(E)-3-chloro-N'-(2-hydroxybenzylidene)benzohydrazide | 116324-93-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-3-chloro-N'-(2-hydroxybenzylidene)benzohydrazide
• 英文别名: 3-chloro-benzoic acid salicylidenehydrazide；3-Chlor-benzoesaeure-salicylidenhydrazid；3-chloro-N'-(2-hydroxybenzylidene)benzohydrazide；3-chloro-N-[(E)-(2-hydroxyphenyl)methylideneamino]benzamide
• CAS: 116324-93-7
• 化学式: C₁₄H₁₁ClN₂O₂
• 分子量: 274.707
• InChiKey: VGFRGRIZCNPEQC-CXUHLZMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氯苯甲酸乙酯 在 乙醇 、 一水合肼 作用下， 生成 (E)-3-chloro-N'-(2-hydroxybenzylidene)benzohydrazide
  参考文献：
  名称：

  Sah; Wu, Science Reports of National Tsing Hua University, Series A: Mathematical, Physical, and Engineering Sciences, 1936, vol. 3, p. 443,446

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS<br/>[FR] ANALOGUES DE (E)-N'-(1-PHÉNYLÉTHYLIDÈNE)BENZOHYDRAZIDE SUBSTITUÉS EN TANT QU'INHIBITEURS DE L'HISTONE DÉMÉTHYLASE
  申请人：UNIV UTAH RES FOUND

  公开号：WO2013025805A1

  公开（公告）日：2013-02-21

  In one aspect, the invention relates to substituted (E)-N'-(1- phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及替代(E)-N'-(1-苯乙烯基)苯甲酰肼类似物，其衍生物以及相关化合物，这些化合物可用作赖氨酸特异性组蛋白去甲基化酶的抑制剂，包括LSD1；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与LSD1功能障碍相关的疾病的方法。本摘要旨在作为在特定领域进行搜索的扫描工具，并不旨在限制本发明。
• SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER
  申请人：Young David H.

  公开号：US20120010075A1

  公开（公告）日：2012-01-12

  The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.

  本发明涉及使用含有肼化合物和铜的混合物来控制真菌生长。
• SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS
  申请人：Vankayalapati Hariprasad

  公开号：US20140163017A1

  公开（公告）日：2014-06-12

  In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及取代的(E)-N′-(1-苯乙烯基)苯肼类似物、其衍生物和相关化合物，它们可用作赖氨酸特异性组蛋白去甲基化酶，包括LSD1的抑制剂；制备这些化合物的合成方法；含有这些化合物的制药组合物；以及使用这些化合物和组合物治疗与LSD1功能障碍相关的疾病的方法。本摘要旨在作为搜索特定技术领域的扫描工具，不旨在限制本发明。
• USE OF METAL HYDRAZIDE COMPLEX COMPOUNDS AS OXIDATION CATALYSTS
  申请人：BASF SE

  公开号：EP3524347A1

  公开（公告）日：2019-08-14

  The present invention relates to the use of selected metal complex compounds as oxidation catalysts as well as to a process for removing stains and soil on textiles and hard surfaces. The metal complex compounds have hydrazide ligands, preferably with electron withdrawing groups in the phenyl ring adjacent to the acyl group. Further aspects of the invention are formulations comprising such metal complex compounds, novel metal complex compounds and novel ligands.

  本发明涉及使用选定的金属络合物作为氧化催化剂，以及去除纺织品和硬表面污渍和污垢的工艺。金属络合物具有酰肼配体，最好是在邻近酰基的苯基环上具有取电子基团。本发明的其他方面是包含此类金属络合物、新型金属络合物和新型配体的制剂。
• Synthesis of new acylhydrazones as iron-chelating compounds
  作者：John T. Edward、Mario Gauthier、Francis L. Chubb、Premysl Ponka

  DOI：10.1021/je00054a044

  日期：1988.10