1-(-)-2-氨基-1-丁醇 | 40898-95-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-(-)-2-氨基-1-丁醇
• 英文名称: 2-amino-1-butanol
• 英文别名: 1-(-)-2-amino-1-butanol；1-Aminobutan-1-ol
• CAS: 40898-95-1
• 化学式: C₄H₁₁NO
• 分子量: 89.1374
• InChiKey: OZHIYEINSCNALY-UHFFFAOYSA-N

物化性质

• 沸点：
  142.3±23.0 °C(Predicted)
• 密度：
  0.927±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  O,O,O-三甲基巯基磷酸酯 、 1-(-)-2-氨基-1-丁醇 以 苯 为溶剂， 生成 Methyl-<1-hydroxy-butyl-2>-amin
  参考文献：
  名称：

  Shvetsova-Shilovskaya,K.D. et al., Journal of general chemistry of the USSR, 1964, vol. 34, p. 2150 - 2152

  摘要：

  DOI：
• 作为产物：
  描述：

  正丁醛 在 ammonium hydroxide 作用下， 生成 1-(-)-2-氨基-1-丁醇
  参考文献：
  名称：

  Structure and chemistry of the aldehyde ammonias. 1-Amino-1-alkanols, 2,4,6-trialkyl-1,3,5-hexahydrotriazines, and N,N-dialkylidene-1,1-diaminoalkanes

  摘要：

  DOI：

  10.1021/jo00959a010

文献信息

• Androgen receptor modulator compounds and methods
  申请人：Ligand Pharmaceuticals, Inc.

  公开号：US06462038B1

  公开（公告）日：2002-10-08

  Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.

  化合物、药物组合物和调节类固醇受体介导过程的方法。具体描述了非类固醇化合物和组合物的制备和使用方法，这些化合物和组合物是雄激素受体（AR）的激动剂、部分激动剂和拮抗剂。此外，还描述了制备和使用关键中间体的方法，包括用于AR调节剂的立体选择性合成路线。
• N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives
  申请人：——

  公开号：US20030236256A1

  公开（公告）日：2003-12-25

  The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria and viruses, or combinations of two or more of these organisms, by applying at least one compound of the formula (I): wherein n is 0 or 1, R 1 is halogen, alkoxy, haloalkyl, haloalkoxy or alkyl, R 2 is hydrogen, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, each of R 3 , R 4 and R 5 is, independently of the others, hydrogen, lower alkyl or halogen, and R 6 is as defined in claim 1. The invention also relates to new compounds of formula (I), their preparation, use and compositions comprising said compound.

  本发明涉及一种保护植物免受植物病原体，如线虫或特别是微生物，优选为真菌、细菌和病毒，或两种或两种以上这些生物的攻击或感染的方法，通过施用至少一种化合物的公式（I）：其中n为0或1，R1为卤素、烷氧基、卤代烷基、卤代烷氧基或烷基，R2为氢、卤素、烷基、卤代烷基、烷氧基或卤代烷氧基，R3、R4和R5中的每一个独立地为氢、较低烷基或卤素，R6如权利要求1所定义。本发明还涉及公式（I）的新化合物、其制备、使用以及包含所述化合物的组合物。
• Ornithine decarboxylase inhibiting branched aminooxy amino alkane
  申请人：Ciba-Geigy Corporation

  公开号：US05610195A1

  公开（公告）日：1997-03-11

  Compounds of formula (I) in which (a) four of the radicals R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen and the others independently of one another are in each case C.sub.1 -C.sub.2 alkyl, these groups being bonded to the same carbon atom or to two different carbon atoms, or (b) five of the radicals R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen and the other radical is C.sub.1 -C.sub.2 alkyl or hydroxymethyl, or salts thereof, are described. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.

  化学式（I）中的化合物，其中（a）R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5和R.sub.6中的四个基团为氢，其余基团独立地分别为每种情况下为C.sub.1-C.sub.2烷基，这些基团与同一碳原子或两个不同的碳原子结合，或者（b）R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5和R.sub.6中的五个基团为氢，另一个基团为C.sub.1-C.sub.2烷基或羟甲基，或其盐。这些化合物的化学式（I）及其盐是鸟氨酸脱羧酶抑制剂。
• p-Aminobenzoate Organic Salts as Potential Plant Growth Regulators for Tomatoes
  作者：Radu-Liviu Sumalan、Lilia Croitor、Mihaela Petric、Isidora Radulov、Paulina Bourosh、Renata-Maria Sumalan、Manuela Crisan

  DOI：10.3390/molecules25071635

  日期：——

  The discovery of environmentally friendly and inexpensive plant growth regulators (PGRs) for agronomically important crops is a necessity and must be considered a priority worldwide. This study provides the synthesis, structure determination and the biological evaluation of two binary organic salts as potential PGRs. New compounds have dual biological activity and are based on natural metabolite p-aminobenzoic

  为具有重要农艺意义的作物发现环境友好且价格低廉的植物生长调节剂 (PGR) 是必要的，并且必须被全世界视为优先事项。本研究提供了作为潜在 PGR 的两种二元有机盐的合成、结构测定和生物学评价。新化合物具有双重生物活性，基于天然代谢物对氨基苯甲酸 (pABAH) 和不同的链烷醇胺。由于形成了一个同合成子和各种异合成子，所研究的化合物表现出具有不同晶体堆积的氢键 3D 超分子结构。在实验室和温室中对茄属植物进行了新化合物的生物学研究，揭示了其促进植物生根和植物生产力的效率。
• Nitrosated and nitrosylated diuretic compounds, compositions and methods of use
  申请人：Garvey S. David

  公开号：US20050059655A1

  公开（公告）日：2005-03-17

  The invention describes novel nitrosated and/or nitrosylated diuretic compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated diuretic compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one diuretic compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; and (l) treating nephropathy.

  本发明描述了新型的硝酸化和/或亚硝酸化利尿化合物或其药学上可接受的盐，并且描述了至少包含一种硝酸化和/或亚硝酸化利尿化合物的新型组合物，以及可选地，至少包含一种一氧化氮供体和/或至少一种治疗剂的新型组合物。本发明还提供了包含本发明中的至少一种利尿化合物的新型组合物和套装，该利尿化合物可选择硝酸化和/或亚硝酸化，可选地包含至少一种一氧化氮供体化合物和/或至少一种治疗剂。本发明还提供了治疗以下病症的方法：(a)治疗由过多水和/或电解质滞留引起的病症；(b)治疗心血管疾病；(c)治疗肾血管疾病；(d)治疗糖尿病；(e)治疗由氧化应激引起的疾病；(f)治疗内皮功能障碍；(g)治疗由内皮功能障碍引起的疾病；(h)治疗肝硬化；(j)治疗先兆子痫；(k)治疗骨质疏松症；以及(l)治疗肾病。