phenyl chlorosulphinate | 13165-73-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl chlorosulphinate
• 英文别名: phenyl chlorosulfinate；phenyl chlorosulfite；chlorosulfurous acid phenyl ester；Schwefligsaeure-phenylester-chlorid；Chloroschwefligsaeure-phenylester；Phenyl-chlorosulfit；Chlorosulfinyloxy-benzene；chlorosulfinyloxybenzene
• CAS: 13165-73-6
• 化学式: C₆H₅ClO₂S
• 分子量: 176.624
• InChiKey: MCIYNZNEOWHWNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl chlorosulphinate 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 生成 三苯基硼酸酯
  参考文献：
  名称：

  Notes

  摘要：

  DOI：

  10.1039/jr9620001505
• 作为产物：
  描述：

  diphenyl sulfite 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 生成 phenyl chlorosulphinate
  参考文献：
  名称：

  Notes

  摘要：

  DOI：

  10.1039/jr9620001505

文献信息

• Organic Sulfur Compounds. V. Reactions of Arylsulfonic Acids with Alkyl and Aryl Chlorosulfites
  作者：Asami Yamamoto、Michio Kobayashi

  DOI：10.1246/bcsj.39.1288

  日期：1966.6

  p-toluenesulfonate has been found to react with alkyl and aryl chlorosulfite to give p-toluenesulfonic esters. Mixed anhydrides of the sulfonic acid and monoalkyl or monoaryl sulfite were postulated as the intermediates. No rearrangement of the alkyl group was observed during the reaction. The reaction mechanism was studied by means of the 18O tracer technique.

  已发现对甲苯磺酸银与氯亚硫酸烷基酯和芳基酯反应生成对甲苯磺酸酯。磺酸和单烷基或单芳基亚硫酸盐的混合酸酐被假定为中间体。在反应过程中没有观察到烷基的重排。通过18O示踪技术研究了反应机理。
• Process for the preparation of phosphorothioate triesters
  申请人：——

  公开号：US20030099981A1

  公开（公告）日：2003-05-29

  A process for the synthesis of a phosphorothioate triester is provided. The process comprises the coupling of an H-phosphonate with an alcohol in the presence of a solution comprising both a coupling agent and a sulfur transfer agent. Preferably, the H-phosphorate and alcohol are protected nucleosides or oligonucleotides.

  提供一种合成磷酸硫酯三酯的过程。该过程包括在存在耦合剂和硫转移剂的溶液中，将H-膦酸酯与醇耦合。最好，H-膦酸酯和醇是受保护的核苷酸或寡核苷酸。
• Curing compositions
  申请人：Lingner + Fischer GmbH

  公开号：EP0079703A1

  公开（公告）日：1983-05-25

  A curing composition consisting of two components, one of the components comprising a vinyl monomer and an initiator of polymerisation, the other component comprising an accelerator of polymerisation, characterised in that the composition further comprises a redox indicator having Eo from above +0.01 to below +0.76 volts and RH from 13.5 to 28.

  一种由两种成分组成的固化组合物，其中一种成分包括乙烯基单体和聚合引发剂，另一种成分包括聚合促进剂，其特征在于该组合物还包括一种氧化还原指示剂，其 Eo 值在 +0.01 至 +0.76 伏特之间，相对湿度在 13.5 至 28 之间。
• Synthesis of oligonucleotides
  申请人：Avecia Limited

  公开号：EP1325927A2

  公开（公告）日：2003-07-09

  A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate diester is oxidised in situ with a sulfur transfer agent to produce the phosphorothioate triester. Preferably, the H-phosphonate and alcohol are protected nucleosides or oligonucleotides. Oligonucleotide H-phosphonates which can be used in the formation of phosphorothioate triesters are also provided.

  本发明提供了一种在溶液相中合成硫代磷酸酯三酯的工艺。该工艺包括在偶联剂存在下，将 H-膦酸盐与醇进行溶液相偶联，形成 H-膦酸盐二酯。H-phosphonate 二酯与硫转移剂原位氧化，生成硫代磷酸酯三酯。H-phosphonate 和醇最好是受保护的核苷或寡核苷酸。还提供了可用于形成硫代磷酸三酯的寡核苷酸 H-膦酸盐。
• Solution phase synthesis of oligonucleotides
  申请人：Avecia Limited

  公开号：US20030083490A1

  公开（公告）日：2003-05-01

  A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate diester is oxidised in situ with a sulfur transfer agent to produce the phosphorothioate triester. Preferably, the H-phosphonate and alcohol are protected nucleosides or oligonucleotides. Oligonucleotide H-phosphonates which can be used in the formation of phosphorothioate triesters are also provided.

  本发明提供了一种在溶液相中合成硫代磷酸酯三酯的工艺。该工艺包括在偶联剂存在下，将 H-膦酸盐与醇进行溶液相偶联，形成 H-膦酸盐二酯。H-phosphonate 二酯与硫转移剂原位氧化，生成硫代磷酸酯三酯。H-phosphonate 和醇最好是受保护的核苷或寡核苷酸。还提供了可用于形成硫代磷酸三酯的寡核苷酸 H-膦酸盐。