1-氧杂-4,10,16-三硫杂-7,13-二氮杂环十八烷 | 343372-28-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-氧杂-4,10,16-三硫杂-7,13-二氮杂环十八烷
• 英文名称: 7,13-diaza-4,10,16-trithia-1-oxacyclooctadecane
• 英文别名: 1-Oxa-4,10,16-trithia-7,13-diazacyclooctadecane
• CAS: 343372-28-1
• 化学式: C₁₂H₂₆N₂OS₃
• 分子量: 310.549
• InChiKey: SLJKDXMTQMYBDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  8-羟基喹啉-2-甲醛 、 1-氧杂-4,10,16-三硫杂-7,13-二氮杂环十八烷 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 4.0h， 以75%的产率得到2,2'-[1-氧杂-4,10,16-三硫杂-7,13-二氮杂环十八烷-7,13-二基二(亚甲基)]二(8-喹啉醇)
  参考文献：
  名称：

  Bis-8-hydroxyquinoline-Armed Diazatrithia-15-crown-5 and Diazatrithia-16-crown-5 Ligands:  Possible Fluorophoric Metal Ion Sensors

  摘要：

  The synthesis and preliminary photophysical properties of a series of diazatrithia-15-crown-5 and diazatrithia-16-crown-5 ligands containing two 8-hydroxyquinoline sidearms are reported. The ligands were prepared by a two-step process. First, diazatrithiacrown ethers 11 and 12 were prepared by treating bis(alpha -chloroamide)5 with various dimercaptans followed by reduction using a boron-THF complex. Hydroxymethyl-substituted macrocycle 12 was rearranged to hydroxysubstituted diazatrithia-16-crown-5 in refluxing aqueous HCl. Macrocyclic diamines 11-13 were converted to either 5-chloro-8-hydroxyquinolin-7-ylmethyl-sudstituted diazatrithiacrown ethers 14-16 by a Mannich aminomethylation reaction or to 8-hydroxyquinolin-2-ylmethyl-substituted diazatrithiacrown ethers 17-19 by reductive amination using 8-hydroxyquinoline-2-carboxaldehyde. Preliminary photophysical studies show that ligands 16 and 19 exhibit increased fluorescence in the presence of Zn2+, indicating that these ligands could be chemical sensors for Zn2+.

  DOI：

  10.1021/jo0017584
• 作为产物：
  描述：

  7,13-diaza-1-oxa-4,10,16-trithiacyclooctadecane-6,14-dione 在 硼烷四氢呋喃络合物 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以79%的产率得到1-氧杂-4,10,16-三硫杂-7,13-二氮杂环十八烷
  参考文献：
  名称：

  Bis-8-hydroxyquinoline-Armed Diazatrithia-15-crown-5 and Diazatrithia-16-crown-5 Ligands:  Possible Fluorophoric Metal Ion Sensors

  摘要：

  The synthesis and preliminary photophysical properties of a series of diazatrithia-15-crown-5 and diazatrithia-16-crown-5 ligands containing two 8-hydroxyquinoline sidearms are reported. The ligands were prepared by a two-step process. First, diazatrithiacrown ethers 11 and 12 were prepared by treating bis(alpha -chloroamide)5 with various dimercaptans followed by reduction using a boron-THF complex. Hydroxymethyl-substituted macrocycle 12 was rearranged to hydroxysubstituted diazatrithia-16-crown-5 in refluxing aqueous HCl. Macrocyclic diamines 11-13 were converted to either 5-chloro-8-hydroxyquinolin-7-ylmethyl-sudstituted diazatrithiacrown ethers 14-16 by a Mannich aminomethylation reaction or to 8-hydroxyquinolin-2-ylmethyl-substituted diazatrithiacrown ethers 17-19 by reductive amination using 8-hydroxyquinoline-2-carboxaldehyde. Preliminary photophysical studies show that ligands 16 and 19 exhibit increased fluorescence in the presence of Zn2+, indicating that these ligands could be chemical sensors for Zn2+.

  DOI：

  10.1021/jo0017584

文献信息

• Bis-8-hydroxyquinoline-Armed Diazatrithia-15-crown-5 and Diazatrithia-16-crown-5 Ligands:  Possible Fluorophoric Metal Ion Sensors
  作者：R. Todd Bronson、Jerald S. Bradshaw、Paul B. Savage、Saowarux Fuangswasdi、Sang Chul Lee、Krzysztof E. Krakowiak、Reed M. Izatt

  DOI：10.1021/jo0017584

  日期：2001.7.1

  The synthesis and preliminary photophysical properties of a series of diazatrithia-15-crown-5 and diazatrithia-16-crown-5 ligands containing two 8-hydroxyquinoline sidearms are reported. The ligands were prepared by a two-step process. First, diazatrithiacrown ethers 11 and 12 were prepared by treating bis(alpha -chloroamide)5 with various dimercaptans followed by reduction using a boron-THF complex. Hydroxymethyl-substituted macrocycle 12 was rearranged to hydroxysubstituted diazatrithia-16-crown-5 in refluxing aqueous HCl. Macrocyclic diamines 11-13 were converted to either 5-chloro-8-hydroxyquinolin-7-ylmethyl-sudstituted diazatrithiacrown ethers 14-16 by a Mannich aminomethylation reaction or to 8-hydroxyquinolin-2-ylmethyl-substituted diazatrithiacrown ethers 17-19 by reductive amination using 8-hydroxyquinoline-2-carboxaldehyde. Preliminary photophysical studies show that ligands 16 and 19 exhibit increased fluorescence in the presence of Zn2+, indicating that these ligands could be chemical sensors for Zn2+.