2,6-diisopropyl-4-methoxyphenol | 1988-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-diisopropyl-4-methoxyphenol
• 英文别名: 4-methoxy-2,6-di(propan-2-yl)phenol
• CAS: 1988-09-6
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: RXUVSUWTUYNHFP-UHFFFAOYSA-N

物化性质

• 熔点：
  47.5-48.5 °C(Solv: heptane (142-82-5))
• 沸点：
  171-173 °C(Press: 30 Torr)
• 密度：
  0.982±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-diisopropyl-4-methoxyphenol 、 5,6-二氯-2,3-二氰基吡嗪 在 cesium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以80%的产率得到5,6-bis(2,6-diisopropyl-4-methoxyphenoxy)pyrazine-2,3-dicarbonitrile
  参考文献：
  名称：

  New highly soluble phenoxy-substituted phthalocyanine and azaphthalocyanine derivatives: Synthesis, photochemical and photophysical studies and atypical aggregation behavior

  摘要：

  A series of zinc phthalocyanines and corresponding aza-analogues azaphthalocyanines substituted with peripheral 2,6-diisopropylphenoxy substituents containing different functional groups (Br, OCH3, and OH) were synthesized and their photophysical properties were investigated. UV-vis and H-1 NMR analyses confirmed the non-aggregation behavior of the prepared complexes in most organic solvents. All investigated compounds showed good photophysical and photochemical properties in THF and DMF with Phi(F) values in the range of 0.22-0.44 and Phi(Delta) values ranging between 0.42 and 0.57. Hydroxylated compounds showed good solubility in polar solvents including ethanol, methanol, acetone and even in aqueous ethanol mixtures. Absorption spectra in aqueous ethanol indicated presence of only monomers even at very low ethanol content in water (0.5% of ethanol in water). Despite this, no fluorescence occurred from approximately 50% of ethanol in water suggesting presence of aggregates that do not differ from monomers in a shape of absorption spectra. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2012.03.023
• 作为产物：
  描述：

  丙泊酚 在 sodium hydroxide 作用下， 以 苯 为溶剂， 生成 2,6-diisopropyl-4-methoxyphenol
  参考文献：
  名称：

  Petranek,J.; Pilar,J., Collection of Czechoslovak Chemical Communications, 1970, vol. 35, p. 830 - 837

  摘要：

  DOI：

文献信息

• Inhibitors of Acyl-CoA:Cholesterol <i>O</i>-Acyltransferase. 17. Structure−Activity Relationships of Several Series of Compounds Derived from <i>N</i>-Chlorosulfonyl Isocyanate
  作者：Joseph A. Picard、Patrick M. O'Brien、Drago R. Sliskovic、Maureen K. Anderson、Richard F. Bousley、Katherine L. Hamelehle、Brian R. Krause、Richard L. Stanfield

  DOI：10.1021/jm9509455

  日期：1996.3.15

  Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3-44 were the most potent inhibitors in vitro, with several compounds having IC50 values < 1 microM. Although the other series of compounds were not as potent in vitro, many compounds did display

  通过将氮，氧和硫亲核试剂逐步添加到N-氯磺酰基异氰酸酯中，可以制备几种系列的酰基CoA：胆固醇O-酰基转移酶抑制剂。（氨基磺酰基）脲3-44是体外最有效的抑制剂，几种化合物的IC50值<1 microM。尽管其他系列的化合物在体外效果不佳，但许多化合物在以胆固醇喂养的大鼠中确实显示出良好的体内活性。几种氧磺酰基氨基甲酸酯（包括CI-999、115）在慢性体内筛选中显示出出色的降脂活性，表明在预先建立的高胆固醇血症状态下胆固醇显着降低。
• Beyond DPPH: Use of Fluorescence-Enabled Inhibited Autoxidation to Predict Oxidative Cell Death Rescue
  作者：Ron Shah、Luke A. Farmer、Omkar Zilka、Antonius T.M. Van Kessel、Derek A. Pratt

  DOI：10.1016/j.chembiol.2019.09.007

  日期：2019.11

  as inhibitors of ferroptosis, the oxidative cell death modality associated with (phospho)lipid peroxidation. We subsequently describe our efforts to develop an approach that quantifies the reactivity of putative antioxidants with the (phospho)lipid peroxyl radicals that propagate (phospho)lipid peroxidation (dubbed FENIX [fluorescence-enabled inhibited autoxidation]). The results obtained with FENIX

  “抗氧化剂活性”是经常被调用的但通常表征不佳的分子性质。有几种测定方法可用于确定抗氧化剂的活性，其中最流行的是基于假定的抗氧化剂还原2，2-二苯基-1-吡啶并肼基的能力。在这里，我们表明该测定的结果与推定的抗氧化剂作为ferroptosis抑制剂（与（磷脂）脂质过氧化有关的氧化性细胞死亡方式）的效力不相关。随后，我们描述了我们的工作，以开发一种方法，该方法可量化假定的抗氧化剂与传播（磷酸）脂质过氧化的（磷酸）脂质过氧化自由基（称为FENIX [荧光激活的抑制性自氧化]）的反应性。
• Bismuth Aryloxides
  作者：Xiaodi Kou、Xiaoyu Wang、Daniel Mendoza-Espinosa、Lev N. Zakharov、Arnold L. Rheingold、William H. Watson、Kimberly A. Brien、L. Kasun Jayarathna、Tracy A. Hanna

  DOI：10.1021/ic901134t

  日期：2009.12.7

  elemental analysis) of 13 bismuth aryloxides are reported. We have prepared bismuth aryloxides with alkyl, aryl, and allylic substituents on the aryl rings. Eleven of these bismuth aryloxides have been characterized with single crystal X-ray diffraction methods. Bismuth−donor interactions (donor = aryl, methoxy) are observed in several cases. Three unexpected bismuth oxo aryloxides (6c, 9c, 11c) were

  报告了13种芳基氧化铋的合成和完整表征（mp，NMR，UV / vis，FTIR和元素分析）。我们已经制备了芳基环上具有烷基，芳基和烯丙基取代基的芳基氧化铋。这些铋芳基氧化物中的十一种已通过单晶X射线衍射法进行了表征。在几种情况下观察到铋-供体相互作用（供体=芳基，甲氧基）。还分离出了三个意外的羰基氧化铋氧化铋（6c，9c，11c）。配合物C 77 H 102 Bi 4 Br 6 O 8（6c）是由于在Bi（O-2,6- i Pr 2 -4-BrC 6 H 2）3（6）的合成中作为副产物出现了明显的CH活化和Bi-C键形成。团簇9c具有Bi 32 O 56核，而团簇C 90 H 90 Bi 4 Li 2 O 12（11c）是迄今为止报道的第二个锂铋氧簇。
• POLYMERIZABLE COMPOSITION, THERMOPLASTIC RESIN COMPOSITION, CROSSLINKED RESIN, AND CROSSLINKED RESIN COMPOSITE MATERIALS
  申请人：ZEON CORPORATION

  公开号：EP1589054A1

  公开（公告）日：2005-10-26

  A polymerizable composition which comprises (i) a cycloolefin monomer, (ii) a metathesis polymerization catalyst, (iii) a chain transfer agent, (iv) a radical crosslinking agent, and (v) a compound (α) selected from the group consisting of compounds having alkoxyphenol structures wherein each aromatic ring has one or more substituents, compounds having aryloxyphenol structures, and compounds having catechol structures wherein each aromatic ring has two or more substituents; a thermoplastic resin composition which comprises (1) a cycloolefin thermoplastic resin, (2) a radical crosslinking agent, and (3) a compound (α) ; a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials produced by laminating a substrate with the thermoplastic resin composition and crosslinking the thermoplastic resin composition. The invention provides a polymerizable composition useful as raw material in the production of a thermoplastic resin composition excellent in storage stability and fluidity in heat lamination; a thermoplastic resin composition and a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials exhibiting excellent interlayer adhesion.

  一种可聚合组合物，它包括(i)环烯烃单体，(ii)偏聚催化剂，(iii)链转移剂，(iv)自由基交联剂，和(v)选自以下组别的化合物(α)：具有烷氧基苯酚结构的化合物，其中每个芳香环有一个或多个取代基；具有芳氧基苯酚结构的化合物；以及具有邻苯二酚结构的化合物，其中每个芳香环有两个或多个取代基；一种热塑性树脂组合物，它包括：(1) 环烯烃热塑性树脂；(2) 自由基交联剂；(3) 化合物 (α)；其生产工艺；通过交联该热塑性树脂组合物而获得的交联树脂；以及通过将基材与该热塑性树脂组合物层压并交联该热塑性树脂组合物而生产的交联树脂复合材料。本发明提供了一种可聚合组合物，可作为生产热塑性树脂组合物的原料，该组合物具有优异的储存稳定性和热层压流动性；一种热塑性树脂组合物及其生产工艺；一种通过交联该热塑性树脂组合物而获得的交联树脂；以及具有优异层间粘合性的交联树脂复合材料。
• A process for the stereospecific polymerization of an alpha-olefin and an alpha-olefin polymerization catalyst system
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0021478B1

  公开（公告）日：1985-07-17