(8S,9S,10R,11S,13S,14S,17S)-11,17-二羟基-10,13,17-三甲基-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-3-酮 | 1043-10-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: (8S,9S,10R,11S,13S,14S,17S)-11,17-二羟基-10,13,17-三甲基-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-3-酮
• 英文名称: 11β-hydroxy-17α-methyltestosterone
• 英文别名: 11β,17β-dihydroxy-17α-methyl-androst-4-en-3-one；11β,17β-Dihydroxy-17α-methyl-androst-4-en-3-on；(11β,17β)-11,17-dihydroxy-17-methyl-androst-4-en-3-one；11β,17β-dihydroxy-17-methylandrost-4-en-3-one；fluoxymesterone；11β-Hydroxy-17α-methyl-testosteron；Testosterone, 11beta-hydroxy-17-methyl-；(8S,9S,10R,11S,13S,14S,17S)-11,17-dihydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 1043-10-3
• 化学式: C₂₀H₃₀O₃
• 分子量: 318.456
• InChiKey: UBIBSXMTVJAYTQ-OWLVHUDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

SDS

Name:	11alpha-Hydroxy-17alpha-methyltestosterone Material Safety Data Sheet
Synonym:
CAS:	1043-10-3

Section 1 - Chemical Product MSDS Name:11alpha-Hydroxy-17alpha-methyltestosterone Material Safety Data Sheet
Synonym:

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1043-10-3	11alpha-hydroxy-17alpha-methyltestoste		213-871-9

Hazard Symbols: Not available.
Risk Phrases:

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
The toxicological properties of this material have not been investigated. Use appropriate procedures to prevent opportunities for direct contact with the skin or eyes and to prevent inhalation.

---

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire.
Autoignition Temperature: Not available.
Flash Point: Not available.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section.

---

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Hormones and antibiotics room.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Personal Protective Equipment Eyes: Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements must be followed whenever workplace conditions warrant a respirator's use.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Not available.
Appearance: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 153.00 - 155.00 deg C
Decomposition Temperature: Not available.
Solubility: Not available.
Specific Gravity/Density: Not available.
Molecular Formula: C20H30O3
Molecular Weight: 318.44

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Not available.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1043-10-3: BV8383000 LD50/LC50:
Not available.
Carcinogenicity:
11alpha-hydroxy-17alpha-methyltestosterone - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.

---

Section 12 - ECOLOGICAL INFORMATION
For further information, contact Fisher Scientific.

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

CDG/CPL
IMO
Not regulated as a hazardous material.
IATA
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
Canadian TDG
No information available.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1043-10-3:
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
WHMIS: Not available.
CAS# 1043-10-3 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 1043-10-3 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (8S,9S,10R,11S,13S,14S,17S)-11,17-二羟基-10,13,17-三甲基-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-3-酮 在 N-溴代乙酰胺 作用下， 生成 甲睾酮
  参考文献：
  名称：

  9alpha-halo-11-keto-17-alkyltestosterones

  摘要：

  公开号：

  US02793218A1
• 作为产物：
  描述：

  17-甲睾酮 生成 (8S,9S,10R,11S,13S,14S,17S)-11,17-二羟基-10,13,17-三甲基-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-3-酮
  参考文献：
  名称：

  11 beta-hydroxy-17-ethynyl testosterone and esters thereof

  摘要：

  公开号：

  US02740798A1

文献信息

• Androgen as a male contraceptive and non-contraceptive androgen replacement
  申请人：——

  公开号：US20040132698A1

  公开（公告）日：2004-07-08

  The present invention relates to methods of providing male contraception using a specified androgen without the need of a separate sterilizing agent. The invention also describes methods for non-contraceptive androgen replacement and devices useful for carrying out both processes.

  本发明涉及使用特定雄性激素提供男性避孕的方法，而不需要单独的绝育剂。本发明还描述了非避孕性雄激素替代方法和用于实施这两种过程的装置。
• Steroidal 3,5-dienes
  作者：Philip M. Weintraub、Paul L. Tiernan、Harvey D. Benson、Joyce F. Grunwell、J. O'Neal Johnston、V. Petrow

  DOI：10.1021/jm00234a009

  日期：1976.12
• Camerino,B. et al., Gazzetta Chimica Italiana, 1962, vol. 92, p. 693 - 708
  作者：Camerino,B. et al.

  DOI：——

  日期：——
• The Synthesis of Some 7α- and 7β-Methyl Steroid Hormones¹
  作者：J Allan Campbell、John C. Babcock

  DOI：10.1021/ja01524a063

  日期：1959.8
• SYNTHESIS OF POTENT ORAL ANABOLIC-ANDROGENIC STEROIDS
  作者：M. E. Herr、J. A. Hogg、R. H. Levin

  DOI：10.1021/ja01583a072

  日期：1956.1

表征谱图