Boron 4-methoxy-2-furanolates generated in situ from 5-unsubstituted and 5-monosubstituted 4-O-methyl tetronates undergo highly regioselective 3-hydroxyalkylations with aldehydes to give 5-unsubstituted and 5-monosubstituted 3-acyl-4-O-methyl tetronates, respectively, in good overall yields after oxidation of the intermediate alcohols with 2-iodoxybenzoic acid.
由 5-未取代和 5-单取代的 4-O- 甲基四
硼酸酯原位生成的 4-甲氧基-2-
呋喃醇酸
硼酯与醛发生高区域选择性 3-羟基烷基化反应,生成 5-未取代和 5-单取代的 3-酰基-4-O-甲基四
硼酸酯,中间醇与 2-iodoxybenzoic acid 氧化后,总产率良好。