4-acetoxyphenyl-N-(4-methoxyphenyl)imine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-acetoxyphenyl-N-(4-methoxyphenyl)imine
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: HIWTZFIUDYPPFO-GZTJUZNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  47.89
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-acetoxyphenyl-N-(4-methoxyphenyl)imine 在 甲醇 、 氢氧化钾 、 三乙胺 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 3.08h， 生成 3-羟基-4-(4-羟基苯基)-1-(4-甲氧基苯基)氮杂环丁烷-2-酮
  参考文献：
  名称：

  Antibiotic-conjugated polyacrylate nanoparticles: New opportunities for development of anti-MRSA agents

  摘要：

  This report describes the preparation of polyacrylate nanoparticles in which an N-thiolated beta-lactam antibiotic is covalently conjugated onto the polymer framework. These nanoparticles are formed in water by emulsion polymerization of an acrylated antibiotic pre-dissolved in a liquid acrylate monomer (or mixture of co-monomers) in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 40 nm in diameter. The emulsions have potent in vitro antibacterial properties against methicillin-resistant Staphylococcus aureus and have improved bioactivity relative to the non-polymerized form of the antibiotic. A unique feature of this methodology is the ability to incorporate water-insoluble drugs directly into the nanoparticle framework without the need for post-synthetic modification. Additionally, the antibiotic properties of the nanoparticles can be modulated by changing the length or location of the acrylate linker on the drug monomer. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.098
• 作为产物：
  描述：

  甲氧苯胺 在 (+)-10-camphorsulfonic acid 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 生成 4-acetoxyphenyl-N-(4-methoxyphenyl)imine
  参考文献：
  名称：

  Antibiotic-conjugated polyacrylate nanoparticles: New opportunities for development of anti-MRSA agents

  摘要：

  This report describes the preparation of polyacrylate nanoparticles in which an N-thiolated beta-lactam antibiotic is covalently conjugated onto the polymer framework. These nanoparticles are formed in water by emulsion polymerization of an acrylated antibiotic pre-dissolved in a liquid acrylate monomer (or mixture of co-monomers) in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 40 nm in diameter. The emulsions have potent in vitro antibacterial properties against methicillin-resistant Staphylococcus aureus and have improved bioactivity relative to the non-polymerized form of the antibiotic. A unique feature of this methodology is the ability to incorporate water-insoluble drugs directly into the nanoparticle framework without the need for post-synthetic modification. Additionally, the antibiotic properties of the nanoparticles can be modulated by changing the length or location of the acrylate linker on the drug monomer. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.098

文献信息

• COMPOSITION AND METHOD FOR TEMPORARILY FIXING SOLID
  申请人：JSR Corporation

  公开号：EP1522567A1

  公开（公告）日：2005-04-13

  The present invention relates to a method of temporarily and firmly fixing two solids to each other and to a composition used in the method, which is a method of temporarily fixing, comprising temporarily fixing the two solids to each other with a liquid crystal compound or a composition comprising the liquid crystal compound. This method is used for a method of temporarily fixing a pad for chemical mechanical polishing, for example, to polish a wafer for a semiconductor device fixed on a surface of a base plate, when one solid is a pad for chemical mechanical polishing of a wafer for a semiconductor device and the other is a base plate to fix the pad.

  本发明涉及一种将两个固体暂时牢固地相互固定的方法以及用于该方法的组合物，该方法是一种暂时固定的方法，包括用液晶化合物或包含液晶化合物的组合物将两个固体暂时相互固定。该方法用于临时固定化学机械抛光垫的方法，例如，用于抛光固定在底板表面上的半导体器件晶片，其中一个固体是用于半导体器件晶片化学机械抛光的垫，另一个固体是用于固定垫的底板。
• Composition and method for temporarily fixing solid
  申请人：——

  公开号：US20040185187A1

  公开（公告）日：2004-09-23

  The present invention relates to a method of temporarily and firmly fixing two solids to each other and to a composition used in the method, which is a method of temporarily fixing, comprising temporarily fixing the two solids to each other with a liquid crystal compound or a composition comprising the liquid crystal compound. This method is used for a method of temporarily fixing a pad for chemical mechanical polishing, for example, to polish a wafer for a semiconductor device fixed on a surface of a base plate, when one solid is a pad for chemical mechanical polishing of a wafer for a semiconductor device and the other is a base plate to fix the pad.

  本发明涉及一种将两个固体暂时牢固地相互固定的方法以及用于该方法的组合物，该方法是一种暂时固定的方法，包括用液晶化合物或包含液晶化合物的组合物将两个固体暂时相互固定。该方法用于临时固定化学机械抛光垫的方法，例如，用于抛光固定在底板表面上的半导体器件晶片，其中一个固体是用于半导体器件晶片化学机械抛光的垫，另一个固体是用于固定垫的底板。
• [EN] NANOPARTICLES FOR DRUG-DELIVERY<br/>[FR] NANOPARTICULES POUR APPORT DE MEDICAMENT
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2005020933A3

  公开（公告）日：2005-06-09
• Thermoplastic resin compositions for the preparation of foams
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0049333B1

  公开（公告）日：1984-06-13
• US4343911A
  申请人：——

  公开号：US4343911A

  公开（公告）日：1982-08-10