5,6-dihydro-1,3-dimethyl-5-phenyl pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5,6-dihydro-1,3-dimethyl-5-phenyl pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione
• 英文别名: 1,3-dimethyl-5-phenyl-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione；1,3-dimethyl-5-phenyl-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,6H)-trione；7-hydroxy-1,3-dimethyl-5-phenyl-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione；1,3-dimethyl-5-phenyl-6,8-dihydro-5H-pyrimido[4,5-d]pyrimidine-2,4,7-trione
• 化学式: C₁₄H₁₄N₄O₃
• 分子量: 286.29
• InChiKey: YWBVMJUWANWVCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-amino-5-[6'-amino-1',3'-dimethyl-2',4'-dioxo-1',2',3',4'-tetrahydro-5'-pyrimidinyl(phenyl)methyl]-1,3-dimethyl-1,2,3,4-tetrahydro-2,4-pyrimidinedione 、 N-甲基脲 在 溶剂黄146 作用下， 反应 0.08h， 以89%的产率得到5,6-dihydro-1,3-dimethyl-5-phenyl pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione
  参考文献：
  名称：

  一种新型高效合成嘧啶[4,5- d ]嘧啶-2,4,7-三酮和吡啶[2,3- d：6,5- d ]二嘧啶-2,4,6,8-四元衍生物

  摘要：

  已经描述了在微波辅助条件下合成嘧啶并[4，5 - d ]嘧啶-2，4，7-三酮衍生物的有效和直接的方法。6-氨基-1,3-二甲基尿嘧啶与芳族醛的反应导致吡啶并[2,3- d：6,5 - d ]二嘧啶-2,4,6,8-四氢呋喃衍生物的形成。

  DOI：

  10.1016/j.tet.2006.12.043

文献信息

• An operationally simple green procedure for the synthesis of dihydropyrimido[4,5-<i>d</i>]pyrimidinetriones using CuI nanoparticles as a highly efficient catalyst
  作者：Shahrzad Abdolmohammadi、Maryam Afsharpour

  DOI：10.1515/znb-2014-0207

  日期：2015.3.1

  A green, efficient and simple protocol was developed for the synthesis of dihydropyrimido[4,5-d]pyrimidinetrione derivatives via a coupling reaction of 6-aminouracils, aromatic aldehydes and urea in aqueous media in the presence of nano-crystalline CuI at room temperature. The products were obtained in high yields. CuI nanoparticles can be recycled three times without significant loss of catalytic activity.

  摘要 本文开发了一种绿色、高效和简单的合成二氢嘧啶[4,5-d]嘧啶三酮衍生物的方法，通过在室温下在水介质中存在纳米晶CuI的情况下，6-氨基尿嘧啶、芳香醛和尿素的偶联反应合成。产物收率高。CuI纳米颗粒可循环使用三次，催化活性损失不显著。
• Sontakke, Madhuri M.; Dhonde, Madhukar G.; Bhaskar, Chandrakant S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 5, p. 629 - 636
  作者：Sontakke, Madhuri M.、Dhonde, Madhukar G.、Bhaskar, Chandrakant S.、Berad, Baliram N.

  DOI：——

  日期：——
• A novel and efficient synthesis of pyrimido[4,5-d]pyrimidine-2,4,7-trione and pyrido[2,3-d:6,5-d] dipyrimidine-2,4,6,8-tetrone derivatives
  作者：Minoo Dabiri、Hamid Arvin-Nezhad、Hamid Reza Khavasi、Ayoob Bazgir

  DOI：10.1016/j.tet.2006.12.043

  日期：2007.2

  An efficient and direct procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4,7-trione derivatives has been described under microwave-assisted conditions. Reaction of 6-amino-1,3-dimethyluracil with aromatic aldehydes resulted in the formation of pyrido[2,3-d:6,5-d] dipyrimidine-2,4,6,8-tetrone derivatives.

  已经描述了在微波辅助条件下合成嘧啶并[4，5 - d ]嘧啶-2，4，7-三酮衍生物的有效和直接的方法。6-氨基-1,3-二甲基尿嘧啶与芳族醛的反应导致吡啶并[2,3- d：6,5 - d ]二嘧啶-2,4,6,8-四氢呋喃衍生物的形成。