2-(6-methoxymethoxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo[1,2-b]pyran-2-yl)ethanol | 132768-98-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(6-methoxymethoxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo[1,2-b]pyran-2-yl)ethanol
• 英文别名: 2-(6-methoxymethoxy-2,5,7,8-tetramethylchroman-2-yl)ethanol；2-[6-(Methoxymethoxy)-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl]ethanol
• CAS: 132768-98-0
• 化学式: C₁₇H₂₆O₄
• 分子量: 294.391
• InChiKey: DYSDECZRMCQJRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(6-methoxymethoxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo[1,2-b]pyran-2-yl)ethanol 在 palladium on activated charcoal 吡啶 、 copper(I) oxide 、 盐酸 、 硫酸 、 氢气 、 sodium hydride 、 溶剂黄146 、 sodium nitrite 作用下， 以 甲醇 、 苯 为溶剂， 生成 5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione
  参考文献：
  名称：

  Studies on hindered phenols and analogs. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation

  摘要：

  A series of hindered phenols were investigated as hypolipidemic and/or hypoglycemic agents with ability to inhibit lipid peroxidation. 1,3-Benzoxathioles (9 and 22), phenoxypentanoic acid (34), phenoxypentanol (35a), phenoxynonanol (35b), phenylchloropropionic acid having a chromanyl group (25), and a thiazolidine compound (27) derived from 25, all having a hindered phenol group, were prepared and examined. Compound 27 showed the expected biological properties in vivo and in vitro without any liver weight increase. Biological activities of the analogous thiazolidine compounds, 43-58, were compared. Thus, (+/-)-5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]- benzyl]-2,4-thiazolidinedione (27) (CS-045) was found to have all of our expected properties and was selected as a candidate for further development as a hypoglycemic and hypolipidemic agent.

  DOI：

  10.1021/jm00122a022
• 作为产物：
  描述：

  3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ethanol 、 氯甲基甲基醚 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.75h， 生成 2-(6-methoxymethoxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo[1,2-b]pyran-2-yl)ethanol
  参考文献：
  名称：

  [EN] COMPOSITIONS CAPABLE OF INHIBITING REACTIVE OXYGEN AND CARBONYL SPECIES
  [FR] COMPOSITIONS CAPABLES D'INHIBER LES ESPECES A OXYGENE ET CARBONYLE REACTIFS

  摘要：

  提供了治疗性组合物。这些组合物包括一种单一分子，它既具有抗氧化性又具有羰基捕获性能。这可以有效减少炎症、氧化应激和羰基应激，从而预防和/或治疗肾脏疾病患者的心血管疾病和炎症性疾病。

  公开号：

  WO2006019855A1

文献信息

• Benzopyran derivatives
  申请人：Ono Pharmaceutical Co., Ltd.

  公开号：US05055598A1

  公开（公告）日：1991-10-08

  Benzopyran derivatives of the formula: ##STR1## wherein the variables are defined in the specification and the pharmaceutically acceptable acid addition salts thereof possess the inhibitory activity on Maillard reaction and an antioxidizing effect, and therefore, are useful for the prevention and treatment of several diabetic complications, diseases induced by aging and several diseases caused by formation of peroxidized fat.

  苯并吡喃衍生物的化学式为：##STR1## 其中变量在规范中有定义，以及其药用酸盐具有对美拉德反应的抑制活性和抗氧化作用，因此对于预防和治疗多种糖尿病并发症、老化引起的疾病以及因过氧化脂肪形成引起的多种疾病是有用的。
• Compositions capable of inhibiting reactive oxygen and carbonyl species
  申请人：Hai That Ton

  公开号：US20060016752A1

  公开（公告）日：2006-01-26

  Therapeutic compositions are provided. The compositions include a single molecule that can display both antioxidant and carbonyl trapping properties. This can effectively reduce inflammation, oxidative stress and carbonyl stress, such as to prevent and/or treat cardiovascular disease and inflammatory diseases in kidney disease patients.

  提供治疗组合物。该组合物包括一种单一分子，可以同时表现出抗氧化和羰基捕捉特性。这可以有效地减少炎症、氧化应激和羰基应激，从而预防和/或治疗肾病患者的心血管疾病和炎症性疾病。
• COMPOSITIONS CAPABLE OF INHIBITING REACTIVE OXYGEN AND CARBONYL SPECIES
  申请人：Baxter International Inc.

  公开号：EP1771168A1

  公开（公告）日：2007-04-11
• US5055598A
  申请人：——

  公开号：US5055598A

  公开（公告）日：1991-10-08
• US5169957A
  申请人：——

  公开号：US5169957A

  公开（公告）日：1992-12-08