2,4-dihydro-1H-benzo[b]imidazo[1,2-d][1,4]thiazine | 69294-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2,4-dihydro-1H-benzo[b]imidazo[1,2-d][1,4]thiazine
• 英文别名: 2,4-Dihydro-(1H)imidazo<2,1-c><1,4>-benzthiazin；2,4-dihydro-1H-imidazo[2,1-c][1,4]benzothiazine
• CAS: 69294-75-3
• 化学式: C₁₀H₁₀N₂S
• 分子量: 190.269
• InChiKey: SKHMQTAVUYLCBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(methylthio)-2H-1,4-benzothiazine 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 2,4-dihydro-1H-benzo[b]imidazo[1,2-d][1,4]thiazine
  参考文献：
  名称：

  Bhandari,K. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1979, vol. 17, p. 107 - 110

  摘要：

  DOI：

文献信息

• Cyclic amidine inhibitors of indolamine N-methyltransferase
  作者：Joshua Rokach、Pierre Hamel、Norman R. Hunter、Grant Reader、Clarence S. Rooney、Paul S. Anderson、Edward J. Cragoe、Lewis R. Mandel

  DOI：10.1021/jm00189a004

  日期：1979.3

  Syntheses of a large number of mono- and bicyclic, as well as a few tricyclic, amidine derivatives related to 2,3,4,6,7,8,-hexahydropyrrolo[1,2-a]pyrimidine (DBN) are reported. In vitro potencies for inhibition of the enzyme indolamine N-methyltransferase (INMT) from rabbit and human lung are presented. Four bicyclic amidine derivatives and 11 monocyclic derivatives were found to be equal or superior to DBN in in vitro potencies. With the bicyclic amidines, increasing ring size or introduction of substituents reduced activity. Among the monocyclic analogues, the most potent representatives were five- or six-membered systems with an exocyclic imino group, combined with methyl of ethyl substituents on the endocyclic nitrogen. Introduction of additonal substituents decreased inhibitory potency. 2,3,5,6-Tetrahydro-8H-imidazo[2,1-c][1,4]thiazine and 3-methyl-2-iminothiazolidine have been shown to cause inhibition of lung INMT when administered orally to rabbits.
• BHANDARI K.; VIRMANI V.; MURTI V. A.; JAIN P. C.; ANAND N., INDIAN J. CHEM., B17, NO 2, 107-110
  作者：BHANDARI K.、 VIRMANI V.、 MURTI V. A.、 JAIN P. C.、 ANAND N.

  DOI：——

  日期：——
• Bhandari,K. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1979, vol. 17, p. 107 - 110
  作者：Bhandari,K. et al.

  DOI：——

  日期：——