cyclohexyl 2-(pyridin-2-yl)acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: cyclohexyl 2-(pyridin-2-yl)acetate
• 英文别名: Cyclohexyl 2-pyridin-2-ylacetate
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: OFUHMRVPTBVQNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cyclohexyl 2-(pyridin-2-yl)acetate 以37%的产率得到
  参考文献：
  名称：

  OKITSU, MITSUHITO

  摘要：

  DOI：
• 作为产物：
  描述：

  2-吡啶乙酸盐酸盐 以74%的产率得到
  参考文献：
  名称：

  OKITSU, MITSUHITO

  摘要：

  DOI：

文献信息

• Metal-Free Aminothiation of Alkynes: Three-Component Tandem Annulation toward Indolizine Thiones from 2-Alkylpyridines, Ynals, and Elemental Sulfur
  作者：Zhengwang Chen、Pei Liang、Fan Xu、Zhen Deng、Lipeng Long、Guotian Luo、Min Ye

  DOI：10.1021/acs.joc.9b01802

  日期：2019.10.4

  A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C-C/C-N/C-S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields.

  开发了一种无金属的三组分环化反应，用于通过串联CC / CN / CS键的形成来合成吲哚嗪硫酮。在无催化剂的条件下，各种带有芳族乙醛和元素硫的2-烷基吡啶均能顺利进行，并以中等至极好的收率获得了所需的产物。
• Metal-free synthesis of indolizines through oxidative C C and C N bond formations of C (sp 3 ) H bonds
  作者：N. Naresh Kumar Reddy、Darapaneni Chandra Mohan、Subbarayappa Adimurthy

  DOI：10.1016/j.tetlet.2016.01.082

  日期：2016.3

  catalyzed synthesis of indolizine-1-carboxylates through oxidative CC and CN bond formations by the reaction of 2-pyridyl acetates with alkynes and alkenes without metal, oxidant, and base. This procedure is compatible with a broad range of functional groups in both alkynes and alkenes with good yields. The reaction proceeds through a tandem CC bond formation followed by an intramolecular cyclization

  碘催化乙酸2-吡啶酯与炔烃和没有金属，氧化剂和碱的烯烃的反应，通过氧化C C和C N键的形成，催化碘吲哚-1-羧酸酯的合成。该方法与炔烃和烯烃中的多种官能团相容，且收率良好。该反应通过串联C C键的形成进行，随后进行分子内环化。
• Copper-catalyzed aerobic oxidative amination of C(sp³)–H bonds: synthesis of imidazo[1,5-a]pyridines
  作者：Darapaneni Chandra Mohan、Sadu Nageswara Rao、Chitrakar Ravi、Subbarayappa Adimurthy

  DOI：10.1039/c5ob00381d

  日期：——

  Copper-catalyzed synthesis of imidazo[1,5-a]pyridine-1-carboxylates through oxidative amination of C(sp3)–H bonds under mild aerobic conditions with broad substrate scope is described. Use of naturally abundant air as the sole oxidant was found to be efficient and selective. The present protocol is also applicable for direct synthesis of functionalized imidazo[1,5-a]pyridines from amino acid derivatives

  铜催化的咪唑并[1,5 - a ]吡啶-1-羧酸铜的合成在温和的好氧条件下通过广泛的底物范围内的C（sp 3）-H键的氧化胺化进行了描述。发现使用自然丰富的空气作为唯一氧化剂是有效和选择性的。本协议也适用于从氨基酸衍生物直接合成功能化的咪唑并[1,5- a ]吡啶。
• Copper-mediated synthesis of pyrazolo[1,5-a]pyridines through oxidative linkage of C–C/N–N bonds
  作者：Darapaneni Chandra Mohan、Chitrakar Ravi、Sadu Nageswara Rao、Subbarayappa Adimurthy

  DOI：10.1039/c5ob00018a

  日期：——

  Copper-mediated synthesis of pyrazolo[1,5-a]pyridine-3-carboxylates through oxidative linkage of C–C and N–N bonds under mild reaction conditions with broad substrate scope is described.

  通过铜介导的合成，描述了在温和的反应条件下通过氧化连接C-C和N-N键来合成吡唑并[1,5-a]吡啶-3-羧酸酯，具有广泛的底物范围。
• Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a]pyridine derivatives
  作者：Chitrakar Ravi、Arem Qayum、Darapaneni Chandra Mohan、Shashank K. Singh、Subbarayappa Adimurthy

  DOI：10.1016/j.ejmech.2016.11.037

  日期：2017.1

  Copper–mediated synthesis of various pyrazolo[1, 5–a]pyridine-3-carboxylates has been described. The biological activities of these molecules have been evaluated against various human cancer cell lines A549 (Lung adenocarcinoma cell line), MCF-7 (Breast carcinoma cell line), HCT-116 (Colon cancer cell line), and PC-3 (Prostate cancer cell line) through SRB assay. Compound 247 led to accumulation MCF-7 cells

  已经描述了铜介导的各种吡唑并[1，5–a]吡啶-3-羧酸酯的合成。已经评估了这些分子对各种人类癌细胞系A549（肺腺癌细胞系），MCF-7（乳腺癌细胞系），HCT-116（结肠癌细胞系）和PC-3（前列腺癌）的生物学活性。细胞系）通过SRB分析。化合物247导致MCF-7细胞在G1期积累，并揭示了其在有丝分裂细胞周期进程中的重要作用。