2-(2-Hydroxyethyl)-1-(2-sulfanylethyl)guanidine | 132607-10-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(2-Hydroxyethyl)-1-(2-sulfanylethyl)guanidine
• CAS: 132607-10-4
• 化学式: C₅H₁₃N₃OS
• 分子量: 163.244
• InChiKey: MYYNHGVCAWHWFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  71.6
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二硫化碳 、 2-(2-Hydroxyethyl)-1-(2-sulfanylethyl)guanidine 反应 12.0h， 生成 Trithiocarbonic acid mono-{2-[N'-(2-hydroxy-ethyl)-guanidino]-ethyl} ester
  参考文献：
  名称：

  脂肪族氨基醇对2-氨基-2-噻唑啉衍生物的溶剂化作用

  摘要：

  DOI：

  10.1023/a:1022190728686
• 作为产物：
  描述：

  β-Hydroxyethylthiourea 、 2-溴乙胺氢溴酸盐 以 异丙醇 为溶剂， 反应 1.0h， 生成 2-(2-Hydroxyethyl)-1-(2-sulfanylethyl)guanidine
  参考文献：
  名称：

  Synthesis of N-derivatives of guanidinoethanethiols and their antiradiation activity on the yeastSaccharomyces Cerevisiae

  摘要：

  DOI：

  10.1007/bf00766547

文献信息

• Neuroprotective effects of mercaptoethylleonurine and mercaptoethylguanidine analogs on hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells
  作者：Zhao-Lin Que、Wen-Jiang Zhou、Jun Chang、Xin-Hua Liu、Jian-Ming Yu、Xun Sun

  DOI：10.1016/j.bmcl.2013.01.038

  日期：2013.3

  A series of mercaptoethylleonurine and mercaptoethylguanidine derivatives were designed and synthesized. Their neuroprotective effects toward H2O2-induced apoptosis were investigated in human SH-SY5Y cells. The results from these studies identified several potent compounds, with compound 8k emerging as the most effective. Further investigation demonstrated that 8k reduced H2O2-induced activation of mitochondrial apoptosis by inhibiting the expression of Bax and elevating the expression of Bcl-2. Moreover, the molecular mechanism underlying the observed neuroprotective effects of 8k was exerted via the Akt and JNK pathways. Compound 8k can be a lead compound for further discovery of neuroprotective medicine. (C) 2013 Elsevier Ltd. All rights reserved.
• RODYUNIN, A. A.;ZOLOTAREVA, L. T.;MANDRUGIN, A. A.;FEDOSEEV, V. M., XIM.-FARMATS. ZH., 24,(1990) N0, S. 44-46
  作者：RODYUNIN, A. A.、ZOLOTAREVA, L. T.、MANDRUGIN, A. A.、FEDOSEEV, V. M.

  DOI：——

  日期：——
• ——
  作者：A. A. Mandrugin、V. M. Fedoseev、O. V. Dubovaya、A. A. Rodyunin、M. N. Semenko

  DOI：10.1023/a:1022190728686

  日期：——
• Synthesis of N-derivatives of guanidinoethanethiols and their antiradiation activity on the yeastSaccharomyces Cerevisiae
  作者：A. A. Rodyunin、L. T. Zolotareva、A. A. Mandrugin、V. M. Fedoseev

  DOI：10.1007/bf00766547

  日期：1990.10