5-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxy-benzoic acid | 915282-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 5-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxy-benzoic acid
• 英文别名: 5-([(9H-Fluoren-9-ylmethoxy)carbonyl]amino)-2-hydroxybenzoic acid；5-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybenzoic acid
• CAS: 915282-95-0
• 化学式: C₂₂H₁₇NO₅
• 分子量: 375.381
• InChiKey: CZJOWGTWDFUJBH-UHFFFAOYSA-N

物化性质

• 沸点：
  572.1±50.0 °C(Predicted)
• 密度：
  1.420±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxy-benzoic acid 在 4-二甲氨基吡啶 、 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 4.5h， 生成 9H-fluoren-9-ylmethyl N-[3-(5-chloro-4-nitroimidazole-1-carbonyl)-4-hydroxyphenyl]carbamate
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
  [FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE MALADIES AUTOIMMUNES

  摘要：

  公开号：

  WO2014068506A3
• 作为产物：
  描述：

  5-氨基水杨酸 、 氯甲酸-9-芴基甲酯 以 二氯甲烷 为溶剂， 生成 5-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxy-benzoic acid
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
  [FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE MALADIES AUTOIMMUNES

  摘要：

  公开号：

  WO2014068506A3

文献信息

• Derivatives of 4- or 5-aminosalicylic acid
  申请人：Wallace L. John

  公开号：US20060270635A1

  公开（公告）日：2006-11-30

  The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

  本发明提供了4-或5-氨基水杨酸的新衍生物，以及含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，用于治疗肠病，如炎症性肠病（IBD）和肠易激综合症（IBS）以及预防/治疗结肠癌。更具体地，这些衍生物包含一个通过偶氮基、酯基、酐基、硫酯基或酰胺键连接到4-或5-氨基水杨酸分子上的硫化氢释放基团。此外，本发明还提供了制备这些化合物的方法以及它们用于治疗IBD和IBS以及预防/治疗结肠癌的应用。
• Derivaitves of 4-Or 5-Aminosalicylic Acid
  申请人：Wallace John L.

  公开号：US20080207564A1

  公开（公告）日：2008-08-28

  The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

  本发明提供了4-或5-氨基水杨酸的新衍生物，以及含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，用于治疗肠道疾病，如炎症性肠病（IBD）和肠易激综合征（IBS），以及预防/治疗结肠癌。更具体地说，这些衍生物包括通过偶氮键，酯键，酸酐键，硫酯键或酰胺键连接到4-或5-氨基水杨酸分子的硫化氢释放基团。此外，本发明提供了制备这些化合物的方法以及它们用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
• DERIVATIVES OF 4- OR 5-AMINOSALICYLIC ACID
  申请人：Wallace John L.

  公开号：US20090233886A1

  公开（公告）日：2009-09-17

  The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

  本发明提供了4-或5-氨基水杨酸的新衍生物，以及包含这些4-或5-氨基水杨酸衍生物作为活性成分的制药组合物，用于治疗肠道疾病，如炎症性肠病（IBD）和肠易激综合征（IBS），以及预防/治疗结肠癌。更具体地说，这些衍生物包括通过偶氮，酯，酸酐，硫酯或酰胺连接到4-或5-氨基水杨酸分子上的释放硫化氢的基团。此外，本发明提供了一种制备这些化合物的方法以及它们用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
• Human testis expressed patched like protein
  申请人：Aeomica, Inc.

  公开号：EP1229046A2

  公开（公告）日：2002-08-07

  The invention provides isolated nucleic acids that encode HTPL, including two isoforms, and fragments thereof, vectors for propagating and expressing HTPL nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel HTPL isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human HTPL nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human HTPL gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the HTPL nucleic acids, proteins, and antibodies of the present invention.

  本发明提供了编码 HTPL（包括两种异构体）的分离核酸及其片段、繁殖和表达 HTPL 核酸的载体、包含本发明核酸和载体的宿主细胞、新型 HTPL 异构体的蛋白质、蛋白质片段和蛋白质融合体及其抗体。本发明进一步提供了包含人类 HTPL 核酸的转基因细胞和非人类生物体，以及靶向干扰人类 HTPL 基因内源直向同源物的转基因细胞和非人类生物体。本发明进一步提供了本发明核酸、蛋白质和抗体的药物制剂，以及基于本发明 HTPL 核酸、蛋白质和抗体的诊断、研究和治疗方法。
• A human protein kinase domain-containing protein
  申请人：Aeomica, Inc.

  公开号：EP1227156A2

  公开（公告）日：2002-07-31

  The invention provides isolated nucleic acids that encode a human protein kinase domain-containing portein (STTK), and fragments thereof, vectors for propagating and expressing STTK nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel STTK isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising STTK nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the STTK gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the STTK nucleic acids, proteins, and antibodies of the present invention.

  本发明提供了编码含人蛋白激酶结构域的门冬氨酸（STTK）的分离核酸及其片段、用于繁殖和表达STTK核酸的载体、包含本发明核酸和载体的宿主细胞、新型STTK异构体的蛋白质、蛋白质片段和蛋白质融合体及其抗体。本发明进一步提供了包含 STTK 核酸的转基因细胞和非人类生物体，以及定向破坏 STTK 基因内源直向同源物的转基因细胞和非人类生物体。本发明进一步提供了本发明核酸、蛋白质和抗体的药物制剂，以及基于本发明 STTK 核酸、蛋白质和抗体的诊断、研究和治疗方法。