tetrachloro(2,2'-bipyridine)platinum(IV) | 16949-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tetrachloro(2,2'-bipyridine)platinum(IV)
• 英文别名: [PtCl4(2,2'-bipyridyl)]；(2,2'-bipyridyl)PtCl4；[PtCl₄(2,2'-bipyridine)]；PtCl4(2,2′-bipyridyl)；[PtCl₄(bipy)]；[Pt(bpy)Cl4]
• CAS: 16949-85-2
• 化学式: C₁₀H₈Cl₄N₂Pt
• 分子量: 493.079
• InChiKey: ZYEZKBAVRHQRSG-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  tetrachloro(2,2'-bipyridine)platinum(IV) 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2,2-联吡啶)二氯铂(II)
  参考文献：
  名称：

  Aquapentachloro-和六氯铂酸的配体取代反应-四氯铂 (IV) 与杂环 N、N 供体配合物的合成和表征

  摘要：

  水合五氯铂酸 (H3O) [PtCl5 (H2O)] · 2 (18C6) · 6H2O (1) (18C6 = 18-crown-6) 和 H2 [PtCl6] · 6H2O (2) 与杂环 N、N 供体的反应(2, 2'-bipyridine, bpy; 4, 4'-di-tert-butyl-2, 2'-bipyridine, tBu2bpy; 1, 10-phenanthroline, phen; 4, 7-diphenyl-1, 10-phenanthroline, Ph2phen; 2, 2'-bipyrimidine, bpym) 配体取代铂 (IV) 配合物 [PtCl4 (N∩N)] (N∩N = bpy, 3a; tBu2bpy, 3b; Ph2phen, 5; bpym, 7) 和/ 或 N 质子化，N 供体产生 (R2phenH) 2 [PtCl6] (R = H,

  DOI：

  10.1002/zaac.200390119
• 作为产物：
  描述：

  (2,2-联吡啶)二氯铂(II) 在 氯仿 作用下， 生成 tetrachloro(2,2'-bipyridine)platinum(IV)
  参考文献：
  名称：

  Vogler, Arnd; Kunkely, Horst, Angewandte Chemie, 1982, vol. 94, # 3, p. 217

  摘要：

  DOI：

文献信息

• Ionic Liquid in Synthesis: A Phase Transfer Reagent and a Redox Mediating Medium
  作者：Guei-Wei Lin、Yi-Chin Lin、Su-Ching Lin、Yuh-Sheng Wen、Ling-Kang Liu

  DOI：10.1002/jccs.201200408

  日期：2013.3

  Ionic liquids (ILs) with chloride anion or bromide anion were attempted as a phase transfer reagent to depolymerize MX2 (M = Pt, Pd; X = Br, Cl) in chloroform for reaction with 2,2′‐bipyridine (= bpy) to give the (bpy)MX2 product. Supersonic irradiation of equiv‐molar bpy, PdX2, and IL in CHCl3 produced almost quantitative precipitate of (bpy)PdX2 in a short time at ambient temperature, where IL is

  尝试使用具有氯离子或溴离子的离子液体（ILs）作为相转移试剂来解聚MX 2（M = Pt，Pd; X = Br，Cl）在氯仿中与2,2'-联吡啶（= bpy）反应提供（bpy）MX 2产品。在环境温度下，短时间内在CHCl 3中对等摩尔bpy，PdX 2和IL进行超音速照射几乎产生了（bpy）PdX 2的几乎定量沉淀，其中IL为[BEIm] Br或[BMIm] Br。也就是说，离子液体和声波技术对（bpy）PdX 2的合成有很大帮助。用于制备（bpy）PtX 2但是，即使经过长时间的超声处理，游离的bpy仍始终保留在混合物中。在CHCl 3中的等摩尔bpy，PtBr 2和IL体系生成黄色（bpy）PtBr 2和橙色（bpy）PtBr 4，在d 6- Me 2 SO中均具有1 H NMR和195 Pt NMR表征。以及单晶X射线衍射。在归因于ILs的高极性环境中，对于PtX 2与卤化物阴离子
• Reduction of some Pt(iv) complexes with biologically important sulfur-donor ligands
  作者：Snežana Jovanović、Biljana Petrović、Živadin D. Bugarčić、Rudi van Eldik

  DOI：10.1039/c3dt50751c

  日期：——

  The reduction of the Pt(IV) complexes [PtCl4(bipy)], [PtCl4(dach)] and [PtCl4(en)] by glutathione (GSH), L-cysteine (L-Cys) and L-methionine (L-Met) was investigated by stopped-flow spectrophotometry at pH 2.0 (in 0.01 M perchloric acid) and at pH 7.2 (in 25 mM Hepes buffer). Kinetic measurements were performed under pseudo-first order conditions with an excess of the reducing agent. The order of the reactivity of the studied complexes was [PtCl4(bipy)] > [PtCl4(dach)] > [PtCl4(en)], and reactivity of investigated reducing agents followed the order GSH > L-Cys > L-Met. All the reactions between the selected Pt(IV) complexes and the sulfur donor biomolecules proceeded by a reductive elimination process that included nucleophilic attack by the reducing agent on one of the mutually trans-coordinated chloride ligands, which led to a two-electron transfer process. The final products of the redox reactions were the corresponding reduced Pt(II) complexes and the oxidized form of the reducing agents.

  在 pH 值为 2.0（在 0.01 M 高氯酸中）和 pH 值为 7.2（在 25 mM Hepes 缓冲液中）的条件下，通过停流分光光度法研究了谷胱甘肽（GSH）、L-半胱氨酸（L-Cys）和 L-蛋氨酸（L-Met）对铂(IV)复合物[PtCl4(bipy)]、[PtCl4(dach)]和[PtCl4(en)]的还原作用。动力学测量是在还原剂过量的假一阶条件下进行的。所研究复合物的反应性顺序为[PtCl4(bipy)] > [PtCl4(dach)] > [PtCl4(en)]，所研究还原剂的反应性顺序为 GSH > L-Cys > L-Met。所选铂(IV)配合物与硫供体生物大分子之间的所有反应都是通过还原消除过程进行的，其中包括还原剂对相互反式配位的氯配体之一的亲核攻击，从而导致双电子转移过程。氧化还原反应的最终产物是相应的还原铂（II）络合物和还原剂的氧化形式。
• Redox reactions of platinum-(<scp>II</scp>) and -(<scp>IV</scp>) complexes: influence of the σ-donor ability of non-labile 2,2′-bipyridyl and substituted 1,10-phenanthroline ligands on the rates of reaction
  作者：Arnaldo Peloso

  DOI：10.1039/dt9760000984

  日期：——

  fast redox step. An inner-sphere redox mechanism is thought to be responsible for the second-order rate term. The dissociative path is only slightly affected by changes in N–N, whereas the second-order term is strongly influenced by the σ-donor ability of the uncharged ligands, the relation log k2=–0.62 PKa+ 2.05 being found at 25 °C. The rate law for the oxidation of [PtCl2,(N–N)] by [AuCl4]– has the

  [NBu 4 ] I还原[PtCl 4（N–N）]和[AuCl 4 ]氧化[PtCl 2（N–N）] –在存在氯离子的情况下，已在乙腈中进行了动力学研究[ N–N = 1,10-菲咯啉（phen），5Me-，5NO 2-，5,6Me 2-和3,4,7,8Me 4 -phen或2,2'-联吡啶（bipy）]。[PtCl 4（N–N）]还原的速率定律具有以下形式：稀有= k 1 [PtCl 4（N–N）] + k 2 [PtCl 4（N–N）] [I –]。一级速率术语归因于解离性Pt-Cl速率决定键的断裂，然后是快速的氧化还原步骤。内层氧化还原机制被认为是造成二阶速率项的原因。离解路径仅受N–N变化的轻微影响，而二阶项受不带电荷配体的σ供体能力的强烈影响，在以下位置可找到关系log k 2 = –0.62 P K a + 2.05 25℃。为[氯铂酸的氧化的速率定律2，（N-N）]由[AUCL
• Cytotoxic properties of platinum(IV) and dinuclear platinum(II) complexes and their ligand substitution reactions with guanosine-5′-monophosphate
  作者：Miloš Arsenijević、Marija Milovanović、Vladislav Volarević、Dragan Čanović、Nebojša Arsenijević、Tanja Soldatović、Snežana Jovanović、Živadin D. Bugarčić

  DOI：10.1007/s11243-012-9613-4

  日期：2012.8

  The substitution reaction of the Pt(IV) complex [PtCl4(bipy)] with guanosine-5′-monophosphate (5′-GMP) was studied by UV–Vis spectrophotometry. This reaction was investigated under pseudo-first-order conditions at 37 °C in 25 mM Hepes buffer (pH = 7.2) in the presence of 10 mM NaCl to prevent the hydrolysis of the complex. The substitution of chlorides in [trans-Pt(NH3)2Cl}2(μ-1,2-bis(4-pyridyl)ethane)](ClO4)2

  通过紫外-可见分光光度法研究了 Pt(IV) 络合物 [PtCl4(bipy)] 与 5'-单磷酸鸟苷 (5'-GMP) 的取代反应。在 37 °C 下，在 25 mM Hepes 缓冲液（pH = 7.2）中，在 10 mM NaCl 存在下，在伪一级条件下研究该反应，以防止复合物水解。[trans-Pt(NH3)2Cl}2(μ-1,2-bis(4-pyridyl)ethane)](ClO4)2 (Pt3) 复合物中的氯化物被 5'-GMP 取代，然后进行 1H NMR二阶条件下的光谱。获得了两个取代步骤的速率常数非常相似的值。Pt(IV) 配合物 [PtCl4(bipy)] 和 [PtCl4(dach)]，以及双核 Pt(II) [trans-Pt(NH3)2Cl}2(μ-pyrazine)]( )2 (Pt1), [trans-Pt(NH3)2Cl}2(μ-4,4'-bipyridyl)]( )2
• Fedotova; Kravchenko; Sakharov, Russian Journal of Inorganic Chemistry, 2005, vol. 50, # 4, p. 527 - 533
  作者：Fedotova、Kravchenko、Sakharov

  DOI：——

  日期：——