5-(2-Amino-1-hydroxypropyl)-2-iodophenol | 124201-36-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-Amino-1-hydroxypropyl)-2-iodophenol
• CAS: 124201-36-1
• 化学式: C₉H₁₂INO₂
• 分子量: 293.104
• InChiKey: KLNYAAKKPOJQNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(2-Amino-1-hydroxypropyl)-2-iodophenol 生成 4-<3H>metaraminol
  参考文献：
  名称：

  WIELAND, DONALD M.;ROSENSPIRE, KAREN C.;HUTCHINS, GARY D.;VAN, DORT MARCI+, J. MED. CHEM., 33,(1990) N, C. 956-964

  摘要：

  DOI：
• 作为产物：
  描述：

  metaraminol hydrogen (+)-tartrate 在 ammonium hydroxide 、 碘 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 5-(2-Amino-1-hydroxypropyl)-2-iodophenol
  参考文献：
  名称：

  Neuronal mapping of the heart with 6-[18F]fluorometaraminol

  摘要：

  The false neurotransmitter metaraminol labeled with fluorine-18 has been used to noninvasively assess regional adrenergic nerve density in the canine heart. Intravenous administration of 6-[18F]fluorometaraminol (FMR) results in high, selective accumulation of radioactivity in the heart; drug blocking studies with desipramine and reserpine confirm the neuronal locus of FMR. Iodine-125 labeled metaraminol, however, shows no selective accumulation in the canine heart. Positron emission tomography (PET) analyses with FMR of closed-chest dogs bearing left ventricular neuronal defects clearly delineate the region of neuronal impairment; blood perfusion in the left ventricle wall was homogeneous as determined by [13N]NH3 tomograms. The accumulation of FMR in regionally denervated dog heart correlates closely (r = 0.88) with endogenous norepinephrine concentrations. PET-generated 18F time-activity curves demonstrate marked kinetic differences between normal and denervated myocardium. FMR/PET analysis could be used to assess the heterogeneity of sympathetic innervation in human heart disease contingent on the development of FMR with sufficiently high specific activity to clearly avoid pressor activity.

  DOI：

  10.1021/jm00165a012

文献信息

• WIELAND, DONALD M.;ROSENSPIRE, KAREN C.;HUTCHINS, GARY D.;VAN, DORT MARCI+, J. MED. CHEM., 33,(1990) N, C. 956-964
  作者：WIELAND, DONALD M.、ROSENSPIRE, KAREN C.、HUTCHINS, GARY D.、VAN, DORT MARCI+

  DOI：——

  日期：——
• Neuronal mapping of the heart with 6-[18F]fluorometaraminol
  作者：Donald M. Wieland、Karen C. Rosenspire、Gary D. Hutchins、Marcian Van Dort、Jill M. Rothley、Suresh G. Mislankar、Helen T. Lee、Christopher C. Massin、David L. Gildersleeve

  DOI：10.1021/jm00165a012

  日期：1990.3

  The false neurotransmitter metaraminol labeled with fluorine-18 has been used to noninvasively assess regional adrenergic nerve density in the canine heart. Intravenous administration of 6-[18F]fluorometaraminol (FMR) results in high, selective accumulation of radioactivity in the heart; drug blocking studies with desipramine and reserpine confirm the neuronal locus of FMR. Iodine-125 labeled metaraminol, however, shows no selective accumulation in the canine heart. Positron emission tomography (PET) analyses with FMR of closed-chest dogs bearing left ventricular neuronal defects clearly delineate the region of neuronal impairment; blood perfusion in the left ventricle wall was homogeneous as determined by [13N]NH3 tomograms. The accumulation of FMR in regionally denervated dog heart correlates closely (r = 0.88) with endogenous norepinephrine concentrations. PET-generated 18F time-activity curves demonstrate marked kinetic differences between normal and denervated myocardium. FMR/PET analysis could be used to assess the heterogeneity of sympathetic innervation in human heart disease contingent on the development of FMR with sufficiently high specific activity to clearly avoid pressor activity.