O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate | 85344-81-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
• 英文别名: fenitrothion；S-Arylfenitrothion；O,O-dimethyl S-3 methyl-4-nitrophenyl phosphorothioate；4-dimethoxyphosphorylsulfanyl-2-methyl-1-nitrobenzene
• CAS: 85344-81-6
• 化学式: C₉H₁₂NO₅PS
• 分子量: 277.238
• InChiKey: NUPBIXYCTGWWKZ-UHFFFAOYSA-N

物化性质

• 沸点：
  382.5±52.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甲醇 、 O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate 在 四丁基氢氧化铵 sodium methylate 、 zinc trifluoromethanesulfonate 、 1,5,9-三氮杂环十二烷 作用下， 生成 磷酸三甲酯 、 3-甲基-4-硝基苯硫醇
  参考文献：
  名称：

  三氮杂十二烷：Zn（2 +）-甲醇配合物催化的中性C = O，P = O和P = S酯的甲醇解的溶剂氘动力学同位素效应。

  摘要：

  反向的k（D）/ k（H）值与直接亲核甲醇盐攻击有关，后者涉及亲核试剂的去溶剂化以及TS溶解程度不同。使用Zn（2 +）（（-）OCH（3））络合物时，所有天空值均为k（D）/ k（H）= 1.0 +/- 0.1，除非该值为0.79 +/- 0.06。提出了与复合物相关的分馏因子：Zn（2 +）（（-）OCH（3））与单位的区别。所有复合物催化的甲醇酶的天空都被解释为与平衡前金属：底物复合物中Zn（2+）配位的甲醇盐的分子内亲核攻击相一致。1，除了值是0.79 +/- 0.06之外。提出了与复合物相关的分馏因子：Zn（2 +）（（-）OCH（3））与单位的区别。所有复合物催化的甲醇酶的天空都被解释为与平衡前金属：底物复合物中Zn（2+）配位的甲醇盐的分子内亲核攻击相一致。1，除了值是0.79 +/- 0.06之外。提出了与复合物相关的分馏因子：Zn（2 +）（（-）OCH（3））与单位的区

  DOI：

  10.1039/b512378j

文献信息

• An insecticidal and miticidal composition which contains a carbamate and an organic phosphorus compound, and a method of controlling insects and mites therewith
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0017738A1

  公开（公告）日：1980-10-29

  An insecticidal and miticidal composition in which 2-dimethylamino-5,6-dimethylpyrimidin-4-yl dimethylcarbamate and at least one organic phosphorus compound, methylcarbamate compound, or pyrethroid compound are mixed with an inert carrier.

  一种杀虫和杀螨剂组合物，其中 2-二甲基氨基-5,6-二甲基嘧啶-4-基二甲基氨基甲酸酯和至少一种有机磷化合物、甲基氨基甲酸酯化合物或拟除虫菊酯化合物与惰性载体混合。
• Method for preparation of a shaped chitin body containing a physiologically active substance
  申请人：UNITIKA LTD.

  公开号：EP0159139A2

  公开（公告）日：1985-10-23

  A shaped chitin body containing a high content of a physiologically active substance, such as a drug to be used for the cure or prevention of disease, is prepared by incorporating said physiologically active substance into a dope comprising (a) a water-insoluble chitin, (b) lithium chloride, and (c) N-methylpyrrolidone and/or dimethylacetamide, with the amount of said physiologically active substance incorporated being 0.5 wt. % or more with respect to the amount of the chitin contained in said dope, and there after coagulating the resulting mixture with a coagulant to obtain a shaped body. The high content of the physiologically active substance thus incorporated in the shaped chitin can be slowly released therefrom over a long period of time. The shaped-chitin of the present invention is characterized by long duration of the physiological activity of the active substance contained therein.

  一种含有高含量生理活性物质（如用于治疗或预防疾病的药物）的成型甲壳素体的制备方法是，将所述生理活性物质加入由以下成分组成的涂料中：(a) 水不溶性甲壳素、(b) 氯化锂和 (c) N-甲基吡咯烷酮和/或二甲基乙酰胺，其中所述生理活性物质的加入量为所述涂料中所含甲壳素量的 0.5 wt. % 或更多，然后用凝固剂将所得混合物凝固，得到成型体。 这样在成型甲壳素中加入的高含量生理活性物质可以在很长一段时间内从其中缓慢释放出来。本发明的异型甲壳素的特点是其中所含活性物质的生理活性持续时间长。
• An agricultural composition with reduced toxicity to fishes and shellfishes
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0189377A2

  公开（公告）日：1986-07-30

  Agricultural formulation with reduced toxicity to fishes and shelifishes, characterized by comprising a lipophilic agriculturally active ingredient (I) and an organic compound (II) having a partition coefficient to the said compound (I) in water of no less than 102 and a process for the production of the said formulation.

  一种对鱼类和遮目鱼毒性降低的农用制剂，其特征在于包含一种亲脂性农用活性成分（I）和一种有机化合物（II），其与上述化合物（I）在水中的分配系数不低于 102，以及一种生产上述制剂的工艺。
• A process for the production of a granule-shaped composition comprising agricultural chemical compound
  申请人：MEIJI SEIKA KAISHA LTD.

  公开号：EP0255760A1

  公开（公告）日：1988-02-10

  A granule-shaped composition containing an agri­cultural chemical compound and a high proportion of an anionic surface-active agent of selected types in an effective amount to enhance the useful biological activity of said agricultural chemical compound may readily be produced by a process wherein a concentrated aqueous solution or slurry containing said agricultural chemical compound and the anionic surface-active agent at selected ratios, as well as one or more optional additives such as a solid vehicle or water-soluble extender is atomized by means of a spray nozzle of specified outlet orifice diameter and is spray-dried in a spray-drying tower chamber according to a counter-current flow spray-drying method in a specially stipulated manner and under specially selected conditions of operation. The granule-shaped composition so produced has a substantially hollow space within each substantially spherical granule and shows high free-­flowing property, favorable collapsibility or dis­integrability into water, and favorable solubility or dispersibility in water.

  一种颗粒状组合物含有农用化学化合物和高比例的所选类型的阴离子表面活性剂，其有效量可提高所述农用化学化合物的有用生物活性、以及一种或多种可选添加剂（如固体载体或水溶性扩展剂）的浓缩水溶液或浆液，通过指定出口孔径的喷嘴雾化，并按照逆流喷雾干燥法在喷雾干燥塔室中以特别规定的方式和特别选定的操作条件进行喷雾干燥。这样制得的颗粒状组合物在每个基本球形的颗粒内都有一个基本中空的空间，并显示出高度的自由流动性、良好的可塌陷性或水分解性，以及良好的水溶性或分散性。
• Stabilized solid composition
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0280289A2

  公开（公告）日：1988-08-31

  This invention relates to a stabilized solid com­position which comprises S,Sʹ-[2-(dimethylamino)tri­methylene] bis-benzenethiosulfonate and at least one oxide compound selected from the calss consisting of titanium dioxide, calcium oxide, zinc oxide, magnesium oxide and boron oxide, and this invention also relates to a method for the production of the above-mentioned solid composition. The composition according to the present invention is used as an insecticide for agricultural use.

  本发明涉及一种稳定的固体组合物，它包括 S,Sʹ-[2-(二甲基氨基)三亚甲基] 双苯硫代磺酸盐和至少一种选自二氧化钛、氧化钙、氧化锌、氧化镁和氧化硼的氧化物化合物，本发明还涉及生产上述固体组合物的方法。 根据本发明的组合物可用作农用杀虫剂。