diphenyl (4'-aminobiphenyl-4-ylamino)(pyridin-3-yl)methylphosphonate | 1392848-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenyl (4'-aminobiphenyl-4-ylamino)(pyridin-3-yl)methylphosphonate
• CAS: 1392848-70-2
• 化学式: C₃₀H₂₆N₃O₃P
• 分子量: 507.529
• InChiKey: JWYYMMFQDAKUOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.79
• 重原子数：
  37.0
• 可旋转键数：
  9.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  86.47
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  diphenyl (4'-aminobiphenyl-4-ylamino)(pyridin-3-yl)methylphosphonate 、 对氨基苯酚 在 盐酸 、 sodium nitrite 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.5h， 以84%的产率得到diphenyl (4'-((5-amino-2-hydroxyphenyl)diazenyl)biphenyl-4-ylamino)(pyridin-3-yl)methylphosphonate
  参考文献：
  名称：

  Antimicrobial Activities of a Series of Diphenyl (4′-(Aryldiazenyl)Biphenyl-4-Ylamino)(Pyridin-3-YL)Methylphosphonates

  摘要：

  A series of diphenyl (4'-(aryldiazenyl)biphenyl-4-ylamino)(pyridin-3-yl)methylphosphonates 2-7 was synthesized in high yields and their antimicrobial activities were investigated. Some compounds showed high antimicrobial activities against Escherichia coli as a gram-negative bacterium, Bacillus subtilis and Staphylococcus aureus as gram-positive bacteria, and Candida albicans and Schccaromycies cerevisiae as fungi and at low concentrations (10-1000 mu g/mL). Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426507.2012.680084
• 作为产物：
  描述：

  3-吡啶甲醛 、 亚磷酸三苯酯 、 联苯胺 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 26.0h， 以88%的产率得到diphenyl (4'-aminobiphenyl-4-ylamino)(pyridin-3-yl)methylphosphonate
  参考文献：
  名称：

  Antimicrobial Activities of a Series of Diphenyl (4′-(Aryldiazenyl)Biphenyl-4-Ylamino)(Pyridin-3-YL)Methylphosphonates

  摘要：

  A series of diphenyl (4'-(aryldiazenyl)biphenyl-4-ylamino)(pyridin-3-yl)methylphosphonates 2-7 was synthesized in high yields and their antimicrobial activities were investigated. Some compounds showed high antimicrobial activities against Escherichia coli as a gram-negative bacterium, Bacillus subtilis and Staphylococcus aureus as gram-positive bacteria, and Candida albicans and Schccaromycies cerevisiae as fungi and at low concentrations (10-1000 mu g/mL). Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426507.2012.680084