(2S)-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-2-[[7-(diethylamino)-2-oxochromene-3-carbonyl]amino]-5-oxopentanoic acid | 1273151-88-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-2-[[7-(diethylamino)-2-oxochromene-3-carbonyl]amino]-5-oxopentanoic acid
• CAS: 1273151-88-4
• 化学式: C₂₄H₃₀N₄O₉S
• 分子量: 550.59
• InChiKey: SFANJYMAPAHLMP-IRXDYDNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  192
• 氢给体数：
  6
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  L-谷胱甘肽 (氧化型) 、 7-(二乙胺基)-2-氧代-2-苯并吡喃-3-羧酸N-琥珀酰亚胺酯 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以78.5%的产率得到(2S)-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-2-[[7-(diethylamino)-2-oxochromene-3-carbonyl]amino]-5-oxopentanoic acid
  参考文献：
  名称：

  A FRET approach for luminescence sensing Cr3+ in aqueous solution and living cells through functionalizing glutathione and glucose moieties

  摘要：

  A simple FRET-based approach to ratiometric fluorescence sensing of Cr3+ in aqueous solution using glutathione and glucose as building blocks was achieved, inspired to the binding motifs of Cr3+ in glucose tolerance factors (GTF). Selectivity and competition experiments showed that this system featured high sensitivity (detection limit <= 0.1 ppm) and excellent selectivity over other metal ions in buffer solution. Confocal fluorescence microscopy experiments had established the utility of the approach in monitoring Cr3+ within living cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.026

文献信息

• A FRET approach for luminescence sensing Cr3+ in aqueous solution and living cells through functionalizing glutathione and glucose moieties
  作者：Xiaoyue Hu、Xiaolin Zhang、Guangjie He、Cheng He、Chunying Duan

  DOI：10.1016/j.tet.2010.12.026

  日期：2011.2

  A simple FRET-based approach to ratiometric fluorescence sensing of Cr3+ in aqueous solution using glutathione and glucose as building blocks was achieved, inspired to the binding motifs of Cr3+ in glucose tolerance factors (GTF). Selectivity and competition experiments showed that this system featured high sensitivity (detection limit <= 0.1 ppm) and excellent selectivity over other metal ions in buffer solution. Confocal fluorescence microscopy experiments had established the utility of the approach in monitoring Cr3+ within living cells. (C) 2010 Elsevier Ltd. All rights reserved.