8-chloroindolo[2,1-b]quinazoline-6,12-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-chloroindolo[2,1-b]quinazoline-6,12-dione
• 英文别名: 8-chlorotryptanthrin
• 化学式: C₁₅H₇ClN₂O₂
• 分子量: 282.686
• InChiKey: WUCIHZUJKXUKMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-chloroindolo[2,1-b]quinazoline-6,12-dione 在 一水合肼 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以69%的产率得到8-chloro-6-hydrazonoindolo[2,1-b]quinazolin-12(6H)-one
  参考文献：
  名称：

  Design, synthesis and biological evaluation of 8-substituted-6-hydrazonoindolo[2,1- b ]quinazolin-12(6 H )-one scaffolds as potential cytotoxic agents: IDO-1 targeting molecular docking studies

  摘要：

  Herein, we have reported the synthesis of 18 novel 8-substituted tryptanthrin analogues based on our earlier work. All these tryptanthrin analogues were well characterized by H-1 & C-13 NMR, FT-IR, Mass Spectrometry and Elemental Analysis. All these 8-substituted analogues were screened for their anti-oxidant activity by DPPH radical scavenging assay. Out of all the tested compounds, T-11, T-12,T-17 and T-18 showed potent anti-oxidant activity. The anti-cancer activity have been performed by using MTT assay protocol and their results depicts that compounds having the 4-pyridyl or 4-carboxyphenyl substituents at the 8th position of the tryptanthrin framework are found to be the most promising cytotoxic agent against A549, MCF-7 and HeLa human cancer cell lines compared to others as well as with the standard drug cisplatin. Moreover, the comparative molecular docking studies against the three protein receptors IDO1, EGFR and HER2 strongly suggested that IDO1 is the best target protein, which exhibits lowest binding energies of -11.73 and -11.61 kcal mol(-1) for T-11 and T-12 scaffolds, respectively towards the in vitro anti-cancer activity. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2017.08.064
• 作为产物：
  描述：

  N-(4-氯苯基)-2-(羟基亚胺)乙酰胺 在 硫酸 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.33h， 生成 8-chloroindolo[2,1-b]quinazoline-6,12-dione
  参考文献：
  名称：

  抗肿瘤剂色氨酸的合成与评价

  摘要：

  在这里，通过色氨酸和仲胺在温和的反应条件下反应快速制备 N-取代的色氨酸类似物，开发了一种有效和方便的方法。通过MTT测定法测试所有化合物在癌细胞系中的抗肿瘤活性。结果表明，其中一些对人肿瘤细胞系 A549、HCT116、MDA-MB-231 表现出抗肿瘤活性，IC 50平均值处于低微摩尔水平。具体而言，化合物3b剂量依赖性地诱导A549细胞中的G2/S细胞周期停滞和细胞凋亡。

  DOI：

  10.1016/j.tet.2021.132454

文献信息

• Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods
  申请人：PathoGenesis Corporation

  公开号：US05441955A1

  公开（公告）日：1995-08-15

  Methods, compounds and compositions are provided form inhibiting the growth of pathogenic mycobacteria in vitro and of treatment of pathogenic mycobacterial infections in vivo using indolo[2,1-b]quinazoline-6,12-dione compounds of the formula (I): ##STR1## wherein A, B, C, D, E, F, G and H are independently selected from carbon and nitrogen, or A and B or C and D can be taken together to be nitrogen or sulfur, and the pharmaceutically acceptable salts thereof. The methods, compounds and compositons are particularly useful for inhibiting the growth of Mycobacterium tuberculosis, and may be used alone, or in combination with other anti-Mycobacterium tuberculosis agents, such as isoniazid, rifampin, pyrazinamide, rifabutin, streptomycin and ciprofloxacin, to provide new agents for the treatment of tuberculosis, including multidrug-resistant tuberculosis (MDRTB).

  提供了一种用于体外抑制病原性分枝杆菌生长和用于体内治疗病原性分枝杆菌感染的方法、化合物和组合物，使用式(I)的吲哚并[2,1-b]喹唑啉-6,12-二酮化合物：##STR1## 其中A、B、C、D、E、F、G和H独立地选自碳和氮，或A和B或C和D可以结合在一起成为氮或硫，并且其药学上可接受的盐。这些方法、化合物和组合物特别适用于抑制结核分枝杆菌的生长，并可单独使用，或与其他抗结核分枝杆菌药物（如异烟肼、利福平、吡嗪酰胺、利福布汀、链霉素和环丙沙星）结合使用，以提供用于治疗结核病的新药物，包括多药耐药结核病（MDRTB）。
• Concise Synthesis of Tryptanthrin Spiro Analogues with In Vitro Antitumor Activity Based on One-Pot, Three-Component 1,3-Dipolar Cycloaddition of Azomethine Ylides to Сyclopropenes
  作者：Vitali Boitsov、Alexander Stepakov、Alexander Filatov、Nickolay Knyazev、Stanislav Shmakov、Alexey Bogdanov、Mikhail Ryazantsev、Andrey Shtyrov、Galina Starova、Alexander Molchanov、Anna Larina

  DOI：10.1055/s-0037-1611059

  日期：2019.2

  one-pot, three-component 1,3-dipolar cycloaddition reactions allow the desired products to be obtained from various cyclopropene derivatives with tryptanthrin-derived azomethine ylides generated in situ, in good to high yields and excellent diastereoselectivity. The possibility of ylide generation was exemplified by using α-amino acids (l-proline, l-4-thiazolidincarboxylic acid) and simplest peptides

  献给拉斐尔·科斯蒂科夫（Rafael Kostikov）教授。老师和朋友。 抽象的 已开发出一种简单，高效且原子经济的方法，用于合成螺环稠合的吲哚并[2,1- b ]喹唑啉和环丙基[ a ]吡咯嗪或3-氮杂双环[3.1.0]己烷的复杂生物碱样化合物。部分。我们已经发现，一锅，三组分的1，3-偶极环加成反应允许从各种环丙烯衍生物与就地产生的色胺酮衍生的偶氮甲亚胺，以良好至高收率和优异的非对映选择性从所需的环丙烯衍生物获得。产生叶立德的可能性通过使用α-氨基酸（l-脯氨酸，l-4-噻唑烷羧酸）和最简单的肽（二肽Gly-Gly，三肽Gly-Gly-Gly）。量子化学研究表明，该反应通过S形的甲亚胺叶立德进行，其与环丙烯的相互作用是通过较少受空间阻碍的内过渡态进行的。通过MTS分析在体外评估了一些螺旋-胰蛋黄素衍生物对红白血病（K562），宫颈癌（HeLa）和结肠癌（CT26）细胞系的抗肿瘤活性。
• A synthesis of spiroindolo[2,1-<i>b</i>]quinazoline-6,2'-pyrido[2,1-<i>b</i>][1,3]oxazines from tryptanthrins and Huisgen zwitterions
  作者：Issa Yavari、Mohammad Askarian-Amiri

  DOI：10.1080/00397911.2021.1899237

  日期：——

  Abstract The Huisgen zwitterionic intermediates, generated in situ from N-heterocycles and acetylenic esters were intercepted by tryptanthrins to afford novel spiroindolo[2,1-b]quinazoline-6,2'-pyrido[2,1-b][1,3]oxazines in CH2Cl2 at room temperature. Clear evidence for the structure of a derivative was obtained from single-crystal X-ray analyses. The most important feature of this reaction is the

  摘要 由N-杂环和炔属酯原位产生的Huisgen两性离子中间体被色胺酮拦截，从而得到新型螺吲哚并[2,1- b ]喹唑啉-6,2'-吡啶[2,1- b ] [1,3]室温下在CH 2 Cl 2中的恶嗪。从单晶X射线分析获得了明确的衍生物结构证据。该反应的最重要特征是它形成两个立体异构中心，其中一个是季铵盐，具有非对映选择性。
• Direct Catalytic Asymmetric Synthesis of β-Hydroxy Acids from Malonic Acid
  作者：Hang Gao、Zhenli Luo、Pingjin Ge、Junqian He、Feng Zhou、Peipei Zheng、Jun Jiang

  DOI：10.1021/acs.orglett.5b02891

  日期：2015.12.18

  A nickel(II) catalyzed asymmetric synthesis of β-hydroxy acids from malonic acid and ketones was developed, revealing for the first time the synthetic utility of malonic acid in the construction of chiral carboxyl acids; importantly, the synthetic potential of this strategy was further demonstrated by the rapid construction of cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.

  开发了镍（II）催化由丙二酸和酮不对称合成β-羟基酸的方法，这首次揭示了丙二酸在手性羧酸的合成中的合成作用。重要的是，该方法的合成潜力通过快速构建头孢菌素A，紫杉醇B，十字花青素和大米代谢产物得到了进一步证明。
• Ni(II)-Catalyzed Enantioselective Synthesis of β-Hydroxy Esters with Carboxylate Assistance
  作者：Na Wang、Hongxin Liu、Hang Gao、Jiafeng Zhou、Longzhangdi Zheng、Juan Li、Hong-Ping Xiao、Xinhua Li、Jun Jiang

  DOI：10.1021/acs.orglett.9b02297

  日期：2019.9.6

  decarboxylative aldol reaction between malonic acid half-oxyesters and various carbonyls with carboxylate assistance was developed, affording structurally diverse β-hydroxy esters with good yields and enantioselectivities under mild conditions. Importantly, the broad substrate scope of this methodology enabled rapid accesses to several natural products and their analogues as exemplified by phenylpropanoid, phaitanthrin

  建立了Ni-恶唑啉配合物催化丙二酸半含氧酸酯和各种羰基在羧酸酯辅助下的不对称脱羧醛醇缩合反应，在温和条件下以良好的收率和对映选择性提供了结构多样的β-羟基酯。重要的是，这种方法的广泛的底物范围使人们能够快速获得几种天然产物及其类似物，例如苯丙烷，类赤霉素B和邻苯二甲酸酯。