3,4-dicarboxybenzaldehyde | 144876-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dicarboxybenzaldehyde
• 英文别名: 1,2-Benzenedicarboxylic acid, 4-formyl-；4-formylphthalic acid
• CAS: 144876-16-4
• 化学式: C₉H₆O₅
• 分子量: 194.144
• InChiKey: PNODFDYINILVKZ-UHFFFAOYSA-N

物化性质

• 沸点：
  448.4±40.0 °C(Predicted)
• 密度：
  1.538±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,4-dicarboxybenzaldehyde 在 盐酸 作用下， 以 水 为溶剂， 生成 (RS)-3,4-二羧苯基甘氨酸
  参考文献：
  名称：

  Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes

  摘要：

  1 We investigated the agonist and atagonist activities of 22 new phenylglycine and phenylalamine derivatives for metabotropic glutamate receptors (mGluRs) by examining their effects on the signal transduction of mGluR(1), mGluR(2) and mGluR(6) subtypes expressed in Chinese hamster ovary cells. This analysis revealed several structural characteristics that govern receptor subtype specificity of the agonist and antagonist activities of phenylglycine derivatives.2 Hydroxyphenylglycine derivatives possessed either an agonist activity on mGluR(1) mGluR(6) or an antagonist activity on mGluR(1).3 Carboxyphenylglycine derivatives showed an agonist activity on mGluR(2) but an antagonist activity on mGluR(1).4 alpha-Methylation or alpha-ethylation of the carboxyphenylglycine derivatives converts the agonist property For mGluR(2) to an antagonist property, thus producing antagonists at both mGluR(1) and mGluR(2).5 Structurally-corresponding phenylalanine derivatives showed little or no agonist or antagonist activity on any subtypes of the receptors.6 This investigation demonstrates that the nature and positions of side chains and ring substituents incorporated into the phenylglycine structure are critical in determining the agonist and antagonist activities of members of this group of compounds on different subtypes of the mGluR family.7 We also tested two alpha-methyl derivatives of mGluR agonists. (2S, 1'S, 2'S)-2-(2-Carboxycyciopropyl)glycine (L-CCG-I) is a potent agonist for mGluR(2) but alpha-methylation of this compound changes its activity to that of an mGluR(2)-selective antagonist. In contrast, alpha-methylation of L-2-amino-4-phosphonobutyrate (L-AP4) results in retention of an agonist activity on mCluR(6). Thus, alpha-methylation produces different effects, depending on the chemical structures of lead compounds and/or on the subtype of mGluR tested.

  DOI：

  10.1111/j.1476-5381.1996.tb15312.x

文献信息

• Compositions for repelling crawling insects
  申请人：——

  公开号：US20020094993A1

  公开（公告）日：2002-07-18

  The present invention relates to novel compositions, comprising a repellent and an additive, where the additive is selected from the group consisting of phenol, benzaldehyde, benzoic acid or derivatives thereof and is present in a ratio of from 10:100 to 200:100% by weight to the repellent, and to their use for repelling crawling harmful insects, in particular ants or cockroaches.

  本发明涉及新型组合物，包括一种驱虫剂和一种添加剂，其中所述添加剂选自苯酚、苯甲醛、苯甲酸或其衍生物组成的群体，并以10:100至200:100％重量的比例存在于驱虫剂中，以及其用于驱赶爬行有害昆虫，特别是蚂蚁或蟑螂。
• Verfahren zur kontinuierlichen Herstellung von aromatischen Polykondensaten
  申请人：BASF Aktiengesellschaft

  公开号：EP0349773A2

  公开（公告）日：1990-01-10

  erfahren zur kontinuierlichen Herstellung von aromatischen Polykondensaten, aus a) aromatischen Hydroxy-, Thio- und/oder Aminocarbonsäuren, b) aromatischen Dihydroxy-, Dithio-, Diamino- und/oder Hydroxy-Aminoverbindungen, c) gegebenenfalls Harnstoff und d) einer Summe der Komponenten b) und c) äquivalenten molaren Menge an aromatischen Dicarbonsäuren, durch 1. Umsetzen der Komponenten a), b) und d) und gegebenenfalls c) mit niederen Fettsäureanhydriden im Überschuß, bei einer Temperatur von 140 bis 280 C unter Abdestillieren von Fettsäuren und Fettsäureanhydriden, 2. Leiten des Oligomerengemisches von oben nach unten durch eine senkrechte Präkondensationszone unter Bildung eines zweiphasigen Gemisches aus Präpolymeren und dampfförmigen Fettsäuren, 3. Trennen der Präpolymeren von den dampfförmigen Fettsäuren und 4. Kondensieren des Präpolymeren in einer Kondensationszone zu granulierfähigen Polykondensat.

  连续生产芳香族缩聚物的经验，从 a) 芳香族羟基、硫代和/或氨基甲酸酯、 b) 芳香族二羟基、二硫基、二氨基和/或羟基氨基化合物、 c) 可选的尿素和 d) 相等于 b) 和 c) 组分之和的芳香族二羧酸摩尔量，方法是 将 a)、b)、d)和 c)与过量的低级脂肪酸酐在 140 至 280 摄氏度的温度下反应，蒸馏出脂肪酸和脂肪酸酐、 2. 将低聚物混合物自上而下通过垂直预缩合区，形成预聚物和气相脂肪酸的两相混合物、 将预聚物与气相脂肪酸分离，以及 4. 在冷凝区冷凝预聚物，形成可造粒的缩聚物。
• NOVEL ANTHRAPYRIDONE COMPOUNDS, WATER-BASED MAGENTA INK COMPOSITION, AND METHOD OF INK-JET RECORDING
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP1067155A1

  公开（公告）日：2001-01-10

  The present invention provides novel anthrapyridone compounds or salts thereof which have a magenta hue and vividness suitable for ink-jet recording and give the recorded material having a high fastness in light fastness and water fastness. That is, the present invention relates to an anthrapyridone compound represented by Formula A-B or the salt thereof, wherein A is the dyestuff residue represented by Formula (1)    (in the formula, R1 is hydrogen atom or an alkoxycarbonyl group and R2 is hydrogen atom or methyl group); and B is hydrogen atom or a substituent group on the dyestuff residue A, a water-based magenta ink composition which includes the said compound and an ink-jet recording method which uses the said compound.

  本发明提供了新型蒽吡啶酮化合物或其盐，它们具有适合喷墨记录的洋红色色调和鲜艳度，并使记录材料具有很高的耐光牢度和耐水性。 也就是说，本发明涉及一种由式 A-B 表示的蒽吡啶酮化合物或其盐，其中 A 是由式（1）表示的染料残留物 (式中，R1 为氢原子或烷氧基羰基，R2 为氢原子或甲基）；B 为氢原子或染料残基 A 上的取代基；一种包含上述化合物的水性洋红色墨水组合物和一种使用上述化合物的喷墨记录方法。
• Kozlov; Popova, Russian Journal of Organic Chemistry, 1999, vol. 35, # 4, p. 603 - 605
  作者：Kozlov、Popova

  DOI：——

  日期：——
• ANTHRAPYRIDONE COMPOUNDS, WATER-BASED MAGENTA INK COMPOSITION, AND METHOD OF INK-JET RECORDING
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP1067155B1

  公开（公告）日：2008-02-27