2,4-二溴-3-甲基苯酚 | 13321-75-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2,4-二溴-3-甲基苯酚
• 英文名称: 2,4-dibromo-3-methylphenol
• 英文别名: 2.4-Dibrom-m-kresol
• CAS: 13321-75-0
• 化学式: C₇H₆Br₂O
• 分子量: 265.932
• InChiKey: SNTBBWYRKIAIJR-UHFFFAOYSA-N

物化性质

• 熔点：
  64 °C
• 沸点：
  264.7±35.0 °C(Predicted)
• 密度：
  1.948±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4-二溴-3-甲基苯酚 在 盐酸 、 氢氧化钾 、 sodium hydroxide 、 镍 作用下， 生成 5,5'-dimethyl-2,2'-methanediyl-di-phenol
  参考文献：
  名称：

  Godfrey et al., Journal of Applied Chemistry, 1957, vol. 7, p. 440,443

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酸间甲苯酯 在 溴 、 溶剂黄146 作用下， 生成 2,4-二溴-3-甲基苯酚
  参考文献：
  名称：

  Godfrey et al., Journal of Applied Chemistry, 1957, vol. 7, p. 440,443

  摘要：

  DOI：

文献信息

• Do Statins Afford Neuroprotection in Patients with Cerebral Ischaemia and Stroke?
  作者：Carl J. Vaughan、Norman Delanty、Craig T. Basson

  DOI：10.2165/00023210-200115080-00002

  日期：——

  An emerging body of evidence indicates that β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or ‘statins’, provide neuroprotection in addition to reducing ischaemic stroke. Statins reduce the incidence of ischaemic stroke by stabilising atherosclerotic plaques in the precerebral vasculature and through antithrombotic actions, and the neuroprotective effects of statins may confer significant clinical benefit. Some of these neuroprotective effects are likely to be cholesterol independent and mediated by the interruption of isoprenoid biosynthesis. Therapy with statins may modulate endothelial function and preserve blood flow to regions exposed to an ischaemic insult. In particular, statin-mediated preservation of endothelial nitric oxide synthase activity in cerebral vasculature, especially in the ischaemic penumbra, may limit neurological deficit. Moreover, putative anti-inflammatory and antioxidant properties of statins may confer additional neuroprotection. Further large clinical trials are necessary to address the role of statin therapy in the primary prevention of stroke, small vessel cerebrovascular disease and vascular dementia.

  越来越多的证据表明，β-羟基-β-甲基戊二酰辅酶 A（HMG-CoA）还原酶抑制剂或 "他汀类药物 "除了能减少缺血性中风外，还能提供神经保护。他汀类药物通过稳定脑前血管中的动脉粥样硬化斑块和抗血栓作用降低缺血性中风的发病率，他汀类药物的神经保护作用可能会带来显著的临床益处。其中一些神经保护作用可能与胆固醇无关，而是通过中断异肾上腺素的生物合成来实现。他汀类药物可调节内皮功能，保护缺血区域的血流。特别是，他汀类药物介导的脑血管内皮一氧化氮合酶活性的保持，尤其是在缺血半影区，可能会限制神经功能的缺失。此外，他汀类药物可能具有的抗炎和抗氧化特性还能提供额外的神经保护作用。他汀类药物在中风、小血管性脑血管病和血管性痴呆的一级预防中的作用还需要进一步的大型临床试验来验证。
• FLAME-RETARDANT MOLDED ARTICLE AND FABRIC PRODUCT
  申请人：YKK Corporation

  公开号：EP1486606A1

  公开（公告）日：2004-12-15

  A product (a molded article and a fabric product) which is made of a flame retardancy-imparting material or contains or/and is coated with the flame retardancy-imparting material, wherein the flame retardancy-imparting material comprises 100 parts by weight of a synthetic resin and 1 to 400 parts by weight of a flame-retardant containing an inorganic flame-retardant, preferably the inorganic flame-retardant which exhibits such a volume change as expansion and/or foaming at the time of combustion, more preferably at least one member selected from the group consisting of hydrated metallic compounds and thermally expansible graphite, the flame-retardant being dispersed in the synthetic resin. The molded article containing or/and coated with the flame retardancy-imparting material includes not only the case that the product is manufactured from a synthetic resin material containing the above-mentioned flame-retardant, but also the cases that a synthetic resin material containing the above-mentioned flame-retardant is contained in the product (including kneading, penetration, etc.) and that the surface (including a back surface) of the product is coated with a synthetic resin material containing the above-mentioned flame-retardant. Such flame-retardant products are useful as various molded articles and fabric products, such as surface fasteners, slide fasteners, and resin buttons.

  一种由阻燃材料制成或含有或/和涂有阻燃材料的产品（模塑制品和织物制品），其中阻燃材料包括 100 份（重量）合成树脂和 1 至 400 份（重量）含有无机阻燃剂的阻燃剂、无机阻燃剂最好在燃烧时表现出膨胀和/或发泡等体积变化，更优选至少一种从水合金属化合物和热膨胀石墨组成的组中选出的无机阻燃剂，阻燃剂分散在合成树脂中。含有或/和涂有阻燃材料的成型品不仅包括由含有上述阻燃剂的合成树脂材料制造的产品，还包括含有上述阻燃剂的合成树脂材料被包含在产品中（包括揉捏、渗透等）以及产品表面（包括背面）涂有含有上述阻燃剂的合成树脂材料的情况。这种阻燃产品可用作各种模制产品和织物产品，如表面紧固件、滑动紧固件和树脂钮扣。
• Fang, Lei; Zhang, Haun; Fang, Xubin, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53, # 5, p. 635 - 641
  作者：Fang, Lei、Zhang, Haun、Fang, Xubin、Gou, Shaohua、Cheng, Lin

  DOI：——

  日期：——
• SOME MONO AND DIBROMO DERIVATIVES OF META-CRESOL
  作者：Ralph C. Huston、James A. Hutchinson

  DOI：10.1021/ja01343a036

  日期：1932.4
• Some Mono and Dibromo Derivatives of Meta Cresol. II
  作者：Ralph C. Huston、Walter J. Peterson

  DOI：10.1021/ja01336a076

  日期：1933.9