4-Dibutylamino-phenol | 16222-29-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-Dibutylamino-phenol
• 英文别名: 4-N,N-dibutylaminophenol；4-hydroxy-N,N-dibutylaniline；4-(dibutylamino)phenol
• CAS: 16222-29-0
• 化学式: C₁₄H₂₃NO
• 分子量: 221.343
• InChiKey: FLVCXTAJLMMZHF-UHFFFAOYSA-N

物化性质

• 沸点：
  150-154 °C(Press: 1.8 Torr)
• 密度：
  0.984±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Dibutylamino-phenol 、 在 potassium carbonate 作用下， 以 氘代二甲亚砜 为溶剂， 以52 %的产率得到
  参考文献：
  名称：

  四氢异喹啉衍生物的设计、合成及生物抗肿瘤评价

  摘要：

  癌症作为一个公共卫生问题，是全世界死亡的主要原因。四氢异喹啉衍生物具有有效的生物活性，可作为抗肿瘤药物的潜在治疗剂。在这项工作中，我们设计并合成了一系列新型四氢异喹啉化合物，并评估了它们对几种代表性人类癌细胞系的抗肿瘤活性。结果表明，绝大多数化合物对HCT116、MDA-MB-231、HepG2和A375等癌细胞系表现出良好的抑制活性。

  DOI：

  10.1016/j.bmcl.2024.129824
• 作为产物：
  描述：

  N,N-二丁基-N-(4-甲氧基苯基)胺 在 水 、 碳酸氢钠 、 methanol-ether 作用下， 以 氢溴酸 为溶剂， 反应 2.5h， 以to give 4-hydroxy-N,N-dibutylaniline的产率得到4-Dibutylamino-phenol
  参考文献：
  名称：

  1,3-Dioxolane derivatives as cholesterol-lowering agents

  摘要：

  化合物的式子(I): ##STR1## 其中n为2或3; p为0,1或2; q为0,1或2; X为氧或S(O).sub.t，其中t为0,1或2; 每个R.sup.1独立地为卤素，低烷基，低烷氧基或三氟甲基; 每个R.sup.2独立地为卤素或低烷基; R.sup.3为硝基或--N(R.sup.5)R.sup.6，其中R.sup.5为氢或低烷基; R.sup.6为氢，低烷基，低烷基磺酰基或--C(Y)R.sup.7，其中Y为氧或硫，R.sup.7为氢，低烷基，低烷氧基或--N(R.sup.8)R.sup.9，其中R.sup.8为氢或低烷基，R.sup.9为氢，低烷基或低烷氧羰基; 或者R.sup.5和R.sup.6与N一起形成吡咯烷基，哌啶基，吗啉基，硫代吗啉基或哌嗪基，其中哌嗪基在4位上可以选择性地被--N(O)R.sup.10取代，其中R.sup.10为氢，低烷基，低烷氧基或氨基; R.sup.4为氢或低烷基，作为单一立体异构体或其混合物; 以及它们的药学上可接受的盐，在治疗以高胆固醇血症为特征的疾病状态方面有用。

  公开号：

  US05158949A1

文献信息

• Production of aminophenols
  申请人：Ciba Specialty Chemicals Corporation

  公开号：US05908961A1

  公开（公告）日：1999-06-01

  A method of producing N,N-disubstituted aminophenols of the general formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a saturated or unsaturated aliphatic hydrocarbyl, cycloalkyl, aralkyl, the phenyl ring of which may be further substituted, alkoxyalkyl, or a cycloalkylalkyl, except that R.sub.1 and R.sub.2 are not simultaneously methyl and R' represents hydrogen, halogen, nitro, cyano, alkyl or alkoxy, which comprises reacting an aminophenol of general formula ##STR2## wherein R.sub.3 represents hydrogen or R.sub.1, and R' is as defined above, with an organic halide species of general formula R.sub.2 X wherein R.sub.2 is as defined above and X is halogen under aqueous acidic conditions with the periodic addition of an acid trapping agent in such a way that continuous monitoring of pH is not required.

  一种生产一般式为##STR1##的N,N-二取代氨基酚的方法，其中R.sub.1和R.sub.2相同或不同，每个代表饱和或不饱和的脂肪烃基、环烷基、芳基烷基，其苯环可能进一步取代、烷氧基烷基或环烷基烷基，但R.sub.1和R.sub.2不能同时是甲基，R'代表氢、卤素、硝基、氰基、烷基或烷氧基，包括在水性酸性条件下与一般式为R.sub.2 X的有机卤代物种反应，其中R.sub.2如上定义，X为卤素，并定期添加酸捕获剂，以使不需要连续监测pH。
• Anthraquinone compound and water-based ink-jet recording ink containing the compound
  申请人：——

  公开号：US20030078318A1

  公开（公告）日：2003-04-24

  It is disclosed that in ink for ink jet recording, containing at least a water-insoluble coloring matter, water and a resin as main components to form an emulsion, anthraquinone compounds represented by at least the following the formula (1) 1 especially those in which X is an oxygen atom, R 1 is represented by the formula (2) 2 and further R 8 is —NR 12 R 13 , are useful as coloring matters excellent in water resistance and also in light fastness and compatibility with a resin and that ink for ink jet recording using the same and exhibiting excellent performances in light fastness and storage stability, especially as ink of an ink jet recording system, can forma high-quality, unblotted image, a recorded image having also excellent property in water resistance.

  本发明涉及一种墨水喷射记录用墨水，其包含至少一种水不溶性着色剂、水和树脂作为主要组成部分形成乳液，其中所述着色剂为至少以下式（1）所表示的蒽醌化合物1，特别是其中X为氧原子，R1为式（2）所表示的基团2，进一步地，R8为—NR12R13，这些着色剂不仅具有优异的耐水性、耐光性和与树脂的相容性，而且使用该墨水喷射记录的墨水表现出优异的耐光性和储存稳定性，特别是作为喷墨记录系统的墨水，能够形成高质量、无污点的图像，记录的图像也具有优异的耐水性。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Shinohata Masaaki

  公开号：US20110133121A1

  公开（公告）日：2011-06-09

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明涉及一种从有机胺、碳酸衍生物和含有一种或多种羟基化合物中制得的N-取代氨基甲酸酯的制备方法，其中使用一种含有冷凝器的脲类生产反应容器反应有机胺、碳酸衍生物和羟基化合物，将含有羟基化合物的气体、来自碳酸衍生物衍生的含有羰基基团的化合物、以及在反应中形成的氨气体引入到脲类生产反应容器中的冷凝器中，使羟基化合物和含有羰基基团的化合物冷凝，其中在冷凝的羟基化合物中所含有的羟基化合物与冷凝的含有羰基基团的化合物中所含有的羰基基团的化合物的比例为1或更多，而且在从冷凝器中回收的氨气体中所含有的羰基基团（—C(═O)—）数与氨分子数的比例为1或更少。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, and Composition for Transfer and Storage of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20140194650A1

  公开（公告）日：2014-07-10

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种从有机胺、碳酸酯衍生物和含有一种或多种羟基化合物中制备N-取代的氨基甲酸酯的方法，其中利用一种尿素生产反应容器反应有机胺、碳酸酯衍生物和羟基化合物，该反应容器配有冷凝器，将含有羟基化合物的气体、由碳酸酯衍生物产生的含有羰基基团的化合物以及在反应中生成的氨引入到尿素生产反应容器中的冷凝器中，将羟基化合物和含有羰基基团的碳酸酯衍生物冷凝，其中在冷凝的羟基化合物中所含的羟基化合物的化学计量比与所冷凝的含有羰基基团的化合物的化学计量比为1或更多，而且所含有羰基基团的化合物中所含的羰基基团（-C(═O)-）的数量与从冷凝器中回收的氨分子数量的比率为1或更小。
• Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0126449A1

  公开（公告）日：1984-11-28

  Novel compounds of the general formula and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4, and R5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R1 is methyl, R4 is not methyl; or R2 and R3 together form -OCH2O-; R6, R7, R8, R9 and R10 are each independently hydrogen, lower acyl, aminocarbonyl-methyl, arylcyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or R6 and R7 together form -CH = CH-CH = CH-; R7 and R8 together form -OCH2O -; R11 and R12 are each independently hydrogen or lower alkyl; and W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial infarction.

  通式为 及其药学上可接受的酯和酸加成盐，其中 R1、R2、R3、R4 和 R5 各自独立地为氢、低级烷基、低级烷氧基、氰基、三氟甲基、卤代、低级烷硫基、低级烷基亚磺酰基、低级烷基磺酰基、N-可选取代的烷基氨基，但当 R1 为甲基时，R4 不是甲基；或 R2 和 R3 共同形成 -OCH2O-； R6、R7、R8、R9 和 R10 各自独立地为氢、低级酰基、氨基羰基甲基、芳基氰基、低级烷基、低级烷氧基、三氟甲基、卤代、低级烷硫基、低级烷基亚磺酰基、低级烷基磺酰基、二低级烷基氨基；或 R6 和 R7 共同形成 -CH = CH-CH = CH-； R7 和 R8 共同形成 -OCH2O -； R11 和 R12 各自独立地为氢或低级烷基；以及 W 是氧或硫。 这些心脏选择性化合物具有钙离子进入阻断特性，因此可用于治疗心血管疾病，包括心律失常、变异型和运动诱发的心绞痛和心肌梗塞。