ-Butyrolactone and Bis[ethoxy(thiocarbonyl)] Disulfide and Mechanistic Studies of the Effect of Metal Complexes on the Stereoselection
  作者：Syuichi Matsui

  DOI：10.1246/bcsj.60.1853

  日期：1987.5

  with an aldehyde to afford exclusively (E)-α-alkylidene-γ-butyrolactone. Interestingly, when the reaction was quenched below −20 °C or when it was carried out in the presence of metal complex such as zinc chloride, copper(I) iodide, or tributyltin chloride, (Z)-α-alkylidene-γ-butyrolactone was obtained as the major product. The stereoselectivity of this reaction was sensitive to the reaction temperature

  在 2.2 当量二异丙基氨基锂 (LDA) 存在下，用双 [乙氧基（硫代羰基）] 二硫化物处理 γ-丁内酯，生成 O-乙基 S-（四氢-2-氧代-3-呋喃基）二硫代碳酸酯的烯醇锂，其反应用醛生成仅 (E)-α-亚烷基-γ-丁内酯。有趣的是，当反应在 -20 °C 以下猝灭或在金属络合物（如氯化锌、碘化铜（I）或氯化三丁基锡、（Z）-α-亚烷基-γ-丁内酯）存在下进行时作为主要产品获得。该反应的立体选择性对反应温度和所用金属阳离子敏感。
• INSULIN ALBUMIN CONJUGATES
  申请人：Tagmose Tina Møller

  公开号：US20110039769A1

  公开（公告）日：2011-02-17

  Insulin albumin conjugates consisting of an insulin analogue, a bifunctional linker and albumin can efficiently be used to treat diabetic patients.

  胰岛素白蛋白偶联物由胰岛素类似物、双功能连接剂和白蛋白组成，可有效用于治疗糖尿病患者。