4-methoxy-2-nitrophenylhydrazine | 61690-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-2-nitrophenylhydrazine
• 英文别名: (4-Methoxy-2-nitrophenyl)hydrazine
• CAS: 61690-45-7
• 化学式: C₇H₉N₃O₃
• mdl: MFCD00460632
• 分子量: 183.167
• InChiKey: WMJOCGQUSXPCEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-methoxy-2-nitrophenylhydrazine 在 三乙胺 作用下， 以 xylene 为溶剂， 反应 3.0h， 以81%的产率得到1-Hydroxy-6-methoxy-benzotriazol
  参考文献：
  名称：

  Antiinflammatory and antinociceptive activities of some benzotriazolylalkanoic acids

  摘要：

  Sets of benzotriazol-1/2-ylalkanoic acids (1, 2, 3) and benzotriazol-1-yloxyalkanoic acids (4, 5) were prepared and tested for antiinflammatory activity; when significant activity was observed also the antinociceptive activity was explored. While the acids of structure 1, 4 and 5 were devoid of antiinflammatory action, most 2-(benzotriazol-1/2-yl)propionic acids (2, 3) exhibited significant activity as antiinflammatory and antinociceptive agents, with compound 2c and 3a being the most active in the two assays, respectively. The dextrorotatory enantiomer of 2c ((+)-2c) was also prepared and found to be practically as active as the racemic mixture, though some differences in the steepness of the dose-response curves were observed.

  DOI：

  10.1016/s0014-827x(02)00003-4
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 tin(ll) chloride 作用下， 生成 4-methoxy-2-nitrophenylhydrazine
  参考文献：
  名称：

  330.尝试寻找新的抗疟药。第十二部分。带有基本侧链的喹啉类的进一步变化

  摘要：

  DOI：

  10.1039/jr9340001524

文献信息

• A new redox-denitration reaction of aromatic nitro compounds
  作者：Charles W. Rees、Siu C. Tsoi

  DOI：10.1039/a910290f

  日期：——

  transformed into 4,4-dimethyl-1-phenylpyrazolidin-3,5-dione 10 in which the methylene group has been oxidised and the nitro group has disappeared; two further examples of the same reaction, of pyrazolidinones 4 and 7, are reported together with a mechanistic rationalisation of this curious reaction.

  当 4,4-二甲基-1-(2-硝基苯基)吡唑啉-3-酮 9 在含有吡啶盐酸盐的吡啶中加热时，它会转化为 4,4-二甲基-1-苯基吡唑啉-3,5-二酮 10，其中亚甲基被氧化，硝基消失；报告了吡唑烷酮 4 和 7 的相同反应的另外两个例子，以及这种奇怪反应的机械合理化。
• 2-Arylhydroxynitroindoles: A new procedure for the cleavage of aryl methyl ethers
  作者：G. V. Kokurkina、M. D. Dutov、S. A. Shevelev

  DOI：10.1002/jhet.769

  日期：2011.11

  A new procedure for the cleavage of aryl methyl ethers was developed. On this basis representatives of new types of 2‐arylhydroxynitroindoles were synthesized. J. Heterocyclic Chem., (2011).

  开发了裂解芳基甲基醚的新方法。在此基础上，合成了新型的2-芳基羟基硝基吲哚类化合物。J.杂环化​​学。（2011）。
• Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant
  作者：Cedric J. Stress、Pascal J. Schmidt、Dennis. G. Gillingham

  DOI：10.1039/c6ob00168h

  日期：——

  We use kinetic data, photophysical properties, and mechanistic analyses to compare recently developed high-rate constant oxime and hydrazone formations. We show that when Schiff base formation between aldehydes and arylhydrazines is carried out with an appropriately positioned boron atom, then aromatic B–N heterocycles form irreversibly. These consist of an extended aromatic structure amenable to the

  我们使用动力学数据，光物理性质和机理分析来比较最近开发的高速率恒定肟和的形成。我们显示，当醛和芳基肼之间的席夫碱形成是通过适当定位的硼原子进行的时，则芳香族B–N杂环不可逆地形成。这些由适合特定特性（例如反应速率和荧光）的扩展的芳族结构组成。该反应在中性水性缓冲液中效果最好，并且可以设计成具有荧光性的特性，这些特性在生物缀合中特别有趣。
• Indole derivatives. 126. Substituted nitrotryptamines
  作者：L. Kh. Vinograd、N. N. Suvorov

  DOI：10.1007/bf00506393

  日期：1984.9
• Boido; Vazzana; Sparatore, Il Farmaco, 1994, vol. 49, # 2, p. 97 - 104
  作者：Boido、Vazzana、Sparatore

  DOI：——

  日期：——