decamethylene bis(pyridinium bromide) | 6266-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: decamethylene bis(pyridinium bromide)
• 英文别名: 1,10-bis(pyridinio)decane dibromide；1,10-bis(pyridinium)-decane dibromide；decylidene-1,10-dipyridinium dibromide；[1,10-bis(1-pyridinium)decane]*2Br；1,1'-decanediyl-bis-pyridinium; dibromide；1,1'-Decandiyl-bis-pyridinium; Dibromid；1-(10-Pyridin-1-ium-1-yldecyl)pyridin-1-ium;bromide
• CAS: 6266-40-6
• 化学式: 2Br*C₂₀H₃₀N₂
• 分子量: 458.28
• InChiKey: CAIVAEUWUYOERX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.09
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  7.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  decamethylene bis(pyridinium bromide) 、 cucurbit[8]uril 在 盐酸 、 zinc(II) chloride 作用下， 以 水 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  葫芦[8]uril宿主中1,4-丁二吡啶鎓和1,10-癸二烯双吡啶鎓阳离子客体的扭曲构象

  摘要：

  1,4-Butylidenededipyridinium (C 4 DP 2+ ) 和 1,10-decylidenededipyridinium (C 10 DP 2+ ) 阳离子客体在水溶液中与葫芦 [8] uril (Q[8]) 形成高度稳定的 1:1 包合物） 主持人。包合物的单晶结构分析表明，C n DP 2+ (n = 4, 10) 阳离子客体的烷基链采用非常规的扭曲构象，这归因于有利的主客体相互作用（包括电荷-偶极子和疏水相互作用）当结合在 Q[8] 宿主的腔内时。此外，它们的晶体结构表明烷基链和芳香基团可以同时被包封到 Q[8] 主体中，并且烷基链比芳香基团更容易被包封到 Q[8] 主体中。

  DOI：

  10.1002/ejoc.201001504
• 作为产物：
  描述：

  吡啶 、 1,10-二溴癸烷 以 乙腈 为溶剂， 反应 10.0h， 以71.3%的产率得到decamethylene bis(pyridinium bromide)
  参考文献：
  名称：

  通过超分子聚合物网络的局限性原位生成AgI量子点：一种超灵敏响应的新方法。

  摘要：

  已经成功地开发了一种通过限制基于柱[5]芳烃的超分子聚合物网络原位产生AgI量子点的新方法。超分子聚合物网络（SPN-QP）是通过使用双-8-羟基喹啉修饰的支柱[5]芳烃衍生物作为主体（H-QP）和双吡啶修饰的癸烷（G-PD）构建的。SPN-QP对Ag +表现出超敏反应。检测下限约为7.44×10-9M。有趣的是，当将I-添加到SPN-QP + Ag +系统中时，观察到了出乎意料的强烈的暖白色荧光发射。经过carefu调查，我们发现强的暖白荧光发射可能归因于在超分子聚合物网络（SPN-QP）的限制下AgI量子点的原位形成。基于这种方法，实现了I-的超灵敏检测。I-的检出限为4.40×10-9M。本研究为超分子聚合物网络的局限下量子点的原位形成和离子的超灵敏检测提供了一种新的方法。

  DOI：

  10.1002/asia.201901084

文献信息

• Supramolecular hydrogels formed from poly(viologen) cross-linked with cyclodextrin dimers and their physical properties
  作者：Yoshinori Takashima、Yang Yuting、Miyuki Otsubo、Hiroyasu Yamaguchi、Akira Harada

  DOI：10.3762/bjoc.8.182

  日期：——

  (CD) as a host molecule, because CD effectively forms polyrotaxanes with polymers. Herein we report the formation of supramolecular hydrogels with an alpha-CD dimer (alpha,alpha-CD dimer) as a topological linker molecule, and a viologen polymer (VP) as the polymer chain. The supramolecular hydrogel of alpha,alpha-CD dimer/VP forms a self-standing gel, which does not relax (G' > G'') in the frequency range

  具有非共价键的超分子材料因其与仅由共价键形成的材料不同的独特性质而备受关注。特别有趣的是沿着聚合物链穿梭的拓扑复合物的转子分子。这些分子的穿梭应大大提高抗拉强度。我们的研究采用环糊精 (CD) 作为主体分子，因为 CD 可有效地与聚合物形成聚轮烷。在本文中，我们报告了以 α-CD 二聚体（α，α-CD 二聚体）作为拓扑连接分子和紫罗碱聚合物 (VP) 作为聚合物链的超分子水凝胶的形成。α,α-CD 二聚体/VP 的超分子水凝胶形成自立式凝胶，在 0.01-10 rad.s(-1) 的频率范围内不会松弛 (G' > G'')。另一方面，添加双吡啶基十亚甲基 (PyC(10)Py) 作为竞争客体后，超分子水凝胶会分解。此外，β-CD 二聚体（β，β-CD 二聚体）与 VP 不形成超分子水凝胶，表明 VP 的 C(10) 单元和 α，α-CD 二聚体的 α-CD 单元之间的复合在超分子水凝胶的形成中起重要作用。
• Construction and isomeric transformation of polyoxometalates directed by 1,ω-bis(pyridinium)alkane templates
  作者：Yun-Yin Niu、Ling-Fang Wang、Xiao-Rui Lv、Hai-Juan Du、Yong-Zhen Qiao、Hong-Mei Wang、Li-Sha Song、Ben-Lai Wu、Hong-Wei Hou、Seik Weng Ng

  DOI：10.1039/c1ce05245d

  日期：——

  propane]2[α-Mo8O26] (1), [1,4-bis(pyridinium)butane]2[1D-Mo8O26] (2), [1,5-bis(pyridinium)pentane]2[θ-Mo8O26] (3), [1,6-bis(pyridinium)hexane]2[1D-Mo8O26] (4), [1,7-bis(pyridinium)heptane]2[β-Mo8O26] (5), [1,8-bis(pyridinium)octane]2[θ-Mo8O26] (6), [1,9-bis(pyridinium)nonane]2[(α + β)-Mo8O26] (7), [1,10-bis(pyridinium)decane]2[β-Mo8O26] (8), [1,11-bis(pyridinium)undecane]2[β-Mo8O26] (9), [1,12-bis(pyri

  十种新型的无机-有机杂多金属氧酸盐，即[1,3-双（吡啶）丙烷] 2 [ α- Mo 8 O 26 ]（1），[1,4-双（吡啶）丁烷] 2 [1D-Mo 8 O 26 ]（2），[1,5-双（吡啶）戊烷] 2 [ θ- Mo 8 O 26 ]（3），[1,6-双（吡啶）正己烷] 2 [1D-Mo 8 O 26 ]（4），[1,7-双（吡啶）庚烷] 2 [ β- Mo 8 O 26]（5），[1,8-双（吡啶）辛烷] 2 [ θ- Mo 8 O 26 ]（6），[1,9-双（吡啶）壬烷] 2 [（α + β）-Mo 8 ø 26 ]（7），[1,10-二（吡啶鎓）癸烷] 2 [ β -Mo 8 ø 26 ]（8），[1,11双（吡啶）十一烷] 2 [ β -Mo 8 Ô 26 ]（9），[1,12-双（吡啶）十二烷] 2 [ γ-Mo 8 O 26 ]（10），（方案1）是在水热反应条件下
• Kinetic Control of Threading of Cyclodextrins onto Axle Molecules
  作者：Tomoya Oshikiri、Yoshinori Takashima、Hiroyasu Yamaguchi、Akira Harada

  DOI：10.1021/ja053532u

  日期：2005.9.1

  We report here, for the first time, kinetic control of the face-direction of cyclodextrin (CD) in the construction of a pseudo-rotaxane with an alkyl chain bearing pyridyl end caps. The yields of complexes of CDs with guest alkyl derivatives were controlled by the simple change of the position and the number of methyl groups bound to the pyridyl moiety. Single-substituted pyridyl groups attached to the ends of the alkyl chain regulated the rate for CDs passing them. Two methyl substituents could clearly govern the degree of complex formation of CD with guest molecules and resulted in the distinction of face-direction of CD molecules entering the gates at guest ends.
• Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implications
  作者：Kamil Musilek、Marketa Komloova、Vlasta Zavadova、Ondrej Holas、Martina Hrabinova、Miroslav Pohanka、Vlastimil Dohnal、Florian Nachon、Martin Dolezal、Kamil Kuca、Young-Sik Jung

  DOI：10.1016/j.bmcl.2010.01.034

  日期：2010.3

  Reversible inhibitors (e. g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Carbamate inhibitors are known for many undesirable side effects related to the reversible inhibition of AChE. In contrast, this paper describes 20 newly prepared bispyridinium inhibitors of potential concern for MG. Although some compounds from this series have been known before, they were not assayed for cholinesterase inhibition yet.The newly prepared compounds were evaluated in vitro on human erythrocyte AChE and human plasmatic butyrylcholinesterase (BChE). Their inhibitory ability was expressed as IC(50) and compared to standard carbamate drugs. Three compounds presented promising inhibition (in mu M range) of both enzymes in vitro similar to the used standards. The novel inhibitors did not present selectivity between AChE and BChE. Two newly prepared compounds were chosen for docking studies and confirmed apparent pi-pi or pi-cationic interactions aside enzyme's catalytic sites. The kinetics assay confirmed non-competitive inhibition of AChE by two best newly prepared compounds. (C) 2010 Elsevier Ltd. All rights reserved.
• 258. Synthetic neuromuscular blocking agents. Part I. Heterocyclic decamethylenebis(quaternary ammonium salts)
  作者：E. P. Taylor

  DOI：10.1039/jr9510001150

  日期：——