2-(4-Bromo-phenyl)-6-morpholin-4-yl-thiopyran-4-one | 500169-21-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(4-Bromo-phenyl)-6-morpholin-4-yl-thiopyran-4-one
• 英文别名: 2-(4-bromophenyl)-6-morpholin-4-ylthiopyran-4-one
• CAS: 500169-21-1
• 化学式: C₁₅H₁₄BrNO₂S
• 分子量: 352.252
• InChiKey: QZUNAXHRXHKZRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  485.7±45.0 °C(Predicted)
• 密度：
  1.547±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-Bromo-phenyl)-6-morpholin-4-yl-thiopyran-4-one 在 N-氯代丁二酰亚胺 作用下， 以 various solvent(s) 为溶剂， 反应 18.0h， 以39%的产率得到6-(4-bromophenyl)-3-chloro-2-morpholin-4-yl-4H-thiopyran-
  参考文献：
  名称：

  Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase

  摘要：

  Structure-activity relationships have been investigated for inhibition of DNA-dependent protein kinase (DNA-PK) and ATM kinase by a series of pyran-2-ones, pyran-4-ones, thiopyran-4-ones, and pyridin-4-ones. A wide range of IC50 values were observed for pyranones and thiopyranones substituted at the 6-position, with the 3- and 5-positions proving intolerant to substitution. Related pyran-2-ones, pyran-4-ones, and thiopyran-4-ones showed similar IC50 values against DNA-PK, whereas the pyridin-4-one system proved, in general, ineffective at inhibiting DNA-PK. Extended libraries exploring the 6-position of 2-morpholino-pyran-4-ones and 2-morpholino-thiopyrano-4-ones identified the first highly potent and selective ATM inhibitor 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (151C; ATM; IC50 = 13 nM) and revealed constrained SARs for ATM inhibition compared with DNA-PK. One of the most potent DNA-PK inhibitors identified, 2-(4-methoxyphenyl)-6-(morpholin-4-yl)pyran-4-one (16; DNA-PK; IC50 = 220 nM) effectively sensitized HeLa cells to the topoisomerase II inhibitor etoposide in vitro.

  DOI：

  10.1021/jm061121y
• 作为产物：
  描述：

  1-(4-Bromphenyl)-1,3-butandion (Enolform) 在 potassium carbonate 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙二醇 、 丙酮 为溶剂， 生成 2-(4-Bromo-phenyl)-6-morpholin-4-yl-thiopyran-4-one
  参考文献：
  名称：

  2,6-Disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK)

  摘要：

  6-Aryl-2-morpholin-4-yl-4H-pyran-4-ones and 6-aryl-2-morpholin-4-yl-4H-thiopyran-4-ones were synthesised and evaluated as potential inhibitors of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). Several compounds in each series exhibited superior activity to the chromenone LY294002, and were of comparable potency to the benzochromenone NU7026 (IC50=0.23 muM). Importantly, members of both structural classes were found to be selective inhibitors of DNA-PK over related phosphatidylinositol 3-kinase-related kinase (PIKK) family members. A multiple-parallel synthesis approach, employing Suzuki cross-coupling methodology, was utilised to prepare libraries of thiopyran-4-ones with a range of aromatic groups at the 3'- and 4'-positions on the thiopyran-4-one 6-aryl ring. Screening of the libraries resulted in the identification of 6-aryl-2-morpholin-4-yl-4H-thiopyran-4-ones bearing naphthyl or benzo[b]thienyl substituents at the 4'-position, as potent DNA-PK inhibitors with IC50 values in the 0.2-0.4 muM range. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00652-8

文献信息

• THIOPYRANE-4-ONES AS DNA PROTEIN KINASE INHIBITORS
  申请人：CANCER RESEARCH TECHNOLOGY LIMITED

  公开号：EP1416936B1

  公开（公告）日：2005-06-01