1,2,4,4,9-pentachloro-1,4-dihydro-2H-phenanthren-3-one | 100540-53-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,2,4,4,9-pentachloro-1,4-dihydro-2H-phenanthren-3-one
• 英文别名: 1,2,4,4,9-pentachloro-1,4-dihydro-2H-phenanthren-3-one；1,2,4,4,9-Pentachlor-1,4-dihydro-2H-phenanthren-3-on
• CAS: 100540-53-2
• 化学式: C₁₄H₇Cl₅O
• 分子量: 368.474
• InChiKey: VDCCBZPQIHDAOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.59
• 重原子数：
  20.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1,2,4,4,9-pentachloro-1,4-dihydro-2H-phenanthren-3-one 在 盐酸 、 tin 、 palladium on activated charcoal 、 硫酸 、 硝酸 、 sodium acetate 、 乙酸酐 、 溶剂黄146 、 tin(ll) chloride 作用下， 生成 1,3,4-triacetoxy-9,10-dihydro-phenanthrene
  参考文献：
  名称：

  Prevalence and severity of substance misuse among referrals to a local forensic service

  摘要：

  Substance misuse is frequently present alongside mental illness and personality disorder, complicating all aspects of management. We describe self-reported levels of substance misuse in referrals to a forensic psychiatry service, to establish degrees of dependency and co-morbidity with other diagnostic categories and to report the implications for treatment. There were 146 (70%) of 209 consecutive referrals who completed a semi-structured questionnaire, including the Alcohol Use Disorders Identification Test (AUDIT), Severity of Alcohol Dependency Questionnaire (SADQ), Alcohol Problem Questionnaire (APQ) and, for frequent users of opiates or stimulants, the Severity of Dependence Scales (SDS). Psychiatric diagnoses were made from clinical assessment using the International Classification of Diseases (World Health Organization, 1992). ICD-10 diagnoses of substance misuse were found in 83 (57%) subjects. A combination of mental illness and a substance misuse diagnosis was found in 54 (37%). The subgroup accepted into forensic psychiatric services was found to have higher levels of co-morbidity, although levels of dependency were low. Forensic services need expertise in assessing drug-related morbidity; in motivational interviewing and other techniques for encouraging change; and in consolidating recovery.

  DOI：

  10.1080/09585180110057154
• 作为产物：
  描述：

  3-菲醇 在 氯 、 溶剂黄146 作用下， 生成 1,2,4,4,9-pentachloro-1,4-dihydro-2H-phenanthren-3-one
  参考文献：
  名称：

  Mentally disordered parricide and stranger killers admitted to high-security care. 1: A descriptive comparison

  摘要：

  Parricide is an uncommon crime, so that many of the descriptive studies suffer from methodological shortcomings of small sample sizes and a non-representative ascertainment. We describe a consecutive series of mentally disordered offenders convicted of parricide who were admitted to high-security care and we compare their index characteristics with a group convicted of killing one or more strangers. The main findings were that the parricides were more likely to suffer from schizophrenia but less likely to have had a disrupted childhood and criminal history, as compared with those who had killed a stranger. Those in the parricide group had made a previous attack on their victim in 40% of cases. Overall, the study confirmed some of the differences that one might expect between these two groups of homicides, which had entirely different relationships to their victims.

  DOI：

  10.1080/09585180122057