己烯雌酚频哪醇酮 | 18922-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 己烯雌酚频哪醇酮
• 英文名称: diethylstilbesterol pinacolone
• 英文别名: diethylstilbestrol pinacolone；4,4-Bis-(4-hydroxy-phenyl)-hexanon-(3)；4,4-bis-(4-hydroxy-phenyl)-hexan-3-one；4,4-Bis-(4-hydroxy-phenyl)-hexan-3-on；4,4-bis(4-hydroxyphenyl)hexan-3-one
• CAS: 18922-13-9
• 化学式: C₁₈H₂₀O₃
• 分子量: 284.355
• InChiKey: VXQMNZNWFJLHAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2914501900

反应信息

• 作为反应物：
  描述：

  己烯雌酚频哪醇酮 在 盐酸 、 sodium tetrahydroborate 、 calcium chloride 作用下， 以 异丙醇 为溶剂， 反应 16.0h， 生成 顺式己烯雌酚
  参考文献：
  名称：

  Improved method for the preparation of diethylstilbestrol from 4,4-bis(p-acetoxyphenyl)-3-hexanone

  摘要：

  DOI：

  10.1007/bf00780182
• 作为产物：
  描述：

  racem.-3.4-bis-(4-hydroxy-phenyl)-hexanediol-(3.4) 在 potassium pyrosulfate 作用下， 生成 己烯雌酚频哪醇酮
  参考文献：
  名称：

  v. Wessely et al., Monatshefte fur Chemie, 1941, vol. 73, p. 127,158

  摘要：

  DOI：

文献信息

• Effect of Low-Fat and/or Low-Energy Diets on Anthropometric Measures in Participants of the Women’s Diet Study
  作者：Zora Djuric、Samir Lababidi、Lance K. Heilbrun、Janice B. Depper、Kathleen M. Poore、Virginia E. Uhley

  DOI：10.1080/07315724.2002.10719192

  日期：2002.2

  Objective: To compare the effects of low-fat, low-energy and combination low-fat/low-energy intervention on changes in six anthropometric measures in Caucasian and African-American free-living women.Methods: The effects of dietary counseling strategies for fat and/or energy reduction were examined on anthropometric measures in 86 pre-menopausal women, average BMI of 28 kg/m(2), who participated in a 12-week intervention trial called the Women's Diet Study. The dietary goals were 1510 of energy from fat and/or 25% reduction in energy intake, relative to reported baseline intake, using a 2 x 2 factorial design. Analysis of covariance models were constructed to evaluate changes in anthropometric measures over the 12 weeks of study.Results: The biggest difference by race was in women who were relatively heavier at baseline, in which case African-American women lost significantly less weight but decreased their waist:hip ratio to a significantly greater extent than Caucasian women. With regard to the effects of diet arm, weight loss varied depending on baseline weight, and in women with higher baseline weights, the combination low-fat/low-energy diet resulted in the most weight loss (6.7 kg, p < 0.05). Decreases in the other anthropometric measures at week 12 were more uniform across diet arms and did not depend on baseline values. After controlling for previous weight history and race, the decreases in BMI, percent body fat and waist circumference after 12 weeks were statistically equivalent with the low-fat, low-energy or combination low-fat/low-energy diets. The relatively greater decreases in percent body fat and waist circumference with the combination diet versus the low-fat or low-energy diets were not statistically significant.Conclusion: The low-fat, low-energy and combination diets all resulted in similar and statistically significant decreases in BMI, percent body fat and waist circumference over 12 weeks of intervention. The extent of weight loss, however, varied depending on baseline weight, and the combination diet was the only intervention to result in significant weight loss for women who were heavier at baseline. This indicates that, although there may be an advantage for reducing dietary fat in initially heavier women, any of these counseling strategies could be effective for improving anthropometric predictors of health risks associated with overweight status. This is useful since flexibility in dietary choices may facilitate adherence to dietary counseling in some individuals.
• Oda, Taiko; Watanuki, Mitsuru; Sato, Yoshihiro, Chemical and pharmaceutical bulletin, 1993, vol. 41, # 5, p. 810 - 815
  作者：Oda, Taiko、Watanuki, Mitsuru、Sato, Yoshihiro、Hata, Tadashi

  DOI：——

  日期：——
• The Preparation of Synthetic Estrogens. V.¹ New Routes to 3,3-Bis-(p-hydroxyphenyl)-4-hexanone and the Allied Substances
  作者：Keiiti Sisido、Hitosi Nozaki、Osamu Kurihara

  DOI：10.1021/ja01161a110

  日期：1950.5
• Adler; Lundin, Arkiv foer Kemi, 1945, vol. 19 A, # 24, p. 3,7
  作者：Adler、Lundin

  DOI：——

  日期：——
• Process for the manufacture of compounds of alpha, beta-(rho, rho'-dihydroxydiaryl)-alpha, beta-dialkyl-alkyl and -alkylene
  申请人：HOFFMANN LA ROCHE

  公开号：US02421401A1

  公开（公告）日：1947-06-03