4,4'-Dimethyl-bis-thiobenzoyldisulfid | 20710-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-Dimethyl-bis-thiobenzoyldisulfid
• 英文别名: (4-Methylbenzenecarbothioyl)sulfanyl 4-methylbenzenecarbodithioate
• CAS: 20710-51-4
• 化学式: C₁₆H₁₄S₄
• 分子量: 334.551
• InChiKey: RYIZPBOZZKEWSI-UHFFFAOYSA-N

物化性质

• 熔点：
  136-137 °C
• 沸点：
  466.1±48.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4'-Dimethyl-bis-thiobenzoyldisulfid 在 Raney-Nickel W-2B 作用下， 以 苯 为溶剂， 以64%的产率得到1,1'-(1,2-乙炔二基)二(4-甲基苯)
  参考文献：
  名称：

  Latif, K. A.; Ali, M. Umar, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 5, p. 471 - 473

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(甲基)二硫代苯甲酸钠 以 正己烷 为溶剂， 反应 1.08h， 生成 4,4'-Dimethyl-bis-thiobenzoyldisulfid
  参考文献：
  名称：

  Kato, Shinzi; Sugino, Katsumi; Matsuzawa, Yukihiko, Liebigs Annalen der Chemie, 1981, # 10, p. 1798 - 1811

  摘要：

  DOI：

文献信息

• POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF
  申请人：Kopecková Pavla

  公开号：US20130156722A1

  公开（公告）日：2013-06-20

  Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates.

  本文描述了一种可生物降解的药物传递共轭物，用于有效地将生物活性物质传递给受试者。药物传递共轭物包括水溶性高分子量线性可生物降解聚合物骨架，该骨架包括通过第一（主链）可断裂连接剂相互连接的多个线性水溶性聚合物段，其中生物活性物质与至少一个水溶性聚合物段，至少一个可断裂连接剂或其组合共价键合。与先前的传递共轭物相比，这些共轭物具有许多优点。本文还描述了制备和使用这些共轭物的方法。
• Group 13 metal carbochalcogenoato complexes: Synthesis, X-ray structure analysis, and reactions
  作者：Norio Nakata、Shinzi Kato、Osamu Niyomura、Masahiro Ebihara

  DOI：10.1002/hc.21445

  日期：2018.12

  AbstractA series of alkali metal tetrakis(carbochalcogenoato)‐gallates and ‐indates M[M′(EOCR)4](solv.) (M = alkali metal; M′ = Ga, In; E = S, Se) and tris(carbodithioato)aluminum, ‐gallates and ‐indates M′ (SSCR)3 (M′ = Al, Ga, In) were prepared by the reactions of alkali metal carbochalcogenate with metal trihalogenides (M′X3; M′ = Al, Ga, In; X = Cl, Br) and by those of piperidinium carbodithioates or carbodithioic and carboselenoic acids with M′X3, respectively. An X‐ray molecular structure analysis revealed that they have an acetone molecule as a crystal solvent. The reactions of the potassium complexes K[M′ (EOCR)4](H2O) (E = S, Se) with methanol and primary and secondary amines gave the corresponding methyl ester and amides in good yields, while the reactions with iodomethane and iodine gave S‐ and Se‐methyl chalcogenoesters RCOEMe (E = S, Se) in good yields. Similar reactions of the tris(carbodithioato)gallates and ‐indates led to the corresponding O‐methyl thioesters, thioamides, and S‐methyl dithioesters in moderate to good yields. Oxidation of the tetrakis‐ and tris‐derivatives with iodine afforded the corresponding diacyl dichalcogenides (RCOE)2 (E = S, Se) and di(carbothioyl) disulfides in quantitative yields. These reactions appeared to occur on the carbonyl or selenium atom of the tetrakis compounds and on the sulfide sulfur or thiocarbonyl carbon atom of the tris‐compounds, respectively. A possible mechanism for these I2‐oxidation reactions is discussed.
• Kato, Shinzi; Goto, Masahisa; Hattori, Rikizoh, Chemische Berichte, 1985, vol. 118, # 4, p. 1668 - 1683
  作者：Kato, Shinzi、Goto, Masahisa、Hattori, Rikizoh、Nishiwaki, Koh-ichi、Mizuta, Masateru、Ishida, Masaru

  DOI：——

  日期：——
• Kato, Shinzi; Nishiwaki, Masataka; Inagaki, Satoshi, Chemische Berichte, 1985, vol. 118, # 4, p. 1684 - 1695
  作者：Kato, Shinzi、Nishiwaki, Masataka、Inagaki, Satoshi、Ohshima, Shigeru、Ohno, Yoshitaka、et al.

  DOI：——

  日期：——
• A Convenient Preparation of<i>N</i>-(Thioacylthio)-succinimides and -phthalimides
  作者：Shinzi Kato、Kenji Miyagawa、Rikizo Hattori、Masateru Mizuta、Masaru Ishida

  DOI：10.1055/s-1981-29589

  日期：——