N-(2-hydroxy-ethyl)-N-phenyl-urea | 118176-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-hydroxy-ethyl)-N-phenyl-urea
• 英文别名: N-(2-Hydroxy-aethyl)-N-phenyl-harnstoff；1-(2-Hydroxyethyl)-1-phenylurea
• CAS: 118176-48-0
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: PMOGVVMUSYQXOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  硝基脲 、 N-苯基乙醇胺 生成 N-(2-hydroxy-ethyl)-N-phenyl-urea
  参考文献：
  名称：

  New Compounds. Some Aryl and Aralkyl Ureas

  摘要：

  DOI：

  10.1021/ja01230a047

文献信息

• ANTIMICROBIAL CATIONIC POLYAMINES
  申请人：International Business Machines Corporation

  公开号：US20150342984A1

  公开（公告）日：2015-12-03

  Antimicrobial, non-hemolytic cationic polyamines were prepared by treating partially N-acylated polyethylenimines and/or partially oxidized polyethylenimines with a protic acid. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant urea groups, which can be introduced via a cyclic carbonate comprising a pendant urea group. The cationic polyamines can be active against a tuberculosis mycobacterium at low concentration. The cationic polyamines are also effective against Gram-negative Escherichia coli and Pseudomonas aeruginosa , Gram-positive Staphylococcus aureus , and fungus Candida albicans in solution and in the form of a film.

  抗菌、非溶血性阳离子聚胺是通过用一种质子酸处理部分N-酰化聚乙烯亚胺和/或部分氧化聚乙烯亚胺制备的。这些阳离子聚胺可以具有线性或支链聚乙烯亚胺骨架结构。最好的情况是，这些阳离子聚胺包括吊挂脲基团，可以通过含有吊挂脲基团的环状碳酸酯引入。这些阳离子聚胺在低浓度下可以对结核分枝杆菌起作用。这些阳离子聚胺对革兰氏阴性大肠杆菌和铜绿假单胞菌、革兰氏阳性金黄色葡萄球菌以及真菌白色念珠菌在溶液中和膜的形式中也具有有效性。
• BIODEGRADABLE BLOCK POLYMERS FOR DRUG DELIVERY, AND METHODS RELATED THERETO
  申请人：Hedrick James

  公开号：US20110152167A1

  公开（公告）日：2011-06-23

  A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol; and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of urea groups, a carboxylic acid groups, and mixtures thereof. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.

  一种可生物降解的嵌段共聚物被披露，包括源自聚醚醇的亲水性块；和包括由聚醚醇引发的第一环状羰基单体的环开聚合得到的疏水性块，该第一重复单元包括一个侧链基团，该侧链基团包括从尿素基团、羧酸基团或它们的混合物中选择的功能基团。疏水性块的任何侧链均不包括共价结合的生物活性物质。该嵌段共聚物在水中自组装形成适合通过非共价相互作用固定生物活性物质的胶束，并且根据ASTM D6400标准，该嵌段共聚物在180天内生物降解60%。
• THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS
  申请人：Zask Arie

  公开号：US20090098086A1

  公开（公告）日：2009-04-16

  The invention relates to thienopyrimidine and pyrazolopyrimidine compounds of the Formulas (Ia) and (IIa), or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein compositions comprising the compounds, and methods for making and using the compounds.

  该发明涉及Formula (Ia)和Formula (IIa)的噻吡嘧啶和吡唑嘧啶化合物，或其药用可接受的盐，其中组成变量如本文所定义的那样，包括该化合物的组合物，以及制备和使用该化合物的方法。
• ANTIMICROBIAL HYDROGELS, METHODS OF PREPARATION THEREOF, AND ARTICLES THEREFROM
  申请人：Coady Daniel Joseph

  公开号：US20120231060A1

  公开（公告）日：2012-09-13

  A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P′ covalently linked at respective first end units to a branched first core group C′, b) three or more divalent poly(alkylene oxide) chains P″ covalently linked at respective first end units to a branched second core group C″, the chains P″ comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P′ by divalent linking groups L″, and c) at least one pendant cationic block copolymer chain A′-B′. A′-B′ comprises i) a divalent block A′ comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P′ by a divalent linking group L′, and ii) a monovalent block B′ comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.

  一种共价交联的水凝胶包括a) 三个或更多个二价聚(烷氧基烷氧基)链P′，其在各自的第一端单元上共价连接到分支的第一核心基团C′，b) 三个或更多个二价聚(烷氧基烷氧基)链P″，其在各自的第一端单元上与分支的第二核心基团C″共价连接，链P″包括通过二价连接基团L″与链P′的各自第二端单元之间共价连接到0%至100%的各自第二端单元的第二端单元，以及c) 至少一个挂链阳离子嵌段共聚物链A′-B′。A′-B′包括i) 一个二价块A′，包括一个与链P′中的一个链的第二端单元通过二价连接基团L′共价连接的聚(烷氧基烷氧基)骨架链，以及ii) 一个一价块B′，包括第一个重复单元，该第一个重复单元包括一个骨架碳酸酯基团和一个阳离子侧链基团。
• ALIMOV, EH.;ISKANDAROV, S. I., DOKL. AN UZSSR,(1988) N 2, 42-44
  作者：ALIMOV, EH.、ISKANDAROV, S. I.

  DOI：——

  日期：——