1,1-二乙氧基-3-苯基丙-1-烯 | 63473-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,1-二乙氧基-3-苯基丙-1-烯
• 英文名称: 1,1-diethoxy-3-phenylprop-1-ene
• 英文别名: benzyl-ketene-diethylacetal；Benzyl-keten-diaethylacetal；3,3-Diethoxyprop-2-enylbenzene
• CAS: 63473-79-0
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: MNRFKZHVSWWNAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯代丙腈 在 盐酸 、 aluminum tri-tert-butoxide 作用下， 生成 1,1-二乙氧基-3-苯基丙-1-烯
  参考文献：
  名称：

  Ketene Acetals. XXIX. The Mechanism of the Reaction of Ketene Acetal with Various Halides

  摘要：

  DOI：

  10.1021/ja01130a057

文献信息

• 2,2-Di(ethoxy)vinyllithium: A synthetic equivalent of the ethyl acetate anion
  作者：Heng-xu Wei、Manfred Schlosser

  DOI：10.1016/0040-4039(96)00416-9

  日期：1996.4

  2,2-Diethoxyvinyllithium can be readily generated from 2-bromo-1,1-diethoxyethylene by treatment with butyllithium. When dissolved in tetrahydrofuran, it can be stored at −25 °C for hours, but decomposes rapidly at 0 °C.

  通过用丁基锂处理，可以容易地从2-溴-1,1-二乙氧基乙烯生成2,2-二乙氧基乙烯基锂。溶于四氢呋喃后，可在-25°C下保存数小时，但在0°C下会迅速分解。
• TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES
  申请人：Liu Gang

  公开号：US20100324067A1

  公开（公告）日：2010-12-23

  The present invention relates to tetracyclodipyrano-coumarin compounds of general formula (I), wherein the substituents are defined herein. These compounds exihibit dual biological activities of anti human immunodeficiency virus type 1 (HIV-1) infection and anti- Mycobacterium Tuberculosis (TB) infection.

  本发明涉及通式（I）的四环二吡喃香豆素类化合物，其中取代基在此定义。这些化合物表现出抗人类免疫缺陷病毒类型1（HIV-1）感染和抗结核分枝杆菌（TB）感染的双重生物活性。
• TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF
  申请人：Institute of Mataria Medica, Chinese Academy of Medical Sciences

  公开号：EP2216335A1

  公开（公告）日：2010-08-11

  The present invention relates to tctracyclodipyrano-coumarin compounds of general formula (I), wherein the substituents are defined herein. These compounds exihibit dual biological activities of anti human immunodeficiency virus type 1 (HIV-1) infection and anti-Mycobacterium Tuberculosis (TB) infection.

  本发明涉及通式(I)的三环二吡喃香豆素化合物，其中取代基在本文中定义。这些化合物具有抗人类免疫缺陷病毒 1 型（HIV-1）感染和抗结核分枝杆菌（TB）感染的双重生物活性。
• 2-Ethoxyvinyllithiums and diethoxyvinyllithiums : what makes them stable or fragile?
  作者：Manfred Schlosser、Heng-xu Wei

  DOI：10.1016/s0040-4020(96)01075-7

  日期：1997.2

  The elusive (E)-2-ethoxyvinyllithium can be readily generated in tetrahydrofuran at -75 degrees C from (E)-1-bromo-2-ethoxyethylene by halogen/metal exchange and subsequently trapped with electrophiles. Alkylation opens a convenient entry to (E)-configurated enethers. (E)-2-Ethoxyvinyllithium decomposes rapidly at -50 degrees C whereas its (Z)-isomer, which lacks the possibility to eliminate lithium ethoxide in a favorable anti-periplanar process, is stable under the same conditions. (E)-1,2-Diethoxyvinyllithium even sustains reflux temperatures (approximately 75 degrees C). 2,2-Diethoxyvinyllithium and (Z)-1,2-diethoxyvinyllithium can be conserved at 0 degrees C although this time loss of alcoholate can occur in the anti-mode. Obviously it matters whether the energy-rich ethoxyacetylene is formed as the elimination product or simple acetylene, as in the case of (E)-2-ethoxyvinyllithium. (C) 1997, Elsevier Science Ltd.
• TETRACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF
  申请人：Institute of Mataria Medica, Chinese Academy of Medical Sciences

  公开号：EP2216335B1

  公开（公告）日：2014-03-12